Arvind B Kumar

US Patent:

20100249175, Sep 30, 2010

Filed:

Jun 29, 2006

Appl. No.:

11/478453

Inventors:

W. David Wilson - Atlanta GA, US
David W. Boykin - Atlanta GA, US
Elizabeth W. White - Atlanta GA, US
Mohamed A. Ismail - Atlanta GA, US
Arvind Kumar - Lilburn GA, US
Rupesh Nanjunda - Atlanta GA, US
Richard R. Tidwell - Pittsboro NC, US

International Classification:

A61K 31/437
C12P 19/34
C12N 5/071
C12N 5/02
A61K 31/4178
C07H 21/04
C07D 471/04
C07D 405/14
A61P 35/04

US Classification:

514300, 435 911, 435366, 435375, 514394, 536 231, 546121, 5483047

Abstract:

Dicationic compounds that are highly selective for binding G-quadruplex DNA are described. Several compounds exhibit groove binding toward G-quadruplex DNA and in vitro and in vivo activity versus The compounds represent novel drugs for the treatment of cancer, malaria, leishmania, and trypanosomiasis.

US Patent:

56060580, Feb 25, 1997

Filed:

May 31, 1995

Appl. No.:

8/455047

Inventors:

David W. Boykin - Atlanta GA
Christine C. Dykstra - Chapel Hill NC
Richard R. Tidwell - Pittsboro NC
James E. Hall - Chapel Hill NC
W. David Wilson - Atlanta GA
Arvind Kumar - Atlanta GA

Assignee:

The University of North Carolina at Chapel Hill - Chapel Hill NC

International Classification:

C07D23926

US Classification:

544242

Abstract:

The present invention provides compounds useful for treating Pneumocystis carinii pneumonia, Giardia lamblia, and Cryptosporidium parvum in a subject in need of such treatment. The compounds comprise compounds of Formula I: ##STR1##.

US Patent:

55211895, May 28, 1996

Filed:

Sep 13, 1994

Appl. No.:

8/305823

Inventors:

David W. Boykin - Atlanta GA
Christine C. Dykstra - Chapel Hill NC
Richard R. Tidwell - Pittsboro NC
James E. Hall - Chapel Hill NC
W. David Wilson - Atlanta GA
Arvind Kumar - Atlanta GA

Assignee:

The University of NC at CH - Chapel Hill NC

International Classification:

A61K 31505
C07D23926

US Classification:

514256

Abstract:

The present invention provides methods for treating Pneumocystis carinii pneumonia and Giardia lamblia in a subject in need of such treatment. The methods comprises administering to the subject a compound of Formula I: ##STR1## wherein: X and Y are located in the para or meta positions and are selected from the group consisting of H, loweralkyl, loweralkoxy, and ##STR2## wherein: each R. sub. 1 is independently selected from the group consisting of H, loweralkyl, alkoxyalkyl, hydroxyalkyl, aminoalkyl, alkylaminoalkyl, cycloalkyl, aryl, or alkylaryl or two R. sub. 1 groups together represent C. sub. 2 -C. sub. 10 alkyl, hydroxyalkyl, or alkylene, or two R. sub. 1 groups together represent ##STR3## wherein m is from 1-3 and R. sub. 7 is H or --CONHCR. sub. 8 NR. sub. 9 R. sub. 10.

US Patent:

56229550, Apr 22, 1997

Filed:

May 31, 1995

Appl. No.:

8/456164

Inventors:

David W. Boykin - Atlanta GA
Christine C. Dykstra - Chapel Hill NC
Richard R. Tidwell - Pittsboro NC
James E. Hall - Chapel Hill NC
W. David Wilson - Atlanta GA
Arvind Kumar - Atlanta GA
Byron L. Blagburn - Auburn AL

Assignee:

The University of North Carolina at Chapel Hill - Chapel Hill NC
Georgia State University Research Foundation, Inc. - Atlanta GA
Auburn University - Auburn AL

International Classification:

A61K 31505
C07D23926

US Classification:

514256

Abstract:

The present invention provides methods for treating Cryptosporidium parvum in a subject in need of such treatment. The methods comprises administering to the subject a compound of Formula I: ##STR1##.

US Patent:

56021720, Feb 11, 1997

Filed:

May 30, 1995

Appl. No.:

8/453276

Inventors:

David W. Boykin - Atlanta GA
Christine C. Dykstra - Chapel Hill NC
Richard R. Tidwell - Pittsboro NC
James E. Hall - Chapel Hill NC
W. David Wilson - Atlanta GA
Arvind Kumar - Atlanta GA
Byron L. Blagburn - Auburn AL

Assignee:

The University of North Carolina at Chapel Hill - Chapel Hill NC
Auburn University - Auburn AL
Georgia State University Research Foundation, Inc. - Atlanta GA

International Classification:

A61K 3134

US Classification:

514461

Abstract:

The present invention provides methods for treating Pneumocystis carinii pneumonia, Giardia lamblia, and Cryptosporidium parvum in a subject in need of such treatment. The methods comprise adminstering to the subject a compound of Formula (I): ##STR1## wherein: R. sub. 1 and R. sub. 2 are each independently selected from the group consisting of H, loweralkyl, aryl, alkylaryl, aminoalkyl, aminoaryl, halogen, oxyalkyl, oxyaryl, or oxyarylalkyl; R. sub. 3 and R. sub. 4 are each independently selected from the group consisting of H, loweralkyl, oxyalkyl, alkylaryl, aryl, oxyaryl, aminoalkyl, aminoaryl, or halogen; and X and Y are located in the para or meta positions and are selected from the group consisting of H, loweralkyl, oxyalkyl, and ##STR2## wherein: each R. sub. 5 is independently selected from the group consisting of H, loweralkyl, alkoxyalkyl, hydroxyalkyl, aminoalkyl, alkylaminoalkyl, cycloalkyl, aryl, or alkylaryl or two R. sub. 5 groups together represent C. sub. 2 -C. sub.

US Patent:

56271840, May 6, 1997

Filed:

May 31, 1995

Appl. No.:

8/454838

Inventors:

David W. Boykin - Atlanta GA
Christine C. Dykstra - Chapel Hill NC
Richard R. Tidwell - Pittsboro NC
James E. Hall - Chapel Hill NC
W. David Wilson - Atlanta GA
Arvind Kumar - Atlanta GA

Assignee:

The University of North Carolina at Chapel Hill - Chapel Hill NC
Georgia State University Research Foundation, Inc. - Atlanta GA

International Classification:

A61K 31505
C07D23926

US Classification:

514256

Abstract:

The present invention provides methods for treating Pneumocystis carinii pneumonia and Giardia lamblia in a subject in need of such treatment. The methods comprises administering to the subject a compound of Formula I: ##STR1## wherein: X and Y are located in the para or meta positions and are selected from the group consisting of H, loweralkyl, loweralkoxy, and ##STR2## wherein: each R. sub. 1 is independently selected from the group consisting of H, loweralkyl, alkoxyalkyl, hydroxyalkyl, aminoalkyl, alkylaminoalkyl, cycloalkyl, aryl, or alkylaryl or two R. sub. 1 groups together represent C. sub. 2 -C. sub. 10 alkyl, hydroxyalkyl, or alkylene, or two R. sub. 1 groups together represent ##STR3## wherein m is from 1-3 and R. sub. 7 is H or --CONHCR. sub. 8 NR. sub. 9 R. sub. 10, wherein R. sub.

US Patent:

56864566, Nov 11, 1997

Filed:

Nov 28, 1995

Appl. No.:

8/564879

Inventors:

David W. Boykin - Atlanta GA
Christine C. Dykstra - Chapel Hill NC
Richard R. Tidwell - Pittsboro NC
James E. Hall - Chapel Hill NC
W. David Wilson - Atlanta GA
Arvind Kumar - Atlanta GA

Assignee:

The University of North Carolina - Chapel Hill NC
Georgia State University Research Foundation, Inc. - Atlanta GA
Auburn University - Auburn AL

International Classification:

A61K 31505
C07D23926

US Classification:

514256

Abstract:

The present invention provides methods for treating Pneumocystis carinii pneumonia in a subject in need of such treatment. The methods comprise administering to a subject in need thereof, a pyrimidine of Formula I. ##STR1## wherein the variables are as defined in the specification.

US Patent:

20230105108, Apr 6, 2023

Filed:

Dec 18, 2020

Appl. No.:

17/757644

Inventors:

- Atlanta GA, US
David W. BOYKIN - Atlanta GA, US
Arvind KUMAR - Lilburn GA, US
Mengyuan ZHU - Cary NC, US
Manjusha ROY CHOUDHURY - Atlanta GA, US
Bingchen YU - Atlanta GA, US

Assignee:

GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. - Atlanta GA

International Classification:

A61K 31/155
C07D 307/52
C07D 307/54
C07D 403/04
C07C 257/18
C07D 239/06
C07C 323/45
C07D 233/20
C07C 279/18
C07D 405/04
C07D 333/20
C07D 307/68
C07D 409/14
C07D 345/00
A61K 31/704
A61K 31/7048
A61K 31/496
A61K 31/7052
A61K 31/437
A61K 31/7056
A61K 31/575
A61K 38/12
A61K 31/165
A61K 31/4375
A61K 31/55
A61K 31/4709
A61K 31/5383
A61K 31/43
A61K 31/431
A61K 31/407
A61K 31/65
A61K 31/505
A61K 31/702
C07D 235/18
C07D 409/04
C07D 213/30
C07D 233/22
C07C 219/28
C07D 333/22
A61K 31/4184
A61K 31/137
A61K 31/277
A61K 31/506
A61K 31/4178
A61K 31/341
A61K 31/381
A61K 31/33
A61K 31/44
A61P 31/04

Abstract:

Compounds and methods for use to treat a bacterial infection caused by, for example, gram positive bacteria, gram negative bacteria, and/or mycobacteria are provided herein. Also provided herein are compounds and methods for use in potentiating the effect of an antibiotic in the treatment of a bacterial infection. Pharmaceutical compositions including the compounds as described herein are also provided.