Benjamin Grant Jones

US Patent:

20080293696, Nov 27, 2008

Filed:

Jun 23, 2005

Appl. No.:

11/630850

Inventors:

Catherine Brennan - Durham NC, US
Julie A. Dixon - Bethany CT, US
William J. Scott - Guilford CT, US
Aniko Redman - Derby CT, US
Benjamin D. Jones - New Haven CT, US
Barton Phillips - New Haven CT, US
Philip Wickens - Wallingford CT, US
Istvan Enyedy - Milton MA, US
Ellalahewage Kumarasinghe - Hamden CT, US
Charles Kreiman - Wallingford CT, US
Jacques Dumas - Bethany CT, US
Uday Khire - Orange CT, US
Chih-Yuan Chuang - San Mateo CA, US
Harold C.E. Kluender - Trumbull CT, US
Zhenqiu Hong - Milford CT, US
Lei Wang - New Haven CT, US
Donald Bierer - Bethany CT, US

Assignee:

Bayer Pharmaceuticals Corporation - West Haven CT

International Classification:

A61K 31/55
C07D 405/12
A61K 31/4433
A61K 31/444
A61P 35/00
C07D 405/14
A61K 31/506

US Classification:

51421704, 5462824, 514338, 514333, 546256, 544333, 514256, 540597

Abstract:

A compound having the formula (1)in which the ring containing E is a phenyl, a pyridine, or a pyrimidine. In formula (1) the symbol A representswherein the group Rrepresents halogen, CF, or H, provided that the maximum number of CFgroups on any A is 2, and the maximum number of hydrogens on A is 2 for the A groups which together with the carbon atoms to which they are attached form 6-membered rings, and the maximum number of hydrogens on A is 1 for the A group which together with the carbon atoms to which it is attached forms a 5-membered ring. Z represents N or CH when E forms a phenyl ring, and represents CH when E forms a pyridine or pyrimidine. The groups R, Rand Rand the subscripts a, b, and d are as defined in the text and claims. Pharmaceutical compositions containing a compound of formula (1) and methods of treating cancer using compounds of formula (1) are also disclosed and claimed.

US Patent:

20130225809, Aug 29, 2013

Filed:

Dec 20, 2012

Appl. No.:

13/722793

Inventors:

Bayer HealthCare LLC - , US
Catherine Brennan - Durham NC, US
Karl Miranda - Lexington MA, US
Brent Chandler - New Haven CT, US
Barton Phillips - New Haven CT, US
Jianmei Fan - Newton MA, US
Michael Brands - Wuppertal, DE
Andrea McClure - West Haven CT, US
Benjamin D. Jones - New Haven CT, US
Wenlang Fu - Milford CT, US
Donald Bierer - Bethany CT, US
Steven Magnuson - Wallingford CT, US
Harold C.E. Kluender - Trumbull CT, US

Assignee:

Bayer HealthCare LLC - Tarrytown NY

International Classification:

C07D 491/113
C07D 487/04

US Classification:

544112, 544183

Abstract:

This invention relates to pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and the use of those compounds and compositions for the prevention and/or treatment of hyper-proliferative disorders and diseases associated with angiogenesis.