Bernard L Hirschbein from 1629 York St, San Francisco, CA 94110, age 73, Phone: (415)6416126

Name / Title

Company / Classification

Phones & Addresses

Bernard Hirschbein
President

Imajazz
Photographers-Portrait · Photography Studios, Portrait

1629 York St, San Francisco, CA 94110
(415)8240417

Us Patents

Cathepsin Cysteine Protease Inhibitors
view source
US Patent:

7973037, Jul 5, 2011
Filed:

Apr 8, 2008
Appl. No.:

12/082104
Inventors:

Christopher I. Bayly - Beaconsfield, CA
Cameron Black - Baie d'Urfe, CA
Serge Leger - Notre-Dame-de I'lle-Perrot, CA
Chun Sing Li - Dollard-des-Ormeaux, CA
Dan McKay - Ottawa, CA
Christophe Mellon - L'ile-Bizard, CA
Jacques Yves Gauthier - Laval, CA
Vouy-Linh Truong - Pierrefonds, CA
Cheuk Lau - Ile Bizard, CA
Michel Therien - Laval, CA
Michael J. Green - Half Moon Bay CA, US
Bernard L. Hirschbein - San Francisco CA, US
James William Janc - Burlingame CA, US
James T. Palmer - Corte Madera CA, US
Chitra Baskaran - Foster City CA, US
Assignee:

Axys Pharmaceuticals, Inc. - South San Francisco CA
Merck Canada Inc. - Quebec
International Classification:

A61K 31/535
A61K 31/497
A61K 31/435
A61K 31/385
C07D 265/30
C07D 241/04
C07D 211/08
C07D 333/02
C07D 255/03
US Classification:

5142312, 51425212, 514277, 514439, 514520, 514526, 544158, 544358, 544360, 546192, 546265, 549 29, 558437, 558438, 558439, 558440
Abstract:

This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.

Cathepsin Cysteine Protease Inhibitors
view source
US Patent:

8318748, Nov 27, 2012
Filed:

May 25, 2011
Appl. No.:

13/115462
Inventors:

Christopher I. Bayly - Beaconsfield, CA
Cameron Black - Baie d'Urfe, CA
Serge Leger - Notre-Dame-de I'lle-Perrot, CA
Chun Sing Li - Dollard-des-Ormeaux, CA
Dan McKay - Ottawa, CA
Christophe Mellon - L'lle-Bizard, CA
Jacques Yves Gauthier - Laval, CA
Vouy-Linh Truong - Pierrefonds, CA
Cheuk Lau - L'lle Bizard, CA
Michel Therien - Laval, CA
Michael J. Green - Half Moon Bay CA, US
Bernard L. Hirschbein - San Francisco CA, US
James William Janc - Burlingame CA, US
James T. Palmer - Corte Madera CA, US
Chitra Baskaran - Foster City CA, US
Assignee:

Merck, Sharp & Dohme Corp. - Rahway NJ
Axys Pharmaceuticals, Inc. - South San Francisco CA
International Classification:

A61K 31/4965
A61K 31/66
A61K 31/44
A61K 31/445
A61K 31/425
A61K 31/415
US Classification:

51425503, 514102, 514321, 514357, 514365, 514400
Abstract:

This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.

Separation Of Pyrophosphate Release And Pyrophosphate Detection
view source
US Patent:

8445412, May 21, 2013
Filed:

Feb 24, 2010
Appl. No.:

13/203463
Inventors:

Bernard Hirschbein - Hayward CA, US
Assignee:

Illumina, Inc. - San Diego CA
International Classification:

C12Q 1/66
C12Q 1/68
C12Q 1/48
C12Q 1/42
C40B 40/06
C40B 50/14
US Classification:

506 16, 435 61, 435 15, 435 8, 435 4, 435 21, 435 18, 506 30
Abstract:

The present technology relates to methods and systems for detection of pyrophosphate. As such, disclosed herein are methods and systems that permit improved pyrophosphate detection. Also disclosed herein are methods and systems which utilize improved pyrophosphate detection for nucleotide sequencing.

Cathepsin Cysteine Protease Inhibitors
view source
US Patent:

20030232863, Dec 18, 2003
Filed:

Feb 28, 2003
Appl. No.:

10/377377
Inventors:

Christopher Bayly - Beaconsfield, CA
Cameron Black - Baie d'Urfe, CA
Serge Leger - Notre-Dame-de I'lle-Perrot, CA
Chun Li - Dollard-Des-Ormeaux, CA
Dan McKay - Ottawa, CA
Christophe Mellon - L'ile-Bizard, CA
Jacques Gauthier - Laval, CA
Vouy-Linh Truong - Pierrefonds, CA
Cheuk Lau - Ile Bizard, CA
Michel Therien - Laval, CA
Michael Green - Half Moon Bay CA, US
Bernard Hirschbein - San Francisco CA, US
James Janc - Burlingame CA, US
James Palmer - Corte Madera CA, US
Chitra Baskaran - Foster City CA, US
International Classification:

A61K031/44
A61K031/277
C07D213/57
C07C255/42
US Classification:

514/357000, 514/521000, 546/330000, 558/393000
Abstract:

This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.

Cathepsin Cysteine Protease Inhibiors
view source
US Patent:

20130035312, Feb 7, 2013
Filed:

Oct 11, 2012
Appl. No.:

13/649670
Inventors:

Axys Pharmaceuticals, Inc. - South San Francisco CA, US
Serge Leger - Notre-Dame-de l'lle-Perrot, CA
Chun Sing Li - Dollard-Des-Ormeaux, CA
Dan McKay - Ottawa, CA
Christophe Mellon - L'lle-Bizard, CA
Jacques Yves Gauthier - Laval, CA
Vouy-Linh Truong - Pierrefonds, CA
Cheuk Lau - L'lle Bizard, CA
Michel Therien - Laval, CA
Michael J. Green - Half Moon Bay CA, US
Bernard L. Hirschbein - San Francisco CA, US
James William Janc - Burlingame CA, US
James T. Palmer - Corte Madera CA, US
Chitra I. Baskaran - Foster City CA, US
Assignee:

Axys Pharmaceuticals, Inc. - South San Francisco CA
Merck, Sharp & Dohme, Corp. - Rahway NJ
International Classification:

A61K 31/277
A61K 31/4418
A61K 31/44
A61K 31/426
A61K 31/4174
A61P 19/02
A61K 31/381
A61K 31/42
A61K 31/404
A61K 31/505
A61K 31/47
A61K 31/69
A61K 31/495
A61K 31/5375
US Classification:

514 64, 514521, 51425503, 514357, 514365, 514400, 5142375, 514438, 514378, 514415, 514256, 514311, 5142388
Abstract:

This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.

Method Of Synethesizing Sulfurized Oligonucleotide Analogs
view source
US Patent:

51515105, Sep 29, 1992
Filed:

Apr 20, 1990
Appl. No.:

7/512644
Inventors:

Wojciech J. Stec - Lodz, PL
Bogdan Uznanski - Lodz, PL
B. John Bergot - Redwood City CA
Bernard L. Hirschbein - San Francisco CA
Karen L. Fearon - Union City CA
Assignee:

Applied Biosystems, Inc. - Foster City CA
International Classification:

C07H 1512
C07H 1700
A01N 4304
C12Q 168
US Classification:

536 27
Abstract:

A method for synthesizing sulfurized oligonucleotide analogs, such as phosphorothioate and phosphorodithioate analogs, is provided that employs a thiophosphorus compound, such as a thiophosphoric, dithiophosphoric, thiophosphinic, or dithiophosphinic acid disulfide or polysulfide, as a sulfurizing agent. The method of the invention may be used to sulfurize any phosphorous(III)-containing intermediate. Preferably, the method is practiced on a commercial DNA synthesizer using phosphoramidite and/or phosphorthioamidite intermediates.

Process For The Preparation Of The Potassium Salt Of Phosphoenolpyruvic Acid
view source
US Patent:

44787626, Oct 23, 1984
Filed:

Mar 30, 1982
Appl. No.:

6/416391
Inventors:

George M. Whitesides - Newton MA
Bernard L. Hirschbein - Somerville MA
Francois P. Mazenod - Geneva, CH
Assignee:

Massachusetts Institute of Technology - Cambridge MA
International Classification:

C07F 940
US Classification:

260983
Abstract:

The potassium salt of phosphoenolpyruvic acid (PEP-K), used as a phosphorylation agent particularly in enzymatic reactions, is prepared by a process which consists of two steps, namely the treatment of a halopyruvic acid with a trialkyl phosphite and the hydrolysis of the dialkyl phosphate of enolpyruvic acid thus formed in an aqueous medium and in the presence of potassium hydroxide.

Method Of Synthesizing Sulfurized Oligonucleotide Analogs
view source
US Patent:

52928756, Mar 8, 1994
Filed:

Aug 27, 1993
Appl. No.:

8/113725
Inventors:

Wojciech J. Stec - Lodz, PL
Bogdan Uznanski - Lodz, PL
B. John Bergot - Redwood City CA
Bernard L. Hirschbein - San Francisco CA
Karen L. Fearson - Union City CA
Assignee:

Lynx Therapeutics, Inc. - Foster City CA
International Classification:

C07H 2100
US Classification:

536 2533
Abstract:

A method for synthesizing sulfurized oligonucleotide analogs, such as phosphorothioate and phosphorodithioate analogs, is provided that employs a thiophosphorus compound, such as a thiophosphoric, dithiophosphoric, thiophosphinic, or dithiophosphinic acid disulfide or polysulfide, as a sulfurizing agent. The method of the invention may be used to sulfurize any phosphorous(III)containing intermediate. Preferably, the method is practiced on a commercial DNA synthesizer using phosophoramidite and/or phosphorthioamidite intermediates.

Bernard L Hirschbein

Bernard Hirschbein Phones & Addresses

Us Patents

Cathepsin Cysteine Protease Inhibitors

Cathepsin Cysteine Protease Inhibitors

Separation Of Pyrophosphate Release And Pyrophosphate Detection

Cathepsin Cysteine Protease Inhibitors

Cathepsin Cysteine Protease Inhibiors

Method Of Synethesizing Sulfurized Oligonucleotide Analogs

Process For The Preparation Of The Potassium Salt Of Phosphoenolpyruvic Acid

Method Of Synthesizing Sulfurized Oligonucleotide Analogs

Mylife

Bernard Hirschbein San F...