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Babu J Mavunkel

age ~77

from Sunnyvale, CA

Also known as:
  • Babu Joseph Mavunkel
  • Babu Mavunkel
  • Babu Mathew
  • Babu Mavunkal
  • Navunkel Babu
  • Joseph Mavunkel Mavunkel
Phone and address:
1348 Avoset Ter, Sunnyvale, CA 94087
(408)2458579

Babu Mavunkel Phones & Addresses

  • 1348 Avoset Ter, Sunnyvale, CA 94087 • (408)2458579
  • 705 Republican St, Seattle, WA 98102 • (206)3256437
  • Timonium, MD
  • Baltimore, MD
  • Pleasanton, CA

Work

  • Company:
    Johnson & johnson fremont ca
    2003 to 2007
  • Position:
    Research fellow

Education

  • Degree:
    Doctorates, Doctor of Philosophy
  • School / High School:
    Goethe University
    1973 to 1978
  • Specialities:
    Organic Chemistry

Emails

Industries

Biotechnology

Resumes

Babu Mavunkel Photo 1

Babu Mavunkel

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Location:
Sunnyvale, CA
Industry:
Biotechnology
Work:
Johnson & Johnson Fremont Ca 2003 - 2007
Research Fellow

Scios 1992 - 2003
Research Fellow

Nova Pharmaceuticals 1984 - 1992
Staff Scientist
Education:
Goethe University 1973 - 1978
Doctorates, Doctor of Philosophy, Organic Chemistry
University of Frankfurt
Doctorates, Doctor of Philosophy, Organic Chemistry

Us Patents

  • Compounds And Methods To Treat Cardiac Failure And Other Disorders

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  • US Patent:
    6340685, Jan 22, 2002
  • Filed:
    Mar 24, 1999
  • Appl. No.:
    09/275176
  • Inventors:
    Babu J. Mavunkel - Sunnyvale CA
    John A. Lewicki - Los Gatos CA
    David Y. Liu - Palo Alto CA
    George F. Schreiner - Los Altos Hills CA
    John J. Perumattam - Los Altos CA
  • Assignee:
    Scios, Inc. - Sunnyvale CA
  • International Classification:
    A61K 31496
  • US Classification:
    514253, 544367, 544370, 544373
  • Abstract:
    A compound of the formula: and the pharmaceutically acceptable salts thereof, wherein each of Z and Z is independently CR or N; where each R is independently H or is alkyl (1-6C) optionally including one or more heteroatoms selected from O, S and N and optionally substituted by one or more of halo, OR, SR, NR , RCO, COOR, CONR , OOCR, or NROCR where R is H or alkyl (1-6C), or by CN or O, or by an aliphatic or aromatic 5 or 6 membered ring optionally containing 1-2 N heteroatoms; or two R taken together form a bridge optionally containing a heteroatom; R is  wherein X is CO or an isostere thereof; m is 0 or 1; Y is optionally substituted alkyl, optionally substituted aryl, or optionally substituted arylalkyl or two 6 taken together may form an alkyene (2-3C) bridge; n is 0 or 2; Z is CH or N; X is CH, CH or an isostere thereof; and Ar consists of one or two phenyl moieties directly coupled to X optionally substituted by halo, nitro, alkyl (1-6C), alkenyl (1-6C), CN or CF , or by RCO, COOR, CONR , NR , OR, SR, OOCR or NROCR wherein R is H or alkyl (1-6C) or by phenyl, itself optionally substituted by the foregoing substituents; R is H, or alkyl (1-6C) optionally including one heteroatom which is O, S or N, and optionally substituted by one or more of halo, OR, SR, NR , RCO, COOR, CONR , OOCR, or NROCR where R is H or alkyl (1-6C), or by CN or O, or by an aliphatic or aromatic 5 or 6 membered ring optionally containing 1-2 N heteroatoms; R is H, halo, NO , alkyl (1-6C), alkenyl (1-6C), CN, OR, SR, NR , RCO, COOR, CONR , OOCR, or NROCR where R is H or alkyl (1-6C).
  • Inhibitors Of P38-Kinase

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  • US Patent:
    6410540, Jun 25, 2002
  • Filed:
    Aug 27, 1999
  • Appl. No.:
    09/385494
  • Inventors:
    R. Richard Goehring - Pipersville PA
    Gregory R. Luedtke - Sunnyvale CA
    Babu J. Mavunkel - Sunnyvale CA
    Sarvajit Chakravarty - Sunnyvale CA
    Sundeep Dugar - Bridgewater NJ
    George F. Schreiner - Los Altos Hills CA
    David Y. Liu - Palo Alto CA
    John A. Lewicki - Los Gatos CA
  • Assignee:
    Scios, Inc. - Sunnyvale CA
  • International Classification:
    A61K 3150
  • US Classification:
    51425213, 51425409, 514330
  • Abstract:
    The invention is directed to methods to treat conditions mediated by p38-kinase using compounds of the formula and the pharmaceutically acceptable salts thereof, or a pharmaceutical composition thereof, wherein Z is N or CR , R is a noninterfering substituent, each of X and X is a linker, Ar and Ar are identical or different, and represent optionally substituted C1-C20 hydrocarbyl residues wherein at least one of Ar and Ar is an optionally substituted aryl group, with the proviso that when X is CH or an isostere thereof, X is CO or an isostere thereof, and Ar is optionally substituted phenyl, Ar is other than an optionally substituted indolyl, benzimidazolyl or benzotriazolyl substituent, and wherein said optionally substituted phenyl is not an optionally substituted indolyl, benzimidazolyl, or benzotriazolyl, Y is a noninterfering substituent, wherein n is an integer from 0-4, and wherein m is an integer from 0-4 and 1 is an integer from 0-3.
  • Compounds And Methods To Treat Cardiac Failure And Other Disorders

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  • US Patent:
    6448257, Sep 10, 2002
  • Filed:
    Mar 24, 2000
  • Appl. No.:
    09/535316
  • Inventors:
    Babu J. Mavunkel - Sunnyvale CA
    David Y. Liu - Palo Alto CA
    George F. Schreiner - Los Altos Hills CA
    John A. Lewicki - Los Gatos CA
  • Assignee:
    Scios, Inc. - Sunnyvale CA
  • International Classification:
    A61K 31437
  • US Classification:
    514292, 546 89
  • Abstract:
    Compounds of the formula: wherein the dotted line represents an optional bond; and the pharmaceutically acceptable salts thereof, wherein X is an alkyl bridge optionally containing an O, S, or N heteroatom that forms an aliphatic 5-7 membered ring and is optionally substituted by one or more of halo, OR, SR, NR , RCO, COOR, CONR , OOCR, or NROCR where R is H or alkyl (1-6C), or by one or more CN or O, or by one or more aliphatic or aromatic 5- or 6-membered rings optionally containing 1-2 heteroatoms; R is  wherein X is CO or an isostere thereof; m is 0 or 1; Y is optionally substituted alkyl, optionally substituted aryl, or optionally substituted arylalkyl or two Y taken together may form an alkylene (2-3C) bridge; n is 0-4; Z is CH or N; X is CH or CHR where R is H or alkyl (1-6C), or an isostere thereof; and Ar, R and R are as defined in the specification. These compounds are selective inhibitors of p38 kinase.
  • Inhibitors Of P38-A Kinase

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  • US Patent:
    6541477, Apr 1, 2003
  • Filed:
    Feb 28, 2001
  • Appl. No.:
    09/796997
  • Inventors:
    R. Richard Goehring - Pipersville PA
    Babu J. Mavunkel - Sunnyvale CA
    David Y. Liu - Palo Alto CA
    George F. Schreiner - Los Altos Hills CA
    Gregory Leudtke - Sunnyvale CA
    John A. Lewicki - Los Gatos CA
  • Assignee:
    Scios, Inc. - Sunnyvale CA
  • International Classification:
    A61K 31495
  • US Classification:
    51425213, 5142541, 514330
  • Abstract:
    The invention is directed to methods for treating conditions mediated by by P38 kinase using compounds of the formula wherein Ar and Ph are limited to specific embodiments or wherein the compound of formula (3) is a compound set forth in FIGS. A- T.
  • Compounds And Methods To Treat Cardiac Failure And Other Disorders

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  • US Patent:
    6589954, Jul 8, 2003
  • Filed:
    May 21, 1999
  • Appl. No.:
    09/316761
  • Inventors:
    Babu J. Mavunkel - Sunnyvale CA
    David Y. Liu - Palo Alto CA
    George F. Schreiner - Los Altos Hills CA
    John A. Lewicki - Los Gatos CA
    John J. Perumattam - Los Altos CA
  • Assignee:
    Scios, Inc. - Sunnyvale CA
  • International Classification:
    A61K 31495
  • US Classification:
    514253, 544367, 544373
  • Abstract:
    Indoles, benzimidazoles and benztriazoles which are substituted at the 5 or 6 position with a substituent comprising an aromatic moiety linked through a piperazine ring to said indole, benzimidazole or benztriazole are useful in treating cardiac conditions associated with heart failure and in treating conditions characterized by proinflammation.
  • Piperidine/Piperazine-Type Inhibitors Of P38 Kinase

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  • US Patent:
    6696443, Feb 24, 2004
  • Filed:
    Nov 20, 2001
  • Appl. No.:
    09/990184
  • Inventors:
    Babu Mavunkel - Sunnyvale CA
    Sundeep Dugar - San Jose CA
    Gregory Luedtke - Sunnyvale CA
    Xuefei Tan - Sunnyvale CA
    Glenn McEnroe - San Mataeo CA
  • Assignee:
    Scios, Inc. - Fremont CA
  • International Classification:
    C07D40106
  • US Classification:
    514241, 544180, 544182, 544236, 544238, 544257, 544279, 544333, 544350, 546114, 546115, 546121, 546122, 546139, 546194, 546199, 546208, 546202, 546209, 546211, 546212, 546214, 514242, 514248, 51425203, 51425505, 5142593, 5142592, 51425941, 514256, 514300, 514301, 514302, 514314, 514318, 514319, 514320, 514321, 514322, 514323, 514324, 514326
  • Abstract:
    Certain compounds which contain a piperidine moiety flanked by aryl groups are inhibitors of p38- kinase and thus useful in the treatment of a variety of conditions characterized by inappropriate p38- kinase activity.
  • Indole-Type Derivatives As Inhibitors Of P38 Kinase

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  • US Patent:
    6864260, Mar 8, 2005
  • Filed:
    May 28, 2002
  • Appl. No.:
    10/157048
  • Inventors:
    Babu J. Mavunkel - Sunnyvale CA, US
    Sarvajit Chakravarty - Sunnyvale CA, US
    John J. Perumattam - Los Altos CA, US
    Sundeep Dugar - San Jose CA, US
    Qing Lu - Foster City CA, US
    Xi Liang - Mountain View CA, US
  • Assignee:
    Scios, Inc. - Fremont CA
  • International Classification:
    A61K031/495
    C07D403/06
  • US Classification:
    514253, 544367, 544370, 544373
  • Abstract:
    The invention is directed to methods to inhibit p-α kinase using compounds which contain a phenyl group linked through a piperazine ring to a substituted indole.
  • Indole-Type Derivatives As Inhibitors Of P38 Kinase

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  • US Patent:
    6867209, Mar 15, 2005
  • Filed:
    May 19, 2000
  • Appl. No.:
    09/575060
  • Inventors:
    Babu J. Mavunkel - Sunnyvale CA, US
    Sarvajit Chakravarty - Sunnyvale CA, US
    John J. Perumattam - Los Altos CA, US
    Sundeep Dugar - San Jose CA, US
    Qing Lu - Foster City CA, US
    Xi Liang - Mountain View CA, US
  • Assignee:
    Scios, Inc. - Freemont CA
  • International Classification:
    A61K031/495
    C07D241/04
  • US Classification:
    514253, 514183, 5142328, 5142352, 5142358, 540481, 544121, 544142, 544363, 544396
  • Abstract:
    The invention is directed to methods to inhibit p38-α kinase using compounds of the formula.
Name / Title
Company / Classification
Phones & Addresses
Babu Mavunkel
President
C.W.E. OWNERS ASSOCIATION
Business Services · Civic/Social Association
1360 Avoset Ter, Sunnyvale, CA 94087
1311 Avoset Ter, Sunnyvale, CA 94087

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