Arnold E Hampel

US Patent:

20050042620, Feb 24, 2005

Filed:

Sep 15, 2003

Appl. No.:

10/664835

Inventors:

Arnold Hampel - DeKalb IL, US
Richard Tritz - DeKalb IL, US
Margaret Hicks - Antioch TN, US

International Classification:

C12Q001/68
C07H021/02
C12P019/34

US Classification:

435006000, 435091200, 536023100

Abstract:

A synthetic RNA catalyst capable of cleaving an RNA substrate, the catalyst comprising a substrate binding portion and a “hairpin” portion. The invention also provides an engineered DNA molecule and a vector, each comprising a DNA sequence coding for an RNA catalyst according to the invention. The invention further comprises host cells transformed with the vectors of the invention which are capable of expressing the RNA catalyst. Finally, the invention provides a method of cleaving an RNA substrate which comprises contacting the substrate with a synthetic RNA catalyst according to the invention.

US Patent:

56839022, Nov 4, 1997

Filed:

Mar 21, 1995

Appl. No.:

8/410005

Inventors:

Arnold Hampel - DeKalb IL
Joseph DiPaolo - Bethesda MD
Andrew M. Siwkowski - Sycamore IL
Scott C. Galasinski - Rockford IL

Assignee:

Northern Illinois University - DeKalb IL
United States of America as represented by the Department of Health and
Human Services - Washington DC

International Classification:

C12P 1934
C12N 1500
C12N 500
C07H 2102

US Classification:

4352402

Abstract:

Synthetic catalytic RNAs, i. e. ribozyme, including a hairpin portion, binding sites for binding to a human papilloma virus after viral base 419 and 434, respectively, and cleavage sites for cleaving the virus at the binding sites have been constructed.

US Patent:

55278957, Jun 18, 1996

Filed:

Nov 16, 1993

Appl. No.:

8/153367

Inventors:

Arnold E. Hampel - DeKalb IL
Richard H. Tritz - Lisle IL

Assignee:

The Board of Regents for Northern Illinois University of DeKalb - DeKalb IL

International Classification:

C12H 1554
C12H 1585
C12H 922
A61K 3170

US Classification:

536 232

Abstract:

A synthetic RNA catalyst capable of cleaving an RNA substrate, the catalyst omprising a substrate binding portion and a "hairpin" portion. The invention also provides an engineered DNA molecule and a vector, each comprising a DNA sequence coding for an RNA catalyst according to the invention. The invention further comprises host cells transformed with the vectors of the invention which are capable of expressing the RNA catalyst. Finally, the invention provides a method of cleaving an RNA substrate which comprises contacting the substrate with a synthetic RNA catalyst according to the invention.

US Patent:

58561889, Jan 5, 1999

Filed:

Jun 7, 1995

Appl. No.:

8/485689

Inventors:

Arnold E. Hampel - DeKalb IL
Richard H. Tritz - DeKalb IL
Margaret F. Hicks - Antioch TN

Assignee:

The Board of Regents for Northern Illinois University of DeKalb - DeKalb IL
Biotechnology Research and Development Corporation - Peoria IL

International Classification:

C12N 500
C12Q 168
C07H 2104

US Classification:

435375

Abstract:

A synthetic RNA catalyst capable of cleaving an RNA substrate, the catalyst comprising a substrate binding portion and a "hairpin" portion. The invention also provides an engineered DNA molecule and a vector, each comprising a DNA sequence coding for an RNA catalyst according to the invention. The invention further comprises host cells transformed with the vectors of the invention which are capable of expressing the RNA catalyst. Finally, the invention provides a method of cleaving an RNA substrate which comprises contacting the substrate with a synthetic RNA catalyst according to the invention.

US Patent:

56460317, Jul 8, 1997

Filed:

May 16, 1995

Appl. No.:

8/442513

Inventors:

Mary Beth DeYoung - Elmhurst IL
Andrew M. Siwkowski - Sycamore IL
Arnold E. Hampel - DeKalb IL

Assignee:

Northern Illinois University - DeKalb IL

International Classification:

C07H 2104
C12Q 168
A61K 4800
C12N 1585

US Classification:

435325

Abstract:

A method for the identification by modeling of synthetic catalytic RNAs and ribozymes thereof are disclosed including a hairpin portion and binding sites for cleaving an RNA substrate at a site which has a GUA sequence following the site of cleavage. Synthetic catalytic RNA has been modeled from negative strands of satellite RNA from the group consisting of chicory yellow mottle virus (sCYMVI) and arabis mosaic virus (sArMV).

US Patent:

58693394, Feb 9, 1999

Filed:

Jun 7, 1995

Appl. No.:

8/478608

Inventors:

Arnold E. Hampel - DeKalb IL
Richard H. Tritz - DeKalb IL
Margaret F. Hicks - Antioch TN

Assignee:

The Board of Regents for Northern Illinois University of DeKalb - DeKalb IL
Biotechnology Research and Development Corporation - Peoria IL

International Classification:

C12N 1500
C12Q 618
C07H 2104

US Classification:

435375

Abstract:

A synthetic RNA catalyst capable of cleaving an RNA substrate, the catalyst comprising a substrate binding portion and a "hairpin" portion. The invention also provides an engineered DNA molecule and a vector, each comprising a DNA sequence coding for an RNA catalyst according to the invention. The invention further comprises host cells transformed with the vectors of the invention which are capable of expressing the RNA catalyst. Finally, the invention provides a method of cleaving an RNA substrate which comprises contacting the substrate with a synthetic RNA catalyst according to the invention.

US Patent:

62216619, Apr 24, 2001

Filed:

Jun 7, 1995

Appl. No.:

8/476423

Inventors:

Arnold E. Hampel - DeKalb IL
Richard H. Tritz - DeKalb IL
Margaret F. Hicks - Antioch TN

Assignee:

The of Regents for Northern Illinois University of DeKalb - DeKalb IL
Biotechnology Research and Development Corporation - Peoria IL

International Classification:

C12N 1585
C12Q 168
C07H 2104

US Classification:

435366

Abstract:

A synthetic RNA catalyst capable of cleaving an RNA substrate, the catalyst comprising a substrate binding portion and a "hairpin" portion. The invention also provides an engineered DNA molecule and a vector, each comprising a DNA sequence coding for an RNA catalyst according to the invention. The invention further comprises host cells transformed with the vectors of the invention which are capable of expressing the RNA catalyst. Finally, the invention provides a method of cleaving an RNA substrate which comprises contacting the substrate with a synthetic RNA catalyst according to the invention.

US Patent:

58667016, Feb 2, 1999

Filed:

Jun 17, 1993

Appl. No.:

8/078774

Inventors:

Arnold E. Hampel - DeKalb IL
Richard H. Tritz - DeKalb IL

Assignee:

The Board of Regents for Northern Illinois University of DeKalb - DeKalb IL
Biotechnology Research and Development Corporation - Peoria IL

International Classification:

C12N 1554
C12N 1585
C12N 922
A61K 3170

US Classification:

536 232

Abstract:

A synthetic RNA catalyst capable of cleaving an RNA substrate, the catalyst comprising a substrate binding portion and a "hairpin" portion. The invention also provides an engineered DNA molecule and a vector, each comprising a DNA sequence coding for an RNA catalyst according to the invention. The invention further comprises host cells transformed with the vectors of the invention which are capable of expressing the RNA catalyst. Finally, the invention provides a method of cleaving an RNA substrate which comprises contacting the substrate with a synthetic RNA catalyst according to the invention.