Babak Borhan

US Patent:

6787671, Sep 7, 2004

Filed:

Jan 13, 2003

Appl. No.:

10/341499

Inventors:

Babak Borhan - East Lansing MI
Benjamin R. Travis - Lansing MI
Jennifer M. Schomaker - Mt. Pleasant MI

Assignee:

Board of Trustees of Michigan State University - East Lansing MI

International Classification:

C07C 4500

US Classification:

568314, 568317, 568356, 568398, 568430, 568435, 568485, 5625122, 562521, 562531, 562535, 560114, 560115, 560207, 560210

Abstract:

An osmium-assisted process for the oxidative cleavage of oxidizable organic compounds such as unsaturated organic compounds, including alkenes and olefins into aldehydes, carboxylic acids, esters, or ketones. The process uses a metal catalyst comprising osmium and a peroxy compound selected from the group consisting of peroxymonosulfuric acid and salts thereof to oxidatively cleave the oxidizable organic compound. In particular, the process enables aldehydes, carboxylic acids, esters, or ketones to be selectively produced from the corresponding mono-, 1,1-di-, 1,2-di-, tri-, or tetra-substituted olefins in a reaction that produces the result of ozonolysis but with fewer problems. The present invention further provides a process for oxidizing an aldehyde alone or with the osmium in an interactive solvent to produce an ester or carboxylic acid.

US Patent:

20070117782, May 24, 2007

Filed:

Dec 1, 2006

Appl. No.:

11/566171

Inventors:

Bruce Hammock - Davis CA, US
Jiang Zheng - Seattle WA, US
Christophe Morisseau - Davis CA, US
Kazuhiko Motoba - Kawachinagano, JP
Mehran Moghaddam - San Diego CA, US
Babak Borhan - East Lansing MI, US
David Grant - Storrs CT, US
Jessica Greene - Oakland CA, US
Marlene Sisemore - Davis CA, US
James Sanborn - Sacramento CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A61K 31/66
A61K 31/17

US Classification:

514114000, 514580000, 514588000

Abstract:

The invention provides compounds that inhibit epoxide hydrolase in therapeutic applications for treating hypertension. A preferred class of compounds for practicing the invention have the structure shown by Formula 1 wherein Z is oxygen or sulfur, W is carbon phosphorous or sulfur, X and Y is each independently nitrogen, oxygen, or sulfur, and X can further be carbon, at least one of R-Ris hydrogen, Ris hydrogen when X is nitrogen but is not present when X is sulfur or oxygen, Ris hydrogen when Y is nitrogen but is not present when Y is sulfur or oxygen, Rand Ris each independently C-Csubstituted or unsubstituted alkyl, cycloalkyl, aryl, acyl, or heterocyclic.

US Patent:

20090012120, Jan 8, 2009

Filed:

May 9, 2007

Appl. No.:

11/801395

Inventors:

Babak Borhan - East Lansing MI, US
Jennifer M. Schomaker - Berkeley CA, US
Somnath Bhattacharjee - East Lansing MI, US
Keith Korthals - East Lansing MI, US

Assignee:

Board of Trustees of Michigan State University - East Lansing MI

International Classification:

A61K 31/4015
C07D 207/12
C07D 209/32
C07D 209/54
C07C 211/00
C07D 211/00
A61P 35/00
A61K 31/13
A61K 31/403
A61K 31/445

US Classification:

514315, 548556, 548541, 548512, 548408, 564463, 546184, 514579, 514409, 514412, 514424

Abstract:

An ylide-based aza-Payne rearrangement of 2,3-aziridin--ols leads to an efficient process for the preparation of pyrrolidines. The aza-Payne rearrangement under the basic reaction conditions favors the formation of epoxy amines. Subsequent nucleophilic attack of the epoxide by the ylide yields a bis-anion, which upon a 5-exo-tet ring closure yields the desired pyrrolidine, thus completing the relay of the 3-membered the 5-membered nitrogen containing ring system. This process takes place with complete transfer of stereochemical fidelity, and can be applied to sterically hindered aziridinols.

US Patent:

20130157284, Jun 20, 2013

Filed:

Mar 23, 2011

Appl. No.:

13/636499

Inventors:

Babak Borhan - Okemos MI, US
James Geiger - Webberville MI, US
Wenjing Wang - Cambridge MA, US
Chrysoula Vasileiou - East Langsing MI, US
Kin Sing Lee - Davis CA, US
Tetyana Berbasova - East Lansing MI, US

Assignee:

Board of Trustees of Michigan State University - East Lansing MI

International Classification:

C07K 14/47
G01N 33/58

US Classification:

435 71, 536 235, 536 234, 4353201, 4352523, 43525411, 4352542, 435325, 435348, 435419, 43525233, 43525231, 43525235, 43525234, 435365, 435358, 435357, 435367, 435352, 43525421, 43525423, 4352543, 4352546, 435370, 435366, 530350, 530410, 530409, 4352831

Abstract:

The invention relates to intracellular lipid binding proteins that bind retinoids and/or dye ligands and that are modified to transmit or emit light at a variety of different wavelengths.

US Patent:

59554967, Sep 21, 1999

Filed:

Aug 12, 1997

Appl. No.:

8/909523

Inventors:

Bruce D. Hammock - Davis CA
Mehran F. Moghaddam - Wilmington DE
Jeffrey M. Cheek - Sacramento CA
Babak Borhan - New York NY
James Fergusson - Davis CA
David F. Grant - Little Rock AK
Jessica F. Greene - Davis CA
Kazuhiko Matoba - Osaka, JP
Jiang Zheng - Davis CA
Marlene F. Sisemore - Davis CA

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A61K 3134
C07D30712

US Classification:

514473

Abstract:

The present invention provides novel biologically active tetrahydrofuran diols of arachidonic acid.

US Patent:

61746959, Jan 16, 2001

Filed:

May 14, 1999

Appl. No.:

9/312207

Inventors:

Bruce D. Hammock - Davis CA
Mehran F. Moghaddam - Wilmington DE
Jeffrey M. Cheek - Sacramento CA
Babak Borhan - New York NY
James Fergusson - Davis CA
David F. Grant - Little Rock AR
Jessica F. Greene - Davis CA
Kazuhiko Matoba - Osaka, JP
Jiang Zheng - Davis CA
Marlene F. Sisemore - Davis CA

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

C12Q 134

US Classification:

435 18

Abstract:

The present invention provides methods of treating inflammatory diseases mediated by poly-unsaturated lipid metabolites by inhibiting epoxide hydrolase, methods for assaying or screening the epoxide hydrolase inhibitors for inhibitory specificity and for toxicity, and novel biologically active tetrahydrofuran diols of arachidonic acid, including antibodies thereto.

US Patent:

20230033629, Feb 2, 2023

Filed:

Jul 18, 2022

Appl. No.:

17/867022

Inventors:

- , US
Chenchen YANG - Holt MI, US
Babak BORHAN - Okemos MI, US
Mehdi MOEMENI - Okemos MI, US
Matthew BATES - East Lansing MI, US

Assignee:

Board of Trustees of Michigan State University - East Lansing MI

International Classification:

H01L 31/055
H01L 31/048
H01L 31/054

Abstract:

A transparent luminescent solar concentrator (TLSC) is provided. The TLSC includes a luminophore and a waveguide that guides light emitted from the luminophore. The TLSC has a light utilization efficiency (LUE) of greater than or equal to about 1.