Dr. Fine graduated from the Harvard Medical School in 1996. He works in Palo Alto, CA and specializes in Hematology/Oncology. Dr. Fine is affiliated with VA Palo Alto Health Care System.
Hongyue Dai - Kenmore WA, US Yudong He - Kirkland WA, US Mao Mao - Redmond WA, US Bernard Fine - Menlo Park CA, US Laura J. van't Veer - Amsterdam, NL Marc J. van de Vijver - Amsterdam, NL
International Classification:
C12Q 1/68 G06F 19/00
US Classification:
435 6, 702 19
Abstract:
The present invention relates to sets of genetic markers whose expression is correlated with prognosis of breast cancer in individuals having breast cancer. Specifically, the invention provides sets of markers whose expression patterns can be used to differentiate individuals having a good prognosis, e.g., no reoccurrence or metastasis within five years of initial diagnosis, and individuals having a poor prognosis, e.g., reoccurrence or metastasis within five years of initial diagnosis. The invention relates to methods of prognosis using these markers. The invention also relates to microarrays containing probes to these markers, and to kits containing ready-to-use microarrays and computer software for data analysis using the prognostic and statistical methods disclosed herein.
Methods Of Using Saha And Bortezomib For Treating Cancer
Stanley R. Frankel - Yardley PA, US Paul J. Deutsch - Princeton NJ, US Sophia Randolph - Burien WA, US Bernard Fine - Menlo Park CA, US
International Classification:
A61K 31/497 A61P 35/00
US Classification:
51425505
Abstract:
The present invention relates to a method of treating cancer in a subject in need thereof, by administering to a subject in need thereof a first amount of a histone deacetylase (HDAC) inhibitor such as suberoylanilide hydroxamic acid (SAHA), or a pharmaceutically acceptable salt or hydrate thereof, and a second amount of one or more anti-cancer agents, including Bortezomib. The HDAC inhibitor and the anti-cancer agent may be administered to comprise therapeutically effective amounts. In various aspects, the effect of the HDAC inhibitor and the anti-cancer agent may be additive or synergistic.
Methods Of Using Saha And Bortezomib For Treating Cancer
Stanley Frankel - Yardley PA, US Paul Deutsch - Princeton NJ, US Sophia Randolph - Burien WA, US Bernard Fine - Menlo Park CA, US
International Classification:
A61K 31/69 A61K 31/19
US Classification:
514064000, 514575000
Abstract:
The present invention relates to a method of treating cancer in a subject in need thereof, by administering to a subject in need thereof a first amount of a histone deacetylase (HDAC) inhibitor such as suberoylanilide hydroxamic acid (SAHA), or a pharmaceutically acceptable salt or hydrate thereof, and a second amount of one or more anti-cancer agents, including Bortezomib. The HDAC inhibitor and the anti-cancer agent may be administered to comprise therapeutically effective amounts. In various aspects, the effect of the HDAC inhibitor and the anti-cancer agent may be additive or synergistic.
Name / Title
Company / Classification
Phones & Addresses
Bernard Martin Fine
Bernard Fine MD,PHD Internist
3801 Miranda Ave, Palo Alto, CA 94304 (650)4935000
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