Niclas E Bengtsson from Poulsbo, WA, age 46

Multimodal Nanoparticles For Non-Invasive Bio-Imaging
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US Patent:

8617522, Dec 31, 2013
Filed:

Dec 28, 2012
Appl. No.:

13/729815
Inventors:

Brij M. Moudgil - Gainesville FL, US
Glenn A. Walter - Newberry FL, US
Stephen R. Grobmyer - Shaker Heights OH, US
Swadeshmukul Santra - Orlando FL, US
Huabei Jiang - Gainesville FL, US
Scott Chang Brown - Hockessin DE, US
Edward W. Scott - Gainesville FL, US
Qizhi Zhang - Gainesville FL, US
Niclas Bengtsson - Lake Forest Park WA, US
Assignee:

University of Florida Research Foundation, Inc. - Gainesville FL
International Classification:

A61K 49/04
A61K 49/00
A61B 5/055
A61N 5/00
US Classification:

424 942, 424 92, 424 932, 424 96, 600411, 600431
Abstract:

Multimodal nanoparticles are nanoparticles containing contrast agents for PAT and one or more of luminescence imaging, x-ray imaging, and/or MRI. The multimodal nanoparticles can have a dielectric core comprising an oxide with a metal coating on the core. The particles can be metal speckled. The multimodal nanoparticles can be used for therapeutic purposes such as ablation of tumors or by neutron capture in addition to use as contrast agents for imaging.

Multimodal Nanoparticles For Non-Invasive Bio-Imaging
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US Patent:

20100254911, Oct 7, 2010
Filed:

Aug 28, 2008
Appl. No.:

12/675633
Inventors:

Parvesh Sharma - Gainesville FL, US
Brij M. Moudgil - Gainesville FL, US
Glenn A. Walter - Newberry FL, US
Stephen R. Grobmyer - Gainesville FL, US
Swadeshmukul Santra - Orlando FL, US
Huabei Jiang - Gainesville FL, US
Scott Chang Brown - Gainesville FL, US
Edward W. Scott - Gainesville FL, US
Qizhi Zhang - Gainesville FL, US
Niclas Bengtsson - Gainesville FL, US
Assignee:

UNIVERSITY OF FLORIDA RESEARCH FOUNDATION INC. - Gainesville FL
International Classification:

A61K 49/06
A61K 49/04
US Classification:

424 932, 424 942
Abstract:

Multimodal nanoparticles are nanoparticles containing contrast agents for PAT and one or more of luminescence imaging, x-ray imaging, and/or MRI. The multimodal nanoparticles can have a dielectric core comprising an oxide with a metal coating on the core. The particles can be metal speckled. The multimodal nanoparticles can be used for therapeutic purposes such as ablation of tumors or by neutron capture in addition to use as contrast agents for imaging.

Near-Ir Indocyanine Green Doped Multimodal Silica Nanoparticles And Methods For Making The Same
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US Patent:

20130108552, May 2, 2013
Filed:

Feb 24, 2011
Appl. No.:

13/582226
Inventors:

Parvesh Sharma - Gainesville FL, US
Scott Chang Brown - Hockessin DE, US
Niclas Bengtsson - Lake Forest Park WA, US
Glenn A. Walter - Newberry FL, US
Nobutaka Iwakuma - Kurume, JP
Edward W. Scott - Gainesville FL, US
Stephen R. Grobmyer - Gainesville FL, US
Swadeshmukul Santra - Orlando FL, US
Brij M. Moudgil - Gainesville FL, US
Assignee:

UNIVERSITY OF FLORIDA RESEARCH FOUNDATION INC. - GAINESVILLE FL
International Classification:

A61N 5/06
A61K 49/00
G01N 21/64
US Classification:

424 932, 436172, 424 96, 424490, 424 93, 604 20
Abstract:

The subject invention provides novel fluorescent core-shell nanoparticles comprising an encapsulated fluorescent core comprising an ionically bound fluorescent dye and a metal oxide shell. In one exemplary embodiment of the invention a core containing indocyanine green (ICG) with a silica shell that displays excellent photostability for generation of a near infrared fluorescence signal. The fluorescent core-shell nanoparticle can be further modified to act as an MRI, x-ray, or PAT contrast agent. The ICG nanoparticles can also be used as photodynamic therapeutic agent. Other embodiments of the invention directed to methods of making the novel core-shell nanoparticles and to the use of the core-shell nanoparticles for in vitro or in vivo imaging.

Muscle-Specific Crispr/Cas9 Editing Of Genes
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US Patent:

20170362635, Dec 21, 2017
Filed:

Jun 20, 2017
Appl. No.:

15/628533
Inventors:

- Seattle WA, US
Niclas Bengtsson - Seattle WA, US
Stephen D. Hauschka - Seattle WA, US
Assignee:

University of Washington - Seattle WA
International Classification:

C12Q 1/68
C07H 21/02
C12N 15/11
C12N 15/63
C12N 9/22
C07H 21/04
A61K 38/43
C12N 15/10
C12N 15/00
C12N 2310/20
Abstract:

Pharmaceutical compositions including a muscle-specific nuclease cassette, one or more guide RNA cassettes, and a delivery system for delivery of the muscle-specific nuclease cassette and the one or more gRNA cassettes are provided. The pharmaceutical composition may also include a mutation-corrected DNA template including a modification to be made in a target nucleic acid sequence. Methods for treating a subject having a muscular or neuromuscular disorder are also provided. The methods may include administering to the subject a therapeutically effective amount of the pharmaceutical composition. Methods of modifying or editing the sequence of a target nucleic acid sequence in a muscle cell are also provided. The methods may include contacting or transducing the muscle cell with a muscle-specific nuclease cassette and one or more gRNA cassettes.