Benjamin R Shepherd

US Patent:

7029838, Apr 18, 2006

Filed:

Mar 29, 2002

Appl. No.:

10/112461

Inventors:

Stuart K. Williams - Tucson AZ, US
James B. Hoying - Tucson AZ, US
Benjamin R. Shepherd - Tucson AZ, US

Assignee:

Arizona Board of Regents on behalf of the University of Arizona - Tucson AZ

International Classification:

A01N 1/00
A01N 65/00
C12N 5/02
C12N 5/00

US Classification:

435 11, 424 931, 435325, 435395

Abstract:

This application discloses methods and materials for preparing functional microvascular beds in the laboratory. These prevascularized constructs can be used to vascularize engineered tissue constructs or to revascularize damaged or diseased tissues or organs following implantation. The prevascularized constructs may also deliver genetically engineered gene products to the bloodstream.

US Patent:

7052829, May 30, 2006

Filed:

Apr 29, 2002

Appl. No.:

10/134939

Inventors:

Stuart K. Williams - Tucson AZ, US
James B. Hoying - Tucson AZ, US
Benjamin R. Shepherd - Tucson AZ, US

Assignee:

The Arizona Board of Regents on behalf of the University of Arizona - Tucson AZ

International Classification:

A01N 1/00
A01N 63/00
C12N 5/02
C12N 5/00

US Classification:

435 11, 424 931, 435325, 435395

Abstract:

This application discloses methods and materials for preparing functional microvascular beds in the laboratory. These prevascularized constructs can be used to vascularize engineered tissue constructs or to revascularize damaged or diseased tissues or organs following implantation. The prevascularized constructs may also deliver genetically engineered gene products to the bloodstream.

US Patent:

8626607, Jan 7, 2014

Filed:

Aug 31, 2011

Appl. No.:

13/222761

Inventors:

James H. Wood - Seattle WA, US
Patrick C. Teo - San Carlos CA, US
Benjamin L. Shepherd - Issaquah WA, US
Korwin J. Smith - Seattle WA, US
Scott Durham - Seattle WA, US
Piragash Velummylum - Seattle WA, US
Emily J. Butler - San Francisco CA, US

Assignee:

Amazon Technologies, Inc. - Reno NV

International Classification:

G06Q 30/00

US Classification:

705 267, 705 2641

Abstract:

Disclosed are various embodiments relating to generating media item recommendations based upon determining a beats per minute value. A media recommendation application determines a beats per minute value based upon the activity of a user. The media recommendation application then identifies one or more media item candidates having a number of beats per minute within a predefined delta of the beats per minute value. The media recommendation application then filters out the media items possessed and information associated with the user to identify a subset of the media item candidates to surface as recommendations.

US Patent:

20060188488, Aug 24, 2006

Filed:

Apr 18, 2006

Appl. No.:

11/406950

Inventors:

Stuart Williams - Tucson AZ, US
James Hoying - Tucson AZ, US
Benjamin Shepherd - Tucson AZ, US

Assignee:

The Arizona Board of Regents on behalf of The University of Arizona - Tucson AZ

International Classification:

A61K 35/12
C12N 5/08

US Classification:

424093700, 435366000

Abstract:

This application discloses methods and materials for preparing functional microvascular beds in the laboratory. These prevascularized constructs can be used to vascularize engineered tissue constructs or to revascularize damaged or diseased tissues or organs following implantation. The prevascularized constructs may also deliver genetically engineered gene products to the bloodstream.

US Patent:

20090220569, Sep 3, 2009

Filed:

May 11, 2009

Appl. No.:

12/464041

Inventors:

Stuart K. Williams - Tucson AZ, US
James B. Hoying - Tucson AZ, US
Benjamin R. Shepherd - Tucson AZ, US

Assignee:

The Arizona Board of Regents on behalf of the University of Arizona - Tucson AZ

International Classification:

A61F 2/00
C12N 5/00
A01N 1/02
C12N 5/08
A61K 35/12

US Classification:

424423, 435395, 435 11, 435366, 424 937, 424 9321

Abstract:

This application discloses methods and materials for preparing functional microvascular beds in the laboratory. These prevascularized constructs can be used to vascularize engineered tissue constructs or to revascularize damaged or diseased tissues or organs following implantation. The prevascularized constructs may also deliver genetically engineered gene products to the bloodstream.

US Patent:

20130164339, Jun 27, 2013

Filed:

Sep 12, 2012

Appl. No.:

13/612778

Inventors:

Keith Murphy - Palos Verdes Estates CA, US
Chirag Khatiwala - San Diego CA, US
Scott Dorfman - San Diego CA, US
Benjamin Shepherd - San Diego CA, US
Sharon Presnell - San Diego CA, US

Assignee:

ORGANOVO, INC. - San Diego CA

International Classification:

A61L 27/36
A01N 1/02
A61L 27/38

US Classification:

424400, 424 937, 424 933, 435 2, 427 224

Abstract:

Disclosed are engineered tissues and organs comprising one or more muscle cell-containing layers, the engineered tissue or organ consisting essentially of cellular material, provided that the engineered tissue or organ is implantable in a vertebrate subject and not a vascular tube.

US Patent:

20130190210, Jul 25, 2013

Filed:

Sep 12, 2012

Appl. No.:

13/612768

Inventors:

Keith Murphy - Palos Verdes Estates CA, US
Chirag Khatiwala - San Diego CA, US
Scott Dorfman - San Diego CA, US
Benjamin Shepherd - San Diego CA, US
Sharon Presnell - San Diego CA, US
Justin Robbins - La Jolla CA, US

Assignee:

ORGANOVO, INC. - San Diego CA

International Classification:

G01N 33/50

US Classification:

506 14, 435325, 435401, 435402, 435 29, 506 26, 264309

Abstract:

Disclosed are living, three-dimensional tissue constructs for in vitro scientific and medical research, arrays thereof, and methods of making said tissues and arrays.

US Patent:

20130345794, Dec 26, 2013

Filed:

Mar 16, 2011

Appl. No.:

13/634863

Inventors:

Chirag Khatiwala - San Diego CA, US
Keith Murphy - Palos Verdes Estates CA, US
Benjamin Shepherd - San Diego CA, US

Assignee:

ORGANOVO, INC. - San Diego CA

International Classification:

A61F 2/06

US Classification:

623 135, 623 141

Abstract:

Described herein are engineered multilayered vascular tubes comprising at least one layer of differentiated adult fibroblasts, at least one layer of differentiated adult smooth muscle cells, wherein any layer further comprises differentiated adult endothelial cells, wherein said tubes have the following features: (a) a ratio of endothelial cells to smooth muscle cells of about 1:99 to about 45:55; (b) the tube is compliant; (c) the internal diameter of the tube is about 6 mm or smaller; (d) the length of the tube is up to about 30 cm; and (e) the thickness of the tube is substantially uniform along a region of the tube; provided that the engineered multilayered vascular tube is free of any pre-formed scaffold. Also described herein are methods of forming said tubes and uses for said tubes including methods for treating patients, comprising providing such a tube into to a patient in need thereof.