Benjamin S Bowen

US Patent:

6541684, Apr 1, 2003

Filed:

Feb 9, 1999

Appl. No.:

09/246963

Inventors:

Benjamin A. Bowen - Hayward CA
Mark A. Chamberlin - Windsor Heights IA
Bruce J. Drummond - Des Moines IA
John A. McElver - Durham NC
Rodney J. Rothstein - Maplewood NJ

Assignee:

Trustees of Columbia University in the City of New York - New York NY
Pioneer Hi-Bred International, Inc. - Johnston IA

International Classification:

A01H 500

US Classification:

8003201, 435 691, 435196, 536 231, 536 235, 536 241

Abstract:

Nucleic acid sequences encoding two RAD51 recombinases active in maize plants are provided. cDNA sequences including the ZmRAD51 coding sequences and unique 3â-untranslated regions which are useful as RFLP probes, are also provided. The production of plasmids containing a nucleic acid sequence encoding a ZmRAD51 fusion protein, as well as the use of the plasmids to introduce the ZmRAD51 coding sequence into a host cell, such as maize cell, are also disclosed.

US Patent:

6905857, Jun 14, 2005

Filed:

Sep 18, 2002

Appl. No.:

10/246581

Inventors:

Benjamin A. Bowen - Berkeley CA, US
Mark A. Chamberlin - Windsor Heights IA, US
Bruce J. Drummond - West Salem WI, US
John A. McElver - Durham NC, US
Rodney J. Rothstein - Maplewood NJ, US

Assignee:

Pioneer Hi-Bred International, Inc. - Johnston IA
Trustees of Columbia University in the City of New York - New York NY

International Classification:

C12N009/12

US Classification:

435194, 435424, 800298, 8003201

Abstract:

Nucleic acid sequences encoding two RAD51 recombinases active in maize plants are provided. cDNA sequences including the ZmRAD51 coding sequences and unique 3′-untranslated regions which are useful as RFLP probes, are also provided. The production of plasmids containing a nucleic acid sequence encoding a ZmRAD51 fusion protein, as well as the use of the plasmids to introduce the ZmRAD51 coding sequence into a host cell, such as maize cell, are also disclosed.

US Patent:

20030166026, Sep 4, 2003

Filed:

Jan 8, 2003

Appl. No.:

10/339782

Inventors:

Laurie Goodman - El Granada CA, US
Benjamin Bowen - Berkeley CA, US

Assignee:

Lynx Therapeutics, Inc. - Hayward CA

International Classification:

C12Q001/68
G01N033/574
C07H021/04
C12N009/00
C12P021/02
C12N005/06

US Classification:

435/007230, 435/069300, 435/183000, 435/320100, 435/325000, 435/006000, 536/023200

Abstract:

Nucleic acids, proteins, antibodies, marker sets and arrays are provided for biomarkers for breast cancer. Methods for detecting breast cancer, modulating breast cancer phenotypes in cells, and for treating a subject with breast cancer are also provided.

US Patent:

20030170700, Sep 11, 2003

Filed:

Jan 8, 2003

Appl. No.:

10/340192

Inventors:

Jin Shang - Fremont CA, US
Benjamin Bowen - Berkeley CA, US

Assignee:

Lynx Therapeutics, Inc.

International Classification:

C12Q001/68
A01K067/00
G06F019/00
G01N033/48
G01N033/50
C07H021/04
A61K048/00
C12N009/02

US Classification:

435/006000, 435/069100, 435/189000, 435/320100, 435/325000, 514/044000, 536/023200, 702/020000, 800/008000

Abstract:

Polynucleotides, proteins, antibodies, labeled probes, marker sets, and arrays related to secreted and cell surface proteins that are altered in response to cholesterol are provided. Methods of detecting alterations in secreted and cell surface proteins in response to alterations in cholesterol levels (exposure), modulating cholesterol phenotype in cells and for treating a subject with adverse effects of altered levels of cholesterol, e.g., elevated or high levels of cholesterol, are also provided.

US Patent:

20030175678, Sep 18, 2003

Filed:

Jan 24, 2002

Appl. No.:

10/056479

Inventors:

Benjamin Bowen - Berkeley CA, US
Edward Deakin - Sheffield, GB
Neil Goldsmith - Oxford, GB
Christian Haudenschild - Oakland CA, US
David Houck - Chapel Hill NC, US
James McAlpine - Bolton MA, US
Soren Nielsen - Allerod, DK
Christopher Pazoles - Westboro MA, US
Margaret Spencer - Sheffield, GB
Angela Stafford - Castleton, GB

International Classification:

A01H001/00
C12Q001/00
C12P017/08
C12P007/02
C12N015/82
C12N005/04

US Classification:

435/004000, 435/419000, 435/124000, 800/278000, 435/155000

Abstract:

The invention features a method for identifying a gene associated with a desired phenotype. This method includes the steps of: (a) providing a plurality of cell cultures that include plant, animal, or fungal cells capable of exhibiting a desired phenotype; (b) contacting each of at least a subset of said cells with a stimulus that (i) induces said cells to exhibit the phenotype, or (ii) does not induce said cell cultures to exhibit the phenotype; (c) determining the presence of the phenotype in the cell cultures of step (b); and (d) identifying a gene having increased expression in response to stimuli that induce the phenotype but do not have increased expression in response to stimuli that do not induce the phenotype.

US Patent:

20030180764, Sep 25, 2003

Filed:

Jan 8, 2003

Appl. No.:

10/339793

Inventors:

Jin Shang - Fremont CA, US
Benjamin Bowen - Berkeley CA, US

Assignee:

Lynx Therapeutics, Inc.

International Classification:

C12Q001/68
G01N033/53
G06F019/00
G01N033/48
G01N033/50
C07H021/04

US Classification:

435/006000, 435/007100, 702/019000, 702/020000, 536/023200

Abstract:

Genes, nucleic acids, proteins, antibodies, marker sets, and arrays are provided. Methods of detecting conditions associated with elevated cholesterol and lipid, as well as during adipogenesis, are also provided.

US Patent:

20030188343, Oct 2, 2003

Filed:

Jan 7, 2003

Appl. No.:

10/338777

Inventors:

Benjamin Bowen - Berkeley CA, US
Christian Haudenschild - Oakland CA, US
Edward Buckler - Raleigh NC, US

Assignee:

Lynx Therapeutics, Inc. - Hayward CA

International Classification:

A01H001/00
C12N005/04
C12Q001/68
C07H021/04
C12N015/82

US Classification:

800/287000, 435/006000, 435/419000, 435/468000, 536/023600

Abstract:

Genes, nucleic acids and polypeptides associated with growth traits in plants are provided. Related probes, antibodies, marker sets, and arrays are provided as well as methods for predicting plant growth traits.

US Patent:

20040133941, Jul 8, 2004

Filed:

Feb 23, 2004

Appl. No.:

10/785744

Inventors:

Benjamin Bowen - Berkeley CA, US
Edward Deakin - Sheffield, GB
Neil Goldsmith - Oxford, GB
Christian Haudenschild - Oakland CA, US
David Houck - Chapel Hill NC, US
James McAlpine - Bolton MA, US
Soren Nielsen - Allerod, DK
Christopher Pazoles - Westboro MA, US
Margaret Spencer - Sheffield, GB
Angela Stafford - Castleton, GB

International Classification:

A01H001/00
C12N015/82
C12Q001/68

US Classification:

800/278000, 435/006000

Abstract:

The invention features a method for identifying a gene associated with a desired phenotype. This method includes the steps of: (a) providing a plurality of cell cultures that include plant, animal, or fungal cells capable of exhibiting a desired phenotype; (b) contacting each of at least a subset of said cells with a stimulus that (i) induces said cells to exhibit the phenotype, or (ii) does not induce said cell cultures to exhibit the phenotype; (c) determining the presence of the phenotype in the cell cultures of step (b); and (d) identifying a gene having increased expression in response to stimuli that induce the phenotype but do not have increased expression in response to stimuli that do not induce the phenotype.