Benjamin R Grant

US Patent:

20210055282, Feb 25, 2021

Filed:

Nov 6, 2020

Appl. No.:

17/091501

Inventors:

- Schenectady NY, US
- Bellevue WA, US
Cathryn Ellen Olsen - Wilton NY, US
John Richard Nelson - Clifton NY, US
David Roger Moore - Rexford NY, US
Paul Michael Smigelski - Glenville NY, US
John Thomas Connelly - Seattle WA, US
Benjamin David Grant - Bellevue WA, US
Bernhard Hans Weigl - Seattle WA, US

International Classification:

G01N 33/493
C07K 1/22
B01D 15/08
G01N 33/50
G01N 33/569
B01D 63/02
A61B 10/00
C12M 1/26
G01N 33/558

Abstract:

A device for rapid detection of a tuberculosis lipoarabinomannan (TB-LAM) is provided. The device includes a pre-concentrator unit for concentrating the TB-LAM comprising: an ion-exchange medium comprising one or more ligands configured to capture the TB-LAM from the source biological sample, wherein the captured-TB-LAM is eluted from the ion-exchange medium as an eluate comprising a concentrated form of TB-LAM; a cassette; a lateral flow assay unit disposed in the cassette; and an integration unit attached to the pre-concentrator unit and the cassette. The integration unit is configured to operatively couple and de-couple the pre-concentrator unit and the cassette. The pre-concentrator unit and the lateral flow assay unit disposed in the cassette are in a fluidic communication in a coupled form. The device for rapid detection of TB-LAM further comprises a dilutor unit.

US Patent:

20190187126, Jun 20, 2019

Filed:

Dec 20, 2017

Appl. No.:

15/848302

Inventors:

- Schenectady NY, US
- Bellevue WA, US
Cathryn Ellen OLSEN - Wilton NY, US
John Richard NELSON - Clifton Park NY, US
David Roger MOORE - Rexford NY, US
John Thomas CONNELLY - Seattle WA, US
Benjamin David GRANT - Bellevue WA, US
Bernhard Hans WEIGL - Seattle WA, US

International Classification:

G01N 33/493
C07K 1/22
B01D 15/08
G01N 33/50
G01N 33/569
B01D 63/02
C12M 1/26
A61B 10/00

Abstract:

A device for rapid detection of a tuberculosis lipoarabinomannan (TB-LAM) is provided. The device includes a pre-concentrator unit for concentrating the TB-LAM comprising: an ion-exchange medium comprising one or more ligands configured to capture the TB-LAM from the source biological sample, wherein the captured-TB-LAM is eluted from the ion-exchange medium as an eluate comprising a concentrated form of TB-LAM; a cassette; a lateral flow assay unit disposed in the cassette; and an integration unit attached to the pre-concentrator unit and the cassette. The integration unit is configured to operatively couple and de-couple the pre-concentrator unit and the cassette. The pre-concentrator unit and the lateral flow assay unit disposed in the cassette are in a fluidic communication in a coupled form. The device for rapid detection of TB-LAM further comprises a dilutor unit.