Bart L Decorte

US Patent:

8513271, Aug 20, 2013

Filed:

Oct 28, 2010

Appl. No.:

12/913966

Inventors:

Steven J. Coats - McDonough GA, US
Haiyan Bian - Princeton NJ, US
Peter J. Connolly - New Providence NJ, US
Gilles Bignan - Bridgewater NJ, US
Chaozhong Cai - North Wales PA, US
Scott L. Dax - Landenberg PA, US
Bart L. DeCorte - Southampton PA, US
Shu-Chen Lin - Doylestown PA, US
Li Liu - Germantown MD, US
Mark J. Macielag - Branchburg NJ, US
Philip M. Pitis - North Wales PA, US
Yue-Mei Zhang - Belle Mead NJ, US
Bin Zhu - Hillsborough NJ, US
Wei He - Audubon PA, US

Assignee:

Janssen Pharmaceutica, NV

International Classification:

A01N 43/54

US Classification:

514269, 544319

Abstract:

Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows:.

US Patent:

20060287297, Dec 21, 2006

Filed:

Jun 15, 2006

Appl. No.:

11/424311

Inventors:

Bart DeCorte - Southampton PA, US
Li Liu - Doylestown PA, US
Mark McDonnell - Lansdale PA, US
Jim McNally - Souderton PA, US

International Classification:

A61K 31/55
A61K 31/506

US Classification:

514216000, 514304000, 514252040, 514255050, 514256000, 540593000, 544238000, 544295000, 544405000, 546126000

Abstract:

The invention is directed to compounds of Formula (I) useful as delta and mu opioid receptor modulators. Pharmaceutical and veterinary compositions and methods of treating mild to severe pain and various diseases using compounds of the invention are also described.

US Patent:

20090275610, Nov 5, 2009

Filed:

Jul 10, 2009

Appl. No.:

12/500706

Inventors:

Bart DeCorte - Southampton PA, US
Li Liu - Doylestown PA, US
Mark McDonnell - Lansdale PA, US
Jim McNally - Souderton PA, US

International Classification:

A61K 31/4725
C07D 405/14
A61K 31/403
A61K 31/4439
A61P 25/00

US Classification:

514310, 548454, 514414, 514339, 5462767, 546143

Abstract:

The invention is directed to compounds of Formula (I) useful as delta and mu opioid receptor modulators. Pharmaceutical and veterinary compositions and methods of treating mild to severe pain and various diseases using compounds of the invention are also described.

US Patent:

20110224209, Sep 15, 2011

Filed:

Mar 9, 2011

Appl. No.:

13/043609

Inventors:

Bart L. DeCorte - Southampton PA, US
Renee L. DesJarlais - Saint Davids PA, US
Yifang Huang - Lansdale PA, US
Michael H. Parker - Chalfont PA, US
Dennis J. Hlasta - Doylestown PA, US

International Classification:

A61K 31/4535
C07D 409/06
C07D 409/14
C07D 211/64
C07D 401/06
C07D 417/14
C07D 413/14
C07D 401/14
A61K 31/4545
A61K 31/451
A61K 31/454
A61K 31/445
A61K 31/5377
A61K 31/4725
A61K 31/506
A61P 29/00
A61P 11/06
A61P 11/00
A61P 1/00
A61P 9/00

US Classification:

5142355, 546213, 546194, 546210, 546226, 546209, 546187, 544130, 546208, 546146, 544335, 514326, 514318, 514330, 514316, 514307, 514256

Abstract:

The present invention is directed to 4,4-di-substituted piperidine derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by DPP-1.

US Patent:

20110269759, Nov 3, 2011

Filed:

Oct 28, 2010

Appl. No.:

12/913986

Inventors:

Steven J. COATS - McDonough GA, US
Haiyan BIAN - Princeton NJ, US
Chaozhong CAI - North Wales PA, US
Bart L. DECORTE - Southampton PA, US
Li LIU - Germantown MD, US
Mark J. MACIELAG - Branchburg NJ, US
Scott L. DAX - Landenberg PA, US
Philip M. PITIS - North Wales PA, US
Peter J. CONNOLLY - New Providence NJ, US
Wei HE - Audubon PA, US

International Classification:

A61K 31/5377
A61K 31/506
C07D 413/14
C07D 403/14
A61K 31/496
A61P 19/02
A61P 25/06
A61P 25/04
A61P 13/10
A61P 17/00
A61P 1/00
A61P 35/00
A61P 29/00
A61P 25/16
A61P 25/24
A61P 25/32
A61P 9/00
C07D 401/14

US Classification:

5142358, 544319, 514269, 544296, 544295, 51425218, 544123

Abstract:

Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows:wherein R, R, R, R, and Y are defined herein.

US Patent:

20120302541, Nov 29, 2012

Filed:

Oct 28, 2010

Appl. No.:

13/503433

Inventors:

Steven J. Coats - McDonough GA, US
Haiyan Bian - Princeton NJ, US
Chaozhong Cai - North Wales PA, US
Bart L. DeCorte - Southampton PA, US
Li Liu - Germantown MD, US
Mark J. Macielag - Gwynedd Valley PA, US
Scott L. Dax - Landenberg PA, US
Philip M. Pitis - North Wales PA, US
Peter J. Connolly - New Providence NJ, US
Wei He - Audubon PA, US

International Classification:

A61K 31/40
C07D 211/26
A61K 31/445
C07D 401/12
A61K 31/4439
C07D 405/12
A61K 31/4025
C07D 409/12
C07D 403/12
A61K 31/506
C07D 295/096
A61K 31/495
C07D 413/12
A61K 31/4245
C07D 451/02
A61K 31/46
C07C 217/84
A61K 31/136
C07D 205/04
A61K 31/397
C07D 453/02
A61K 31/439
A61P 29/00
A61P 19/02
A61P 25/06
A61P 11/02
A61P 13/10
A61P 17/00
A61P 11/12
A61P 25/00
A61P 25/02
A61P 1/00
A61P 35/00
A61P 25/24
A61P 25/16
A61P 25/30
A61P 25/32
A61P 13/00
A61P 15/00
A61P 1/12
A61P 9/00
A61P 11/00
C07D 207/14

US Classification:

5142102, 548557, 514408, 546232, 514331, 5462764, 514343, 548517, 514422, 548527, 544333, 514256, 544395, 51425503, 548131, 514364, 546124, 514304, 564443, 514646, 548950, 51421001, 546133, 514305, 564431

Abstract:

Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows:wherein R, R, R, R, and Y are defined herein.

US Patent:

20130310358, Nov 21, 2013

Filed:

Jul 25, 2013

Appl. No.:

13/950952

Inventors:

- Beerse, BE
Haiyan Bian - Princeton NJ, US
Peter J. Connolly - New Providence NJ, US
Giles Bignan - Bridgewater NJ, US
Chaozhong Cai - North Wales PA, US
Scott L. Dax - Landenberg PA, US
Bart L. DeCorte - Southampton PA, US
Shu-Chen Lin - Doylestown PA, US
Li Liu - Germantown MD, US
Mark J. Macielag - Gwynedd Valley PA, US
Philip M. Pitis - North Wales PA, US
Yue-Mei Zhang - Belle Mead NJ, US
Bin Zhu - Newtown PA, US
Wei He - Audubon PA, US

Assignee:

Janssen Pharmaceutica, NV - Beerse

International Classification:

C07D 239/47
C07D 413/14
C07D 403/14
C07D 403/04
C07D 401/04
C07D 409/14
C07D 405/14
C07D 417/14
C07D 401/14
C07D 401/12

US Classification:

5142102, 514269, 514274, 51425218, 514249, 5142358, 51425505, 51425214, 514218

Abstract:

Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows:wherein R, R, R, and L, A, and Rare defined herein.

US Patent:

20190031618, Jan 31, 2019

Filed:

Oct 3, 2018

Appl. No.:

16/150484

Inventors:

- Beerse, BE
Rui Zhang - Belle Mead NJ, US
Yue-Mei Zhang - Wellesley MA, US
Bin Zhu - Newtown PA, US
Michael H. Parker - Chalfont PA, US
Donald W. Ludovici - Quakertown PA, US
Daniel J. Parks - Downington PA, US
Bart L. DeCorte - Southampton PA, US
Michael N. Greco - Lansdale PA, US

Assignee:

Janssen Pharmaceutica NV - Beerse

International Classification:

C07D 235/18
C07D 401/14
C07D 405/04
C07D 409/14
C07D 401/06
C07D 401/04
C07C 53/18
C07D 417/14
C07D 409/10
C07D 403/04
C07D 405/06
C07D 471/08
C07D 417/06
C07D 405/14

Abstract:

The present invention is directed to benzimidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions mediated by the CB-1 receptor, more particularly, use in the treatment of disorders and conditions responsive to inverse agonism of the CB-1 receptor. More particularly, the compounds of the present invention are useful in the treatment of metabolic disorders.