Ben H Wu

US Patent:

7531355, May 12, 2009

Filed:

Jul 29, 2005

Appl. No.:

11/192753

Inventors:

Larissa V. Rodríguez - Los Angeles CA, US
Ben Wu - Los Angeles CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

C12N 5/00

US Classification:

435377, 435325, 435375

Abstract:

This invention also provides a purified or isolated population of ADSCs that can differentiate into a cell of the leiomyogenic lineage, e. g. , smooth muscle or skeletal muscle. In yet another aspect, the population additionally can be differentiated into a lineage selected from the group consisting of osteogenic, adipogenic, chondrogenic, myogenic and neuronal. This invention further provides a composition comprising a substantially homogeneous expanded population of smooth muscle cells. This invention provides a composition comprising a substantially homogeneous expanded population of skeletal muscle cells. Also provided herein is an isolated composition comprising a purified adipose-derived stem cell (ADSC) or progeny of said ADSC and an effective amount of laminin or heparin, effective to induce leiomyogenic differentiation. Diagnositic and therapeutic uses for these compositions are provided herein.

US Patent:

7544486, Jun 9, 2009

Filed:

Feb 9, 2004

Appl. No.:

10/544553

Inventors:

Kang Ting - Beverly Hills CA, US
Shunichi Kuroda - Osaka, JP
Ben Wu - Los Angeles CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

C12N 5/10
C12N 1/21
C12N 15/63
C12N 15/12

US Classification:

435 691, 436 697, 436325, 436365, 4362523, 536 231, 536 235, 536 241

Abstract:

The invention generally relates to a bone growth factor, and more particularly to compositions including NELL1, articles of manufacture including NELL1 and methods of using NELL1 to induce bone formation. This invention also provides methods for the expression and purification of NELL1 and NELL2 peptides.

US Patent:

7687462, Mar 30, 2010

Filed:

Nov 7, 2006

Appl. No.:

11/594510

Inventors:

Kang Ting - Beverly Hills CA, US
Ben Wu - Los Angeles CA, US
Chia Soo - Beverly Hills CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A61K 38/00
A61K 38/16
A61K 38/17
A61K 38/18
A61K 31/7088
A61K 31/7105
A61K 31/711
A61K 31/713

US Classification:

514 12, 514 2, 514 7, 514 8, 514 44

Abstract:

Provided herein is a composition for cartilage formation or regeneration comprising a NELL gene product and a method of treating cartilage-related conditions using such a composition.

US Patent:

7691607, Apr 6, 2010

Filed:

Nov 17, 2006

Appl. No.:

11/601529

Inventors:

Kang Ting - Beverly Hills CA, US
Shunichi Kuroda - Osaka, JP
Ben Wu - Los Angeles CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

C12N 15/06
C12N 15/07
C12N 15/12
C12N 15/19
C12N 15/63
C12N 15/85

US Classification:

435 691, 4353201, 435 698, 435325, 435350, 435351, 435352, 435353, 435354, 435358, 435360, 435363, 435366, 536 231, 536 235, 536 241

Abstract:

Methods of preparing a NELL peptide are disclosed.

US Patent:

7807787, Oct 5, 2010

Filed:

Mar 9, 2009

Appl. No.:

12/400714

Inventors:

Kang Ting - Beverly Hills CA, US
Shunichi Kuroda - Osaka, JP
Ben Wu - Los Angeles CA, US

Assignee:

The Regents of The University of California - Oakland CA

International Classification:

C07K 14/00
C07K 14/435
C07K 14/46
C07K 14/47
C07K 14/475

US Classification:

530350, 435 691, 435 697, 435 698, 536 231, 536 234, 536 235, 536 241

Abstract:

The invention generally relates to a bone growth factor, and more particularly to compositions including NELL1, articles of manufacture including NELL1 and methods of using NELL1 to induce bone formation. This invention also provides methods for the expression and purification of NELL1 and NELL2 peptides.

US Patent:

7833968, Nov 16, 2010

Filed:

Feb 16, 2006

Appl. No.:

11/884525

Inventors:

Chia Soo - Beverly Hills CA, US
Kang Ting - Beverly Hills CA, US
Shunichi Kuroda - Osaka, JP
Ben Wu - Los Angeles CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

C07K 14/00

US Classification:

514 2, 530350

Abstract:

Provided in the present application is a pharmaceutical composition for treating, preventing, or ameliorating a bone or cartilage condition and methods of making and using the same.

US Patent:

8048646, Nov 1, 2011

Filed:

Mar 9, 2009

Appl. No.:

12/400715

Inventors:

Kang Ting - Beverly Hills CA, US
Shunichi Kuroda - Osaka, JP
Ben Wu - Los Angeles CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

C12N 15/11
C12N 15/12
C12N 15/63
C12N 15/79
C12N 15/85
C12N 15/866
C12N 5/07
C12N 5/10
C12N 5/16
C12N 1/21
C07K 14/00
C07K 14/435

US Classification:

435 691, 435 698, 435348, 4352523, 435325, 4353201, 536 231, 536 235, 536 241, 530350

Abstract:

The invention generally relates to a bone growth factor, and more particularly to compositions including NELL1, articles of manufacture including NELL1 and methods of using NELL1 to induce bone formation. This invention also provides methods for the expression and purification of NELL1 and NELL2 peptides.

US Patent:

8053412, Nov 8, 2011

Filed:

Feb 4, 2010

Appl. No.:

12/700630

Inventors:

Kang Ting - Beverly Hills CA, US
Shunichi Kuroda - Osaka, JP
Ben Wu - Los Angeles CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A61K 38/16
A61K 38/17
A61K 38/18

US Classification:

514 167, 514 168, 514 169, 514 171, 514 212, 514 76, 514 81, 514 82, 514 85, 514 86, 514 88, 514 89, 514 97, 514 118

Abstract:

Recombinant NELL peptides and methods of preparing the same are disclosed.