Benjamin C Fisher

US Patent:

8389533, Mar 5, 2013

Filed:

Apr 6, 2009

Appl. No.:

12/936725

Inventors:

Richard V. Connors - Pacifica CA, US
Kang Dai - Albany CA, US
John Eksterowicz - San Francisco CA, US
Pingchen Fan - Fremont CA, US
Benjamin Fisher - San Mateo CA, US
Jiasheng Fu - Foster City CA, US
Kexue Li - Mountain View CA, US
Zhihong Li - Millbrae CA, US
Lawrence R. McGee - Pacifica CA, US
Rajiv Sharma - Mumbai, IN
Xiaodong Wang - Millbrae CA, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

A01N 43/54
A61K 31/505
C07D 237/00
C07D 239/00
C07D 241/00

US Classification:

514267, 544230

Abstract:

Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of CDK4-mediated disorders, such as cancer. The subject compounds are gem-disubstituted or spirocyclic pyridine, pyrimidine and triazine derivatives.

US Patent:

20110086834, Apr 14, 2011

Filed:

Jun 26, 2009

Appl. No.:

12/997868

Inventors:

Guoqing Chen - Palo Alto CA, US
Timothy D. Cushing - Pacifica CA, US
Paul Faulder - Cheshire, GB
Benjamin Fisher - San Mateo CA, US
Xiao He - Foster City CA, US
Kexue Li - Mountain View CA, US
Zhihong Li - Millbrae CA, US
Wen Liu - Foster City CA, US
Lawrence R. Mcgee - Pacifica CA, US
Vatee Pattaropong - Burlingame CA, US
Jennifer L. Seganish - Scotch Plains NJ, US
Youngshook Shin - Emeryville CA, US
Zhulun Wang - Palo Alto CA, US

Assignee:

AMGEN INC. - Thousand Oaks CA

International Classification:

A61K 31/506
C07D 413/14
C07D 403/14
C07D 401/14
C07D 417/14
C07D 413/04
C07D 403/04
C07D 409/14
C07D 491/107
C07D 498/10
C07D 473/16
C07D 487/04
C07D 407/14
C07D 239/48
C07D 471/10
C07D 495/10
C07D 487/14
A61K 31/497
A61K 31/433
A61K 31/53
A61K 31/4439
A61K 31/427
A61K 31/52
A61K 31/5377
A61K 31/505
A61K 31/519
A61K 31/55
A61P 35/00
A61P 35/02
A61P 37/06
A61P 11/06
A61P 17/00
A61P 19/02
A61P 25/28
A61P 11/00
A61P 1/00
A61P 29/00

US Classification:

51421016, 544324, 544295, 548128, 544405, 544209, 544230, 544 71, 544212, 5462697, 544277, 548181, 544333, 544122, 544331, 544323, 544247, 540521, 544131, 544328, 514275, 51425505, 514361, 514245, 514256, 5142305, 514339, 514365, 5142632, 5142352, 514257, 51421206, 5142372

Abstract:

Selected compounds are effective for prophylaxis and treatment of inflammation and inflammatory disorders, such as NIK-mediated disorders. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, inflammation and the like.

US Patent:

20110142796, Jun 16, 2011

Filed:

Dec 18, 2008

Appl. No.:

12/808621

Inventors:

Richard V. Connors - Pacifica CA, US
Kang Dai - Albany CA, US
John Eksterowicz - San Francisco CA, US
Pingchen Fan - Fremont CA, US
Benjamin Fisher - San Mateo CA, US
Jiasheng Fu - Foster City CA, US
Kexue Li - Mountain View CA, US
Zhihong Li - Millbrae CA, US
Lawrence R. Mcgee - Pacifica CA, US
Rajiv Sharma - Mumbai, IN
Xiaodong Wang - Millbrae CA, US
Dustin L. Mcminn - Pacifica CA, US
Jeffrey T. Mihalic - San Francisco CA, US
Jeffrey Deignan - San Francisco CA, US

Assignee:

Amgen Inc - Thousand Oaks CA

International Classification:

A61K 31/519
C07D 471/14
C07D 487/04
A61K 31/551
C07D 487/14
A61K 31/5377
C07D 513/14
A61K 31/496
C07D 498/10
A61K 31/5386
A61P 35/00
A61P 35/04
A61K 38/21

US Classification:

424 854, 544251, 51425216, 544238, 51425202, 514267, 544250, 540575, 514218, 51425211, 544115, 5142328, 51425505, 544234, 514248, 544230, 544361, 51425303, 544231, 514249, 544105, 5142305, 51421021

Abstract:

Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of CDK4-mediated disorders, such as cancer. The subject compounds are fused pyridine, pyrimide and triazine derivatives.

US Patent:

20130085131, Apr 4, 2013

Filed:

Jun 30, 2011

Appl. No.:

13/702368

Inventors:

Minna Bui - Oakland CA, US
Benjamin Fisher - San Mateo CA, US
Xiaolin Hao - Foster City CA, US
Brian Lucas - San Francisco CA, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

C07D 413/14
C07D 401/14
C07D 401/12

US Classification:

51421018, 544328, 514256, 544122, 5142352, 544295, 51425218

Abstract:

Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with pi 110δ activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.

US Patent:

20140011796, Jan 9, 2014

Filed:

Sep 12, 2013

Appl. No.:

14/025688

Inventors:

Ana Gonzalez Buenrostro - San Mateo CA, US
Hilary Plake Beck - San Carlos CA, US
Xiaoqi Chen - Palo Alto CA, US
Richard Victor Connors - Pacifica CA, US
Jeffrey Deignan - San Francisco CA, US
Jason Duquette - Millbrae CA, US
John Eksterwicz - San Francisco CA, US
Benjamin Fisher - San Mateo CA, US
Brian Matthew Fox - Brisbane CA, US
Jiasheng Fu - Foster City CA, US
Zice Fu - Foster City CA, US
Felix Gonzalez Lopez De Turiso - San Mateo CA, US
Michael William Gribble - San Francisco CA, US
Dann James Gustin - Half Moon Bay CA, US
Julie Anne Heath - Orinda CA, US
Xin Huang - Wellesley MA, US
Xianyun Jiao - Belmont WA, US
Michael Johnson - San Francisco CA, US
Frank Kayser - San Francisco CA, US
David John Kopecky - San Francisco CA, US
Sujen Lai - Burlingame CA, US
Yihong Li - Millbrae CA, US
Zhihong Li - Millbrae CA, US
Jiwen Liu - Foster City CA, US
Jonathan Dante Low - Tarzana CA, US
Brian Stuart Lucas - San Francisco CA, US
Zhihua Ma - Foster City CA, US
Lawrence R. McGee - Pacifica CA, US
Joel McIntosh - Pacifica CA, US
Dustin McMinn - Pacifica CA, US
Julio Cesar Medina - San Carlos CA, US
Jeffrey Thomas Mihalic - San Francisco CA, US
Steven Howard Olson - Millbrae CA, US
Yosup Rew - Foster City CA, US
Philip Marley Roveto - San Francisco CA, US
Daqing Sun - Foster City CA, US
Xiaodong Wang - Millbrae CA, US
Yingcai Wang - Millbrae CA, US
Xuelei Yan - Foster City CA, US
Ming Yu - Foster City CA, US
Jiang Zhu - Palo Alto CA, US

Assignee:

AMGEN INC. - Thousand Oaks CA

International Classification:

C07D 211/76
C07D 417/12
C07D 413/06
C07D 471/10
C07D 409/04
C07D 401/04
C07D 279/02
C07D 491/08
C07D 498/08
C07D 417/14
C07D 491/153
C07D 417/06
C07D 401/06
C07D 405/04

US Classification:

5142102, 546221, 514327, 544130, 5142355, 546208, 514326, 544 582, 5142278, 546209, 514318, 546210, 546 17, 514278, 546213, 544360, 51425312, 5142362, 546188, 514316, 546207, 544329, 514256, 544 3, 5142222, 544105, 544 11, 5142228, 546 90, 514291, 546216, 544336, 51425505, 544332, 514275, 546198, 514321, 5142305

Abstract:

The present invention provides MDM inhibitor compounds of Formula I,

US Patent:

20190062276, Feb 28, 2019

Filed:

Mar 21, 2018

Appl. No.:

15/927426

Inventors:

- Thousand Oaks CA, US
Ana Gonzalez Buenrostro - San Mateo CA, US
Hilary Plake Beck - Emerald Hills CA, US
Xiaoqi Chen - Palo Alto CA, US
Richard Victor Connors - Scottsdale AZ, US
Jeffrey Deignan - San Francisco CA, US
Jason A. Duquette - Millbrae CA, US
John Eksterowicz - San Francisco CA, US
Benjamin Fisher - San Mateo CA, US
Brian M. Fox - Brisbane CA, US
Jiasheng Fu - Foster City CA, US
Zice Fu - Foster City CA, US
Felix Gonzalez Lopez De Turiso - Cambridge MA, US
Darin J. Gustin - Half Moon Bay CA, US
Julie A. Heath - Chico CA, US
Xin Huang - Wellesley MA, US
XianYun Jiao - Belmont CA, US
Michael G. Johnson - San Francisco CA, US
Frank Kayser - San Francisco CA, US
David John Kopecky - Studio City CA, US
SuJen Lai - Boston MA, US
Yihong Li - Johns Creek GA, US
Zhihong Li - Millbrae CA, US
Jiwen Liu - Foster City CA, US
Jonathan D. Low - Reseda CA, US
Brian S. Lucas - Arlington MA, US
Zhihua Ma - Lexington MA, US
Lawrence R. McGee - Pacifica CA, US
Joel McIntosh - Pacifica CA, US
Dustin L. McMinn - Pacifica CA, US
Julio C. Medina - San Carlos CA, US
Jeffrey Thomas Mihalic - San Francisco CA, US
Steven H. Olson - Millbrae CA, US
Yosup Rew - Foster City CA, US
Philip M. Roveto - Albuquerque NM, US
Daqing Sun - Foster City CA, US
Xiaodong Wang - Johns Creek GA, US
Yingcai Wang - Millbrae CA, US
Xuelei Yan - Foster City CA, US
Ming Yu - Foster City CA, US
Jiang Zhu - Palo Alto CA, US

International Classification:

C07D 211/76
C07D 279/02
C07D 405/12
C07D 405/04
C07D 491/153
C07D 407/04
C07D 401/12
C07D 401/06
C07D 417/06
C07D 413/06
C07D 491/08
C07D 401/04
C07D 471/10
C07D 221/20
C07D 417/14
C07D 498/08
C07D 409/04
C07D 407/06
C07D 417/12
C07D 498/14
C07D 409/12
C07D 498/20

Abstract:

The present invention provides MDM2 inhibitor compounds of Formula I,

US Patent:

20170144971, May 25, 2017

Filed:

Jan 23, 2017

Appl. No.:

15/412804

Inventors:

- Thousand Oaks CA, US
Ana GONZALEZ BUENROSTRO - San Mateo CA, US
Hilary Plake BECK - Emerald Hills CA, US
Xiaoqi CHEN - Palo Alto CA, US
Richard Victor CONNORS - Scottsdale AZ, US
Jeffrey DEIGNAN - San Francisco CA, US
Jason A. DUQUETTE - Millbrae CA, US
John EKSTEROWICZ - San Francisco CA, US
Benjamin FISHER - San Mateo CA, US
Brian M. FOX - Brisbane CA, US
Jiasheng FU - Foster City CA, US
Zice FU - Foster City CA, US
Felix GONZALEZ LOPEZ DE TURISO - Cambridge MA, US
Darin J. GUSTIN - Half Moon Bay CA, US
Julie A. HEATH - Chico CA, US
Xin HUANG - Wellesley MA, US
XianYun JIAO - Belmont CA, US
Michael G. JOHNSON - San Francisco CA, US
Frank KAYSER - San Francisco CA, US
David John KOPECKY - Studio City CA, US
SuJen LAI - Boston MA, US
Yihong LI - Johns Creek GA, US
Zhihong LI - Millbrae CA, US
Jiwen LIU - Foster City CA, US
Jonathan D. LOW - Reseda CA, US
Brian S. LUCAS - Arlington MA, US
Zhihua MA - Lexington MA, US
Lawrence R. MCGEE - Pacifica CA, US
Joel MCINTOSH - Pacifica CA, US
Dustin L. MCMINN - Pacifica CA, US
Julio C. MEDINA - San Carlos CA, US
Jeffrey Thomas MIHALIC - San Francisco CA, US
Steven H. OLSON - Millbrae CA, US
Yosup REW - Foster City CA, US
Phillip M. ROVETO - Albuquerque NM, US
Daqing SUN - Foster City CA, US
Xiaodong WANG - Johns Creek GA, US
Yingcai WANG - Millbrae CA, US
Xuelei YAN - Foster City CA, US
Ming YU - Foster City CA, US
Jiang ZHU - Palo Alto CA, US

Assignee:

AMGEN INC. - Thousand Oaks CA

International Classification:

C07D 211/76
C07D 417/12
C07D 413/06
C07D 471/10
C07D 409/04
C07D 417/06
C07D 405/04
C07D 401/04
C07D 279/02
C07D 401/12
C07D 491/08
C07D 498/08
C07D 409/12
C07D 405/12
C07D 417/14
C07D 498/20
C07D 401/06

Abstract:

The present invention provides MDM2 inhibitor compounds of Formula I,

US Patent:

20160137667, May 19, 2016

Filed:

Jan 27, 2016

Appl. No.:

15/008342

Inventors:

- Thousand Oaks CA, US
Ana GONZALEZ BUENROSTRO - San Mateo CA, US
Hilary Plake BECK - Emerald Hills CA, US
Xiaoqi CHEN - Palo Alto CA, US
Richard Victor CONNORS - Scottsdale AZ, US
Jeffrey DEIGNAN - San Francisco CA, US
Jason A. DUQUETTE - Millbrae CA, US
John EKSTEROWICZ - San Francisco CA, US
Benjamin FISHER - San Mateo CA, US
Brian M. FOX - Brisbane CA, US
Jiasheng FU - Foster City CA, US
Zice FU - Foster City CA, US
Felix GONZALEZ LOPEZ DE TURISO - Cambridge MA, US
Darin J. GUSTIN - Half Moon Bay CA, US
Julie A. HEATH - Chico CA, US
Xin HUANG - Wellesley MA, US
XianYun JIAO - Belmont CA, US
Michael G. JOHNSON - San Francisco CA, US
Frank KAYSER - San Francisco CA, US
David John KOPECKY - Studio City CA, US
SuJen LAI - Boston MA, US
Yihong LI - Johns Creek GA, US
Zhihong LI - Millbrae CA, US
Jiwen LIU - Foster City CA, US
Jonathan D. LOW - Reseda CA, US
Brian S. LUCAS - Arlington MA, US
Zhihua MA - Lexington MA, US
Lawrence R. MCGEE - Pacifica CA, US
Joel MCINTOSH - Pacifica CA, US
Dustin L. MCMINN - Pacifica CA, US
Julio C. MEDINA - San Carlos CA, US
Jeffrey Thomas MIHALIC - San Francisco CA, US
Steven H. OLSON - Millbrae CA, US
Yosup REW - Foster City CA, US
Phillip M. ROVETO - Albuquerque NM, US
Daqing SUN - Foster City CA, US
Xiaodong WANG - Johns Creek GA, US
Yingcai WANG - Millbrae CA, US
Xuelei YAN - Foster City CA, US
Ming YU - Foster City CA, US
Jiang ZHU - Palo Alto CA, US

Assignee:

AMGEN INC. - Thousand Oaks CA

International Classification:

C07D 498/14
C07D 221/20
C07D 471/10

Abstract:

The present invention provides MDM2 inhibitor compounds of Formula I,

Address:

538 Pleasant St, Birmingham, MI 48009

Phone:

(248)3798912

VIN:

1FMHK8D87CGA08194

Make:

FORD

Model:

EXPLORER

Year:

2012