Bernard J Ludwig

US Patent:

41247230, Nov 7, 1978

Filed:

Feb 18, 1977

Appl. No.:

5/770062

Inventors:

David B. Reisner - Hightstown NJ
Bernard J. Ludwig - North Brunswick NJ
George M. Fukui - Princeton NJ
Frank M. Berger - New York NY

Assignee:

Carter-Wallace, Inc. - New York NY

International Classification:

A61K 3122

US Classification:

424311

Abstract:

A method for suppressing the release of histamine from sensitized leukocytes in warm blooded animals which comprises administering internally to said animals compounds of the formula: ##STR1## wherein n is a whole integer from 1 to 4; X is halogen and Z is COOH, CH. sub. 2 OR or ##STR2## R being a lower alkyl chain of from 1 to 6 carbon atoms and pharmaceutically acceptable salts of those compounds wherein Z is COOH, in sufficient amount to suppress the release of histamine from said cells.

US Patent:

40241394, May 17, 1977

Filed:

May 8, 1972

Appl. No.:

5/250909

Inventors:

David B. Reisner - Hightstown NJ
Bernard J. Ludwig - North Brunswick NJ
Harold M. Bates - East Brunswick NJ
Frank M. Berger - Princeton NJ

Assignee:

Carter-Wallace, Inc. - New York NY

International Classification:

C07D49802

US Classification:

260244R

Abstract:

Chemical compounds of the formula: ##STR1## wherein X is hydrogen, hydroxy, halogen, lower alkyl, lower alkoxy, nitro, amino, acetamido, sulfonamido or trifluoromethyl, and each R is selected from the group consisting of hydrogen and lower alkyl. Said compounds have valuable anti-inflammatory activity in standard laboratory animals.