Arvind Kumar

US Patent:

20030199521, Oct 23, 2003

Filed:

Jan 11, 2002

Appl. No.:

10/044315

Inventors:

Christine Dykstra - Auburn AL, US
Maurice Givens - Auburn AL, US
David Stringfellow - Auburn AL, US
Kenny Brock - Auburn AL, US
David Boykin - Atlanta GA, US
Arvind Kumar - Atlanta GA, US
W. Wilson - Atlanta GA, US
Richard Tidwell - Pittsboro NC, US
Chad Stephens - Villa Roca GA, US

International Classification:

C07D417/14
C07D413/14
C 07D 4 3/14
A61K031/506
A61K031/428
A61K031/427
A61K031/423
A61K031/422
A61K031/4184

US Classification:

514/256000, 514/367000, 514/365000, 514/394000, 514/397000, 544/333000, 548/217000, 548/181000, 548/215000, 548/152000, 548/306100, 514/374000

Abstract:

The present invention relates to novel compounds and methods that are useful in treating members of the Flaviviridae family of viruses. Compounds of the present invention will have a structure according to Formulas (I)-(VI) as recited throughout the application.

US Patent:

20060063931, Mar 23, 2006

Filed:

Oct 28, 2005

Appl. No.:

11/262427

Inventors:

Christine Dykstra - Auburn AL, US
Maurice Givens - Auburn AL, US
David Stringfellow - Auburn AL, US
Kenny Brock - Auburn AL, US
David Boykin - Atlanta GA, US
Arvind Kumar - Atlanta GA, US
W. David Wilson - Atlanta GA, US
Richard Tidwell - Pittsboro NC, US
Chad Stephens - Villa Roca GA, US

International Classification:

C07D 405/14

US Classification:

544333000, 548305400

Abstract:

The present invention relates to novel compounds and methods that are useful in treating members of the Flaviviridae family of viruses. Compounds of the present invention will have a structure according to Formulas (I)-(VI) as recited throughout the application.

US Patent:

20070010533, Jan 11, 2007

Filed:

Mar 9, 2004

Appl. No.:

10/796657

Inventors:

Christine Dykstra - Auburn AL, US
Maurice Givens - Auburn AL, US
David Stringfellow - Auburn AL, US
Kenny Brock - Auburn AL, US
David Boykin - Atlanta GA, US
Arvind Kumar - Atlanta GA, US
W. Wilson - Atlanta GA, US
Richard Tidwell - Pittsboro NC, US
Chad Stephens - Villa Roca GA, US

International Classification:

A61K 31/506
A61K 31/428
A61K 31/423
A61K 31/4184
C07D 417/14
C07D 413/02
C07D 403/14

US Classification:

514256000, 514367000, 514375000, 514394000, 514397000, 544333000, 548216000, 548305400, 548152000

Abstract:

The present invention relates to novel compounds and methods that are useful in treating members of the Flaviviridae family of viruses. Compounds of the present invention will have a structure according to Formulas (I)-(VI) as recited throughout the application.

US Patent:

20070072877, Mar 29, 2007

Filed:

Nov 20, 2006

Appl. No.:

11/601889

Inventors:

Christine Dykstra - Auburn AL, US
Maurice Givens - Auburn AL, US
David Stringfellow - Auburn AL, US
Kenny Brock - Auburn AL, US
David Boykin - Atlanta GA, US
Arvind Kumar - Atlanta GA, US
W. Wilson - Atlanta GA, US
Richard Tidwell - Pittsboro NC, US
Chad Stephens - Villa Roca GA, US

International Classification:

A61K 31/506
A61K 31/428
A61K 31/423
A61K 31/4184
C07D 417/14
C07D 413/14
C07D 403/14

US Classification:

514256000, 514367000, 514375000, 514394000, 544333000, 548156000, 546217000, 548305400

Abstract:

The present invention relates to novel compounds and methods that are useful in treating members of the Flaviviridae family of viruses. Compounds of the present invention will have a structure according to Formulas (I)-(VI) as recited throughout the application.

US Patent:

20070072878, Mar 29, 2007

Filed:

Nov 20, 2006

Appl. No.:

11/602031

Inventors:

Christine Dykstra - Auburn AL, US
Maurice Givens - Auburn AL, US
David Stringfellow - Auburn AL, US
Kenny Brock - Auburn AL, US
David Boykin - Atlanta GA, US
Arvind Kumar - Atlanta GA, US
W. Wilson - Atlanta GA, US
Richard Tidwell - Pittsboro NC, US
Chad Stephens - Villa Roca GA, US

International Classification:

A61K 31/506
A61K 31/428
A61K 31/423
A61K 31/4184
C07D 417/14
C07D 413/14
C07D 403/14

US Classification:

514256000, 514367000, 514375000, 514394000, 544333000, 548152000, 548216000, 548305400

Abstract:

The present invention relates to novel compounds and methods that are useful in treating members of the Flaviviridae family of viruses. Compounds of the present invention will have a structure according to Formulas (I)-(VI) as recited throughout the application.

US Patent:

20100249175, Sep 30, 2010

Filed:

Jun 29, 2006

Appl. No.:

11/478453

Inventors:

W. David Wilson - Atlanta GA, US
David W. Boykin - Atlanta GA, US
Elizabeth W. White - Atlanta GA, US
Mohamed A. Ismail - Atlanta GA, US
Arvind Kumar - Lilburn GA, US
Rupesh Nanjunda - Atlanta GA, US
Richard R. Tidwell - Pittsboro NC, US

International Classification:

A61K 31/437
C12P 19/34
C12N 5/071
C12N 5/02
A61K 31/4178
C07H 21/04
C07D 471/04
C07D 405/14
A61P 35/04

US Classification:

514300, 435 911, 435366, 435375, 514394, 536 231, 546121, 5483047

Abstract:

Dicationic compounds that are highly selective for binding G-quadruplex DNA are described. Several compounds exhibit groove binding toward G-quadruplex DNA and in vitro and in vivo activity versus The compounds represent novel drugs for the treatment of cancer, malaria, leishmania, and trypanosomiasis.

US Patent:

55941389, Jan 14, 1997

Filed:

May 30, 1995

Appl. No.:

8/453232

Inventors:

Christine C. Dykstra - Chapel Hill NC
Richard R. Tidwell - Chapel Hill NC
David W. Boykin - Atlanta GA
W. David Wilson - Atlanta GA
Jaroslaw Spychala - Poznan, PL
Bijan P. Das - Atlanta GA
Arvind Kumar - Atlanta GA

Assignee:

Georgia State University Research Foundation - Atlanta GA
The University of North Carolina at Chapel Hill - Chapel Hill NC

International Classification:

C07D40500

US Classification:

540596

Abstract:

Disclosed is a method of fluorescent detection of a nucleic acid. The method comprises contacting to the nucleic acid a bis-dicationic aryl furan compound, such as 2,5-bis[4-(4,5,6,7-tetrahydro-1H-1,3-diazepin-2-yl) phenyl] furan; 2,5-bis{[4-(N-isopropyl) amidino] phenyl}furan; and physiologically acceptable salts thereof, and exposing the nucleic acid to light at a frequency to induce fluorescence of the compound. A method for fluorescent detection of cytoskeleton elements, and novel bis-dicationic aryl furan compounds are also disclosed.

US Patent:

56060580, Feb 25, 1997

Filed:

May 31, 1995

Appl. No.:

8/455047

Inventors:

David W. Boykin - Atlanta GA
Christine C. Dykstra - Chapel Hill NC
Richard R. Tidwell - Pittsboro NC
James E. Hall - Chapel Hill NC
W. David Wilson - Atlanta GA
Arvind Kumar - Atlanta GA

Assignee:

The University of North Carolina at Chapel Hill - Chapel Hill NC

International Classification:

C07D23926

US Classification:

544242

Abstract:

The present invention provides compounds useful for treating Pneumocystis carinii pneumonia, Giardia lamblia, and Cryptosporidium parvum in a subject in need of such treatment. The compounds comprise compounds of Formula I: ##STR1##.