Avi Lane Friedlich

US Patent:

20100151520, Jun 17, 2010

Filed:

Dec 15, 2009

Appl. No.:

12/638494

Inventors:

Jack Rogers - Arlington MA, US
Avi Friedlich - Charlestown MA, US

International Classification:

C12P 21/02
C07H 21/00
C12N 15/74
C12N 5/10

US Classification:

435 691, 536 231, 4353201, 435325

Abstract:

The invention relates to translation enhancer elements that enhance translation of the gene encoding the human microtubule-associated tau protein and nucleic acid molecules that enhance translation of the gene encoding the human α-synuclein protein. The translation enhancer elements of the invention are useful in compositions and methods for identifying compounds for the prevention and/or treatment of neurodegenerative disease. The invention also includes in some aspects, vectors that include a translation enhancer element of the invention. The invention also includes the use of enhancer element containing vectors in methods to produce recombinant protein and in assays to identify compounds that modulate expression of tau protein or α-synuclein protein.

US Patent:

20080003570, Jan 3, 2008

Filed:

Dec 22, 2005

Appl. No.:

11/316339

Inventors:

Jack Rogers - Arlington MA, US
Avi Friedlich - Brockton MA, US

Assignee:

The General Hospital Corporation - Boston MA

International Classification:

C12Q 1/68
C07H 21/00
C07K 2/00
C12N 1/00
C12N 15/63
C12N 5/10
C12P 21/02

US Classification:

435006000, 435243000, 435320100, 435325000, 435069100, 530300000, 536023100

Abstract:

The invention relates to translation enhancer elements that enhance translation of the gene encoding the human microtubule-associated tau protein and nucleic acid molecules that enhance translation of the gene encoding the human α-synuclein protein. The translation enhancer elements of the invention are useful in compositions and methods for identifying compounds for the prevention and/or treatment of neurodegenerative disease. The invention also includes in some aspects, vectors that include a translation enhancer element of the invention. The invention also includes the use of enhancer element containing vectors in methods to produce recombinant protein and in assays to identify compounds that modulate expression of tau protein or α-synuclein protein.

US Patent:

20150342985, Dec 3, 2015

Filed:

Dec 27, 2013

Appl. No.:

14/758020

Inventors:

Avi FRIEDLICH - Quincy MA, US
Avi Friedlich - Quincy MA, US

International Classification:

A61K 33/00
A61K 31/513
A61K 33/14

Abstract:

This invention relates to compositions comprising lithium and methods of their use.