Barry M Jacobson

US Patent:

20040044225, Mar 4, 2004

Filed:

Jul 3, 2003

Appl. No.:

10/296875

Inventors:

James Kanter - South San Francisco CA, US
Charles Marlowe - Redwood City CA, US
Anjali Pandey - Fremont CA, US
John Mullins - San Francisco CA, US
Robert Scarborough - Half Moon Bay CA, US
Greg Butke - Mentor OH, US
Barry Jacobson - Ann Arbor MI, US
Derek Walker - Summit NJ, US

International Classification:

C07D335/06
C07D307/94

US Classification:

549/023000, 549/396000

Abstract:

Disclosed are processes for producing a (2S) or (2R) 4-oxo-chroman-2-yl acyl compounds and chroman-2-yl acyl compounds, esters or amides thereof as well as derivatives thereof. Such processes may involve chiral synthesis or achiral synthesis, preferably coupled with a resolution procedure. Such compounds, particularly (2S) or (2R) acetic acid esters, are useful intermedates for producing platelet aggregation inhibitors and/or are themselves potent platelet aggregation inhibitors. Further disclosed are processes for making derivatives of such substantially pure, or enhanced compositions of single (2R) or (2S) enantiomer intermediates or processes for producing final products or salts from such desired enantiomers.

US Patent:

57310360, Mar 24, 1998

Filed:

Jan 21, 1997

Appl. No.:

8/786823

Inventors:

Robert D. Battershell - Painesville OH
Barry M. Jacobson - Pepper Pike OH
Ann C. Abraham - South Euclid OH
Belinda M. Pereira - Mayfield Heights OH
J. Vern Kempf - Chardon OH

Assignee:

ISK Biosciences Corporation - Mentor OH

International Classification:

B05D 300
B05D 312
B05D 118

US Classification:

427297

Abstract:

A method is described for preserving wood comprising infiltrating the wood with gaseous carbon disulfide and impregnating the wood with an aqueous solution comprising a copper source, and dimethylamine.