Benjamin P Bowen

US Patent:

6541684, Apr 1, 2003

Filed:

Feb 9, 1999

Appl. No.:

09/246963

Inventors:

Benjamin A. Bowen - Hayward CA
Mark A. Chamberlin - Windsor Heights IA
Bruce J. Drummond - Des Moines IA
John A. McElver - Durham NC
Rodney J. Rothstein - Maplewood NJ

Assignee:

Trustees of Columbia University in the City of New York - New York NY
Pioneer Hi-Bred International, Inc. - Johnston IA

International Classification:

A01H 500

US Classification:

8003201, 435 691, 435196, 536 231, 536 235, 536 241

Abstract:

Nucleic acid sequences encoding two RAD51 recombinases active in maize plants are provided. cDNA sequences including the ZmRAD51 coding sequences and unique 3â-untranslated regions which are useful as RFLP probes, are also provided. The production of plasmids containing a nucleic acid sequence encoding a ZmRAD51 fusion protein, as well as the use of the plasmids to introduce the ZmRAD51 coding sequence into a host cell, such as maize cell, are also disclosed.

US Patent:

6905857, Jun 14, 2005

Filed:

Sep 18, 2002

Appl. No.:

10/246581

Inventors:

Benjamin A. Bowen - Berkeley CA, US
Mark A. Chamberlin - Windsor Heights IA, US
Bruce J. Drummond - West Salem WI, US
John A. McElver - Durham NC, US
Rodney J. Rothstein - Maplewood NJ, US

Assignee:

Pioneer Hi-Bred International, Inc. - Johnston IA
Trustees of Columbia University in the City of New York - New York NY

International Classification:

C12N009/12

US Classification:

435194, 435424, 800298, 8003201

Abstract:

Nucleic acid sequences encoding two RAD51 recombinases active in maize plants are provided. cDNA sequences including the ZmRAD51 coding sequences and unique 3′-untranslated regions which are useful as RFLP probes, are also provided. The production of plasmids containing a nucleic acid sequence encoding a ZmRAD51 fusion protein, as well as the use of the plasmids to introduce the ZmRAD51 coding sequence into a host cell, such as maize cell, are also disclosed.

US Patent:

7144486, Dec 5, 2006

Filed:

Dec 12, 2001

Appl. No.:

10/020776

Inventors:

Ingrid Fritsch - Fayetteville AR, US
Charles Sherman Henry - Mississippi State MS, US
Benjamin P. Bowen - Tempe AZ, US
Walter R. Vandaveer - Lawrence KS, US
Nicole Bratcher - Pittsburg OK, US

Assignee:

Board of Trustees of the University of Arkansas - Little Rock AR

International Classification:

G01N 27/31
G01N 27/327
G01N 27/333

US Classification:

20440306, 2044031, 204418, 204400

Abstract:

Microcavities and micropores that are microscopic (

US Patent:

7169272, Jan 30, 2007

Filed:

Mar 22, 2002

Appl. No.:

10/104756

Inventors:

Ingrid Fritsch - Fayetteville AR, US
Charles Sherman Henry - Starkville MS, US
Benjamin P. Bowen - Tempe AZ, US
Walter Vandaveer - Lawrence KS, US
Nicole Bratcher - Pittsburg OK, US

Assignee:

Board of Trustees of the University of Arkansas - Little Rock AR

International Classification:

G01N 27/327
C12N 11/00

US Classification:

20440301, 20440307, 435174

Abstract:

Construction and characterization of microfabricated recessed disk microelectrodes (RDMs) of 14 and 55 μm diameter are reported. The work reported here makes several new contributions to the current literature on microfabricated RDMs. Hybrid blamers were constructed by fusion of vesicles of dimyristoylphosphatidyl choline (DMPC), which forms the top layer, with ethanol-rinsed SAMs of hexadecanethiol on gold, which form the bottom layer. Gramicidin A was included in the modifying solutions to incorporate it into hybrid blamers.

US Patent:

7193706, Mar 20, 2007

Filed:

Aug 2, 2001

Appl. No.:

10/343412

Inventors:

Neal W. T. Woodbury - Tempe AZ, US
Benjamin P. Bowen - Tempe AZ, US
Allan Scruggs - Tempe AZ, US

Assignee:

Arizona Board of Regents, Acting on Behalf of Arizona State University - Tempe AZ

International Classification:

G01J 3/30

US Classification:

356317, 356210, 435 402, 435 855, 4351731, 4351734, 514183, 514 31, 522 25, 522 26

Abstract:

This invention provides a method for screening large numbers of individual cells or colonies of cells using scanning microscopy coupled with fluorescence lifetime measurement and analysis, using time-correlated single photon counting. This invention further provides an automated method for selecting cells that exhibit desired characteristics. The method uses the scanning microscope system to focus a laser beam onto a surface upon which cells are immobilized on the timescale of the procedure. The cells that are illuminated in this way are killed or their growth is inhibited. The focused laser beam is scanned across the surface and turned on and off during the scanning process such that only non-irradiated cells survive, resulting in a patterned cell growth This invention further provides a computer-controlled projection device, such as a micro-mirror array or a liquid crystal display system, which is sued to project an image onto the cells.

US Patent:

20030170700, Sep 11, 2003

Filed:

Jan 8, 2003

Appl. No.:

10/340192

Inventors:

Jin Shang - Fremont CA, US
Benjamin Bowen - Berkeley CA, US

Assignee:

Lynx Therapeutics, Inc.

International Classification:

C12Q001/68
A01K067/00
G06F019/00
G01N033/48
G01N033/50
C07H021/04
A61K048/00
C12N009/02

US Classification:

435/006000, 435/069100, 435/189000, 435/320100, 435/325000, 514/044000, 536/023200, 702/020000, 800/008000

Abstract:

Polynucleotides, proteins, antibodies, labeled probes, marker sets, and arrays related to secreted and cell surface proteins that are altered in response to cholesterol are provided. Methods of detecting alterations in secreted and cell surface proteins in response to alterations in cholesterol levels (exposure), modulating cholesterol phenotype in cells and for treating a subject with adverse effects of altered levels of cholesterol, e.g., elevated or high levels of cholesterol, are also provided.

US Patent:

20030175678, Sep 18, 2003

Filed:

Jan 24, 2002

Appl. No.:

10/056479

Inventors:

Benjamin Bowen - Berkeley CA, US
Edward Deakin - Sheffield, GB
Neil Goldsmith - Oxford, GB
Christian Haudenschild - Oakland CA, US
David Houck - Chapel Hill NC, US
James McAlpine - Bolton MA, US
Soren Nielsen - Allerod, DK
Christopher Pazoles - Westboro MA, US
Margaret Spencer - Sheffield, GB
Angela Stafford - Castleton, GB

International Classification:

A01H001/00
C12Q001/00
C12P017/08
C12P007/02
C12N015/82
C12N005/04

US Classification:

435/004000, 435/419000, 435/124000, 800/278000, 435/155000

Abstract:

The invention features a method for identifying a gene associated with a desired phenotype. This method includes the steps of: (a) providing a plurality of cell cultures that include plant, animal, or fungal cells capable of exhibiting a desired phenotype; (b) contacting each of at least a subset of said cells with a stimulus that (i) induces said cells to exhibit the phenotype, or (ii) does not induce said cell cultures to exhibit the phenotype; (c) determining the presence of the phenotype in the cell cultures of step (b); and (d) identifying a gene having increased expression in response to stimuli that induce the phenotype but do not have increased expression in response to stimuli that do not induce the phenotype.

US Patent:

20030180764, Sep 25, 2003

Filed:

Jan 8, 2003

Appl. No.:

10/339793

Inventors:

Jin Shang - Fremont CA, US
Benjamin Bowen - Berkeley CA, US

Assignee:

Lynx Therapeutics, Inc.

International Classification:

C12Q001/68
G01N033/53
G06F019/00
G01N033/48
G01N033/50
C07H021/04

US Classification:

435/006000, 435/007100, 702/019000, 702/020000, 536/023200

Abstract:

Genes, nucleic acids, proteins, antibodies, marker sets, and arrays are provided. Methods of detecting conditions associated with elevated cholesterol and lipid, as well as during adipogenesis, are also provided.