Azra R Raza

US Patent:

20060228700, Oct 12, 2006

Filed:

Mar 21, 2006

Appl. No.:

11/385978

Inventors:

Azra Raza - Worcester MA, US
Harvey Preisler - , US

International Classification:

C12Q 1/70
A61K 38/21
A61K 31/522

US Classification:

435005000, 424085500, 424085600, 424085700, 514263320

Abstract:

The present invention relates first, to the identification of a novel retrovirus and the novel nucleotide sequences encoding a retroviral polymerase gene (POL nucleotides) associated with the existence of MDS and MDS associated disorders. The present invention further relates to methods for using the MDS associated retroviral nucleotides for the detection of MDS and MDS associated disorders in patient samples. The present invention also relates to methods for using and targeting the MDS associated retroviral POL nucleotides in gene therapy protocols for the treatment of MDS and MDS associated disorders in patients in need of such treatment. The present invention further relates to diagnostic protocols and kits for the detection of MDS and MDS associated disorders in tissue samples.

US Patent:

20150313859, Nov 5, 2015

Filed:

Dec 6, 2013

Appl. No.:

14/649759

Inventors:

Manjo MANIAR - Freemont CA, US
Azra RAZA - New York NY, US
Francois WILHELM - Princeton NJ, US
- NEWTOWN NJ, US
- New York NY, US

Assignee:

ONCONOVA THERAPEUTICS, INC. - NEWTOWN NJ
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK - New York NY

International Classification:

A61K 31/198
A61K 31/454
A61K 31/706
A61K 45/06
A61K 47/10

Abstract:

The invention discloses a method of treating cancer refractory to an anticancer agent comprising administering to a cancer patient a pharmaceutical composition comprising at least one compound of Formula 1Where Ris selected from the group consisting of —NH, —NH—CH—COOH, —NH—CH(CH)—COOH, —NH—C(CH)—COOH, —NH—CH—CH—OH and —N—(CHCHOH)or a pharmaceutically acceptable salt of such a compound, and an anticancer agent.