David B. Reisner - Hightstown NJ Bernard J. Ludwig - North Brunswick NJ George M. Fukui - Princeton NJ Frank M. Berger - New York NY
Assignee:
Carter-Wallace, Inc. - New York NY
International Classification:
A61K 3122
US Classification:
424311
Abstract:
A method for suppressing the release of histamine from sensitized leukocytes in warm blooded animals which comprises administering internally to said animals compounds of the formula: ##STR1## wherein n is a whole integer from 1 to 4; X is halogen and Z is COOH, CH. sub. 2 OR or ##STR2## R being a lower alkyl chain of from 1 to 6 carbon atoms and pharmaceutically acceptable salts of those compounds wherein Z is COOH, in sufficient amount to suppress the release of histamine from said cells.
David B. Reisner - Hightstown NJ Bernard J. Ludwig - North Brunswick NJ Harold M. Bates - East Brunswick NJ Frank M. Berger - Princeton NJ
Assignee:
Carter-Wallace, Inc. - New York NY
International Classification:
C07D49802
US Classification:
260244R
Abstract:
Chemical compounds of the formula: ##STR1## wherein X is hydrogen, hydroxy, halogen, lower alkyl, lower alkoxy, nitro, amino, acetamido, sulfonamido or trifluoromethyl, and each R is selected from the group consisting of hydrogen and lower alkyl. Said compounds have valuable anti-inflammatory activity in standard laboratory animals.