Axel H Metzger from 177 S Stump Tavern Rd, Jackson Twp, NJ 08527, age 62, Phone: (848)2224901

Axel Metzger - Lawyer

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Office:

Baker & McKenzie

ISLN:

922400101

Rechtsgeschafte uber Das Droit Moral Im Deutschen Und Franzosischen Urheberrecht

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Author
Axel Metzger

ISBN #
3406487890

Consultant At Advanced Proteome Therapeutics Inc.

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Position:

Consultant at Advanced Proteome Therapeutics Inc.

Location:

Greater Boston Area

Industry:

Pharmaceuticals

Work:

Advanced Proteome Therapeutics Inc. since Feb 2012
Consultant
Palatin Technologies Dec 2006 - Oct 2010
Associate Director
Pharmacopeia 2002 - 2006
Reserach Fellow
Pharmacopeia Drug Discovery, Inc. Jul 1997 - Nov 2006
Senior Research Fellow
UT at Austin 1995 - 1997
Post Doc

Education:

Villanova University 2011 - 2011
Master Certificate, Applied Project Management; Technische Universität München

Skills:

Drug Discovery
Medicinal Chemistry
Lead Change
Drug Development
Drug Design
Organic Synthesis
Organic Chemistry
GPCRs
Biotechnology
HPLC
LC-MS
ADME

Languages:

English, German

Axel Metzger

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Us Patents

N-Heterocyclic Inhibitors Of Tnf-Α Expression
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US Patent:

6906067, Jun 14, 2005
Filed:

Jun 26, 2001
Appl. No.:

09/891750
Inventors:

Kevin Joseph Moriarty - Norristown PA, US
Yvonne Shimshock - Hillsborough NJ, US
Gulzar Ahmed - Yardley PA, US
Junjun Wu - Malden MA, US
James Wen - Dayton NJ, US
Wei Li - Acton MA, US
Shawn David Erickson - Leonia NJ, US
Jeffrey John Letourneau - East Windsor NJ, US
Edward McDonald - Banstead, GB
Katerina Leftheris - Skillman NJ, US
Stephen T. Wrobleski - Whitehouse Station NJ, US
Zahid Hussain - Monmouth Junction NJ, US
Ian Henderson - Hopewell NJ, US
Axel Metzger - East Windsor NJ, US
John J. Baldwin - Gwynedd Valley PA, US
Alaric J. Dyckman - Lawrenceville NJ, US
Assignee:

Bristol-Myers Squibb Company - Princeton NJ
Pharmaceopeia, Inc. - Cranbury NJ
International Classification:

C07D251/40
C07D251/48
C07D251/52
A61K031/53
A61P035/00
US Classification:

514241, 544197, 544198, 544208, 544209, 544213, 544217, 544218
Abstract:

N-heterocyclic compounds that block cytokine production via inhibition of p38 kinase are disclosed. In one embodiment, compounds of the present invention are represented by Formula I: Methods of production, pharmaceutical compositions and methods of treating conditions associated with inappropriate p38 kinase activity or TNF-α expression utilizing compounds of the present invention are also disclosed.

N-Heterocyclic Inhibitors Of Tnf-Α Expression
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US Patent:

7253174, Aug 7, 2007
Filed:

Jul 12, 2006
Appl. No.:

11/485075
Inventors:

Gulzar Ahmed - Yardley PA, US
Axel Metzger - East Windsor NJ, US
Ian Henderson - Hopewell NJ, US
David J. Diller - Hightstown NJ, US
Jun Wen - Dayton NJ, US
Stephen T. Wrobleski - Whitehouse Station NJ, US
Katerina Leftheris - Skillman NJ, US
Chunjian Liu - Pennington NJ, US
Assignee:

Bristol-Myers Squibb Company - Princeton NJ
Pharmacopeia, Inc. - Cranbury NJ
International Classification:

C07D 239/48
A61K 31/505
US Classification:

514256, 514275, 544323, 544324, 544326, 544328, 544329
Abstract:

N-heterocyclic compounds that block cytokine production via inhibition of p38 kinase are disclosed. In one embodiment, compounds of the present invention are represented by Formula (I):Methods of production, pharmaceutical compositions and methods of treating conditions associated with inappropriate p38 kinase activity or TNF-α expression utilizing compounds of the present invention are also disclosed.

N-Heterocyclic Inhibitors Of Tnf-Α Expression
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US Patent:

7479495, Jan 20, 2009
Filed:

Jun 2, 2005
Appl. No.:

11/143430
Inventors:

Kevin Joseph Moriarty - Norristown PA, US
Yvonne Shimshock - Hillsborough NJ, US
Gulzar Ahmed - Yardley PA, US
Junjun Wu - Malden MA, US
James Wen - Dayton NJ, US
Wei Li - Acton MA, US
Shawn David Erickson - Leonia NJ, US
Jeffrey John Letourneau - East Windsor NJ, US
Edward McDonald - Banstead, GB
Katerina Leftheris - Skillman NJ, US
Stephen T. Wrobleski - Whitehouse Station NJ, US
Zahid Hussain - Monmouth Junction NJ, US
Ian Henderson - Hopewell NJ, US
Axel Metzger - East Windsor NJ, US
John J. Baldwin - Gwynedd Valley PA, US
Alaric J. Dyckman - Lawrenceville NJ, US
Assignee:

Pharmacopeia, Inc. - Cranbury NJ
Bristol-Myers Squibb Company - Princeton NJ
International Classification:

C07D 239/32
C07D 239/48
C07D 239/50
C07D 401/04
C07D 401/12
C07D 403/04
C07D 403/12
A61K 31/505
A61K 31/506
A61P 19/02
A61P 35/00
US Classification:

514269, 514272, 514273, 514275, 544317, 544320, 544321, 544323, 544326
Abstract:

N-heterocyclic compounds that block cytokine production via inhibition of p38 kinase are disclosed. In one embodiment, compounds of the present invention are represented by Formula I:Methods of production, pharmaceutical compositions and methods of treating conditions associated with inappropriate p38 kinase activity or TNF-α expression utilizing compounds of the present invention are also disclosed.

8-Heteroarylpurine Mnk2 Inhibitors For Treating Metabolic Disorders
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US Patent:

7951803, May 31, 2011
Filed:

Mar 9, 2007
Appl. No.:

11/684262
Inventors:

Andrew G. Cole - Robbinsville NJ, US
Joan J. Zhang - Plainsboro NJ, US
Zahid Hussain - Monmouth Junction NJ, US
David J. Diller - East Windsor NJ, US
Axel Metzger - East Windsor NJ, US
Gulzar Ahmed - Voorhees NJ, US
Ian Henderson - Hopewell NJ, US
Assignee:

Pharmacopeia, LLC - San Diego CA
International Classification:

C07D 473/32
A61K 31/52
A61P 3/10
A61P 3/04
A61P 19/02
C07D 409/12
C07D 239/26
C07D 239/28
US Classification:

5142342, 51425216, 51426321, 51426322, 51426323, 5142634, 544118, 544277, 544162, 544324, 544326, 544332, 546232
Abstract:

Compounds of the formula.

Melanocortin Receptor-Specific Spiro-Piperidine Compounds
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US Patent:

8263608, Sep 11, 2012
Filed:

Mar 29, 2011
Appl. No.:

13/074070
Inventors:

Yi-Qun Shi - East Brunswick NJ, US
John H. Dodd - Flemington NJ, US
Elizabeth G. Rowley - Kendal Park NJ, US
Gary L. Olson - Mountainside NJ, US
Axel Metzger - East Windsor NJ, US
Assignee:

Palatin Technologies, Inc. - Cranbury NJ
International Classification:

A61K 31/415
A61K 31/445
A61K 31/454
A61K 31/4545
C07D 221/00
C07D 233/00
US Classification:

514278, 514323, 546 15, 546 17, 546 18, 546184, 546192, 5483001
Abstract:

Melanocortin receptor-specific compounds of formula I below:.

N-Heterocyclic Inhibitors Of Tnf-Alpha Expression
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US Patent:

8044040, Oct 25, 2011
Filed:

Jul 16, 2007
Appl. No.:

11/778219
Inventors:

Gulzar Ahmed - Yardley PA, US
Axel Metzger - East Windsor NJ, US
Ian Henderson - Hopewell NJ, US
David J. Diller - Hightstown NJ, US
Jun Wen - Dayton NJ, US
Stephen T. Wrobleski - Whitehouse Station NJ, US
Katerina Leftheris - Skillman NJ, US
Chunjian Liu - Pennington NJ, US
Assignee:

Bristol-Myers Squibb Company - Princeton NJ
Pharmacopeia, Inc. - Cranbury NJ
International Classification:

C07D 239/48
A61K 31/505
US Classification:

514218, 514256, 514274, 514275, 540575, 544317, 544323, 544324, 544326, 544328, 544329
Abstract:

N-heterocyclic compounds that block cytokine production via inhibition of p38 kinase are disclosed. In one embodiment, compounds of the present invention are represented by Formula (I):.

N-Heterocyclic Inhibitors Of Tnf-Alpha Expression
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US Patent:

20030139435, Jul 24, 2003
Filed:

Jun 26, 2002
Appl. No.:

10/183179
Inventors:

Gulzar Ahmed - Yardley PA, US
Axel Metzger - East Windsor NJ, US
Ian Henderson - Hopewell NJ, US
David Diller - Hightstown NJ, US
James Wen - Dayton NJ, US
Stephen Wrobleski - Whitehouse Station NJ, US
Katerina Leftheris - Skillman NJ, US
International Classification:

A61K031/506
A61K031/505
C 07D 4 1/02
C 07D 4 3/02
A61K031/4439
US Classification:

514/275000, 514/352000, 514/336000, 544/330000, 544/331000, 546/268100, 546/308000
Abstract:

N-heterocyclic compounds that block cytokine production via inhibition of p38 kinase are disclosed. In one embodiment, compounds of the present invention are represented by Formula (I): Methods of production, pharmaceutical compositions and methods of treating conditions associated with inappropriate p38 kinase activity or TNF- expression utilizing compounds of the present invention are also disclosed.

Substituted 2-Aminothiazoles For Treating Neurodegenerative Diseases
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US Patent:

20090005568, Jan 1, 2009
Filed:

Aug 18, 2006
Appl. No.:

11/465569
Inventors:

Andrew G. Cole - Robbinsville NJ, US
Axel Metzger - East Windsor NJ, US
Ian Henderson - Hopewell NJ, US
Assignee:

Pharmacopeia Drug Discovery, Inc. - Cranbury NJ
International Classification:

A61K 31/454
A61K 31/427
C07D 277/02
C07D 401/04
A61P 25/28
US Classification:

546209, 548194, 514370, 514326
Abstract:

The invention relates to substituted 2-aminothiazole derivatives useful in treating disorders that are mediated by Areceptor function, including neurodegenerative diseases including Parkinson's disease and inflammation. The compounds have general formula I: