Bin B Chen

US Patent:

6372879, Apr 16, 2002

Filed:

Jun 29, 2001

Appl. No.:

09/895990

Inventors:

Conor M. Dowling - Blue Bell PA
Bin Chen - Wayne PA
Sri R. Seshadri - Holland PA

Assignee:

ATOFINA Chemicals, Inc. - Philadelphia PA

International Classification:

C08G 6302

US Classification:

528279, 528275, 528285, 5283081, 5283083, 502103, 502113, 502118, 502161, 502170

Abstract:

The present invention is based upon the discovery that nontitanyl oxalates can enhance the catalytic functionality of titanyl oxalate catalysts. This invention provides a novel catalytic composition containing a titanyl oxalate catalyst and a metallic oxalate catalyst enhancer and optionally containing a metallic cocatalyst such as an antimony based catalyst. A synergistic relationship has been discovered between titanyl oxalate catalyst and the catalyst enhancer. A synergistic relationship has also been discovered between the titanyl oxalate catalyst, catalyst enhancer and a metallic cocatalyst such as antimony oxide or antimony triacetate. Also provided is an improved process of producing polyester by the polycondensation of polyester forming reactants in the presence of a catalytically effective amount of a polycondensation catalyst, wherein the improvement comprises utilizing, as the polycondensation catalyst, the novel catalyst composition containing a titanyl oxalate such as lithium titanyl oxalate and a catalyst enhancer such as a nontitanyl metallic oxalate like lithium oxalate and optionally containing a metallic catalyst such as antimony oxide or antimony triacetate. The improved process produces an improved polyester having lower acetaldehyde numbers and good color. The titanyl oxalate/catalyst enhancer composition can be used as a polycondensation catalyst in combination with other catalysts to achieve synergistic catalytic activity.

US Patent:

7590517, Sep 15, 2009

Filed:

May 28, 2003

Appl. No.:

10/446171

Inventors:

Robert Doerksen - Philadelphia PA, US
Bin Chen - Baton Rouge LA, US
William F. DeGrado - Media PA, US
Michael L. Klein - Ocean City NJ, US

Assignee:

The Trustees of the University of Pennsylvania - Philadelphia PA

International Classification:

G06G 7/48

US Classification:

703 11

Abstract:

Methods, systems, and computer program products for computational polymer processing including, without limitation, computational amphiphilic polymer design, conformational energy minimization, generation and refinement of torsional parameters for sub-units of potential polymers, generation of modified force field parameters, and prediction of conformational information for potential polymers. A target polymer backbone or portion thereof is identified. Small model compounds that have structural connectivities that are similar to structural connectivities of the target polymer backbone or portion thereof, are identified, whereby the combination of the small model compounds serve as a model of the target polymer or portion thereof. Gradient-corrected density functional theory (“DFT”) torsional potentials are calculated for the small model compounds, wherein energies are calculated at unconstrained and constrained geometries of the selected small model compounds. New torsional parameters are then obtained from the DFT torsional potentials.

US Patent:

20120101078, Apr 26, 2012

Filed:

Mar 19, 2010

Appl. No.:

13/256981

Inventors:

Bin Chen - East Windsor NJ, US
James Ford Burns - Glen Ridge NJ, US
Dario Doller - Sparta NJ, US

Assignee:

H. Lundbrck A/S - Valby-Copenhagen

International Classification:

A61K 31/4427
C07D 403/12
C07D 413/12
A61K 31/4439
A61K 31/497
A61K 31/4545
A61K 31/506
A61K 31/422
A61K 31/5355
A61K 31/513
A61K 31/5377
A61P 25/24
A61P 25/00
A61P 25/22
A61P 25/28
C07D 401/12

US Classification:

51421002, 5462784, 544336, 540362, 546194, 544332, 5462714, 548231, 544 96, 544316, 5462744, 544131, 544140, 544120, 544122, 514343, 51425505, 514318, 514275, 514340, 514376, 5142288, 514274, 514341, 5142308

Abstract:

Disclosed are a series of neuropeptide Y Y5 receptor ligands, and as such are useful to treat disorders related to mood, stress, ADHD, cognition, stress and dementia.

US Patent:

60138467, Jan 11, 2000

Filed:

Mar 5, 1998

Appl. No.:

9/035696

Inventors:

John A. Wismer - Lower Makefield PA
Michael S. Bolmer - Lower Providence PA
Bin Chen - Tredyffrin PA

Assignee:

Elf Atochem North America, Inc. - Philadelphia PA

International Classification:

C07C 1738

US Classification:

570180

Abstract:

An azeotrope containing HF and 1233zd is provided, as are methods for separating this azeotrope from mixtures of HF and 1233zd which are HF-rich or 1233zd-rich and methods for making use of the azeotrope and separation methods to improve processes for preparing 1233zd, an intermediate used in the preparation of 245fa. 245fa is a known foam blowing agent and refrigerant.

US Patent:

20160280659, Sep 29, 2016

Filed:

Nov 15, 2013

Appl. No.:

14/442624

Inventors:

- Princeton NJ, US
Bruce A. Ellsworth - Princeton NJ, US
William R. Ewing - Yardley NJ, US
Bin Chen - Lambertville NJ, US

International Classification:

C07D 231/06
C07D 231/08
C07D 403/04
A61K 31/4155
C07D 413/04
A61K 31/422
C07D 401/12
A61K 31/4439
C07D 403/10
A61K 31/506
C07D 401/04
C07D 403/12
C07D 401/10
A61K 31/497
A61K 45/06
A61K 31/415

Abstract:

The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR40 G protein-coupled receptor modulators which may be used as medicaments.

US Patent:

20160108050, Apr 21, 2016

Filed:

Dec 21, 2015

Appl. No.:

14/976476

Inventors:

- Princeton NJ, US
Brian E. Fink - Yardley PA, US
Walter Lewis Johnson - Waterbury CT, US
Amy C. Hart - Ewing NJ, US
Liqi He - Furlong PA, US
Tram N. Huynh - Pennington NJ, US
Harold Mastalerz - Guilford CT, US
Xiaopeng Sang - Glastonbury CT, US
Christine M. Tarby - Lawrenceville NJ, US
Honghe Wan - Pennington NJ, US
Wayne Vaccaro - Yardley PA, US
Guifen Zhang - Wallingford CT, US
Yufen Zhao - Pennington NJ, US
Kurt Zimmermann - Durham CT, US
Yong Zhang - Princeton Junction NJ, US
Libing Chen - Newtown PA, US
Bin Chen - Pennington NJ, US
John S. Tokarski - Princeton NJ, US
Ashvinikumar V. Gavai - Princeton Junction NJ, US

International Classification:

C07D 487/04
C07F 9/6561
C07F 7/18
C07D 519/00

Abstract:

The invention provides compounds of Formula (I)and pharmaceutically acceptable salts thereof. The Formula (I) imidazotriazines inhibit protein kinase activity thereby making them useful as anticancer agents.

US Patent:

20160060237, Mar 3, 2016

Filed:

Mar 12, 2014

Appl. No.:

14/775976

Inventors:

- Princeton NJ, US
Audris Huang - New Hope PA, US
Bin Chen - Lambertville NJ, US
Libing Chen - Newton PA, US
Weifang Shan - Princeton NJ, US

International Classification:

C07D 305/06
A61K 31/196
A61K 31/337
C07D 261/14
A61K 31/42
A61K 45/06
A61K 31/41
C07D 241/42
A61K 31/498
C07D 239/42
A61K 31/505
C07C 275/42
C07D 255/02

Abstract:

There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or autoimmune diseases utilizing the compounds of the invention. Formula (I).

US Patent:

20160022619, Jan 28, 2016

Filed:

Mar 12, 2014

Appl. No.:

14/776035

Inventors:

- Princeton NJ, US
Audris Huang - New Hope PA, US
Bin Chen - Lambertville NJ, US
Libing Chen - Newtown PA, US
Steven P. Seitz - Swarthmore PA, US
Amy C. Hart - Ewing NJ, US
Jay A. Markwalder - Lahaska PA, US

International Classification:

A61K 31/196
A61K 31/505
A61K 31/44
A61K 31/41
A61K 31/4245
A61K 31/42
A61K 31/36
A61K 31/27
A61K 31/216
A61K 31/18
C07D 239/42
C07D 241/42
C07D 213/84
C07D 213/75
C07D 271/12
C07D 261/14
C07D 257/04
C07D 317/66
C07C 271/28
C07C 69/743
C07C 275/42
C07C 311/47
A61K 45/06
C07C 233/55
A61N 5/10
A61K 31/498

Abstract:

There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.