Bin H Shao

US Patent:

8247442, Aug 21, 2012

Filed:

Mar 29, 2007

Appl. No.:

12/225743

Inventors:

Zhengming Chen - Belle Mead NJ, US
Khondaker Islam - Groton CT, US
Bin Shao - Richboro PA, US
Jiangchao Yao - Monmouth Junction NJ, US
Donald J. Kyle - Newtown PA, US

Assignee:

Purdue Pharma L.P. - Stamford CT

International Classification:

A61K 31/40
C07D 207/14

US Classification:

514426, 548557

Abstract:

The invention relates to azetidinyl, pyrrolidinyl, piperidinyl, and hexahydroazepinyl compounds of Formula I and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein R-Rand Z are defined as set forth in the specification. The invention is also directed to the use compounds of Formula I to treat, prevent or ameliorate a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.

US Patent:

8324249, Dec 4, 2012

Filed:

Aug 3, 2009

Appl. No.:

13/056839

Inventors:

Hidenori Mikamiyama - Osaka, JP
Chiyou Ni - Belle Mead NJ, US
Bin Shao - Richboro PA, US
Laykea Tafesse - Robbinsville NJ, US

Assignee:

Purdue Pharma L.P. - Stamford CT
Shionogi & Co., Ltd. - Osaka

International Classification:

A01N 43/40
A61K 31/445

US Classification:

514318, 514326, 544192, 544193, 544208, 544209, 544210, 544211

Abstract:

The invention relates to tetrahydropyridinyl and dihydropyrrolyl compounds of Formula (I): and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein X, Y, Z, R, R, m, and n are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.

US Patent:

20100022595, Jan 28, 2010

Filed:

Apr 13, 2007

Appl. No.:

12/296799

Inventors:

Zhengming Chen - Belle Mead NJ, US
Khondaker Islam - Groton CT, US
Donald J. Kyle - Newtown PA, US
Deyou Sha - Yardley PA, US
Bin Shao - Richboro PA, US
Jiangchao Yao - Monmouth Junction NJ, US
Xiaoming Zhou - Plainsboro NJ, US

Assignee:

Purdue Pharma L.P. - Stamford

International Classification:

A61K 31/445
C07D 211/56
G01N 23/00
A61P 29/00

US Classification:

514329, 546223, 436 57

Abstract:

The invention relates to piperidinyl and hexahydroazepinyl compounds of Formula (I): and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein R-R, Z and q are defined as set forth in the specification. The invention is also directed to the use compounds of Formula (I) to treat, prevent or ameliorate a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.

US Patent:

20130303526, Nov 14, 2013

Filed:

Sep 16, 2011

Appl. No.:

13/821732

Inventors:

Chiyou NI - Belle Mead NJ, US
Bin Shao - Richboro PA, US
Laykea Tafesse - Robbinsville NJ, US
Jiangchao Yao - Princeton NJ, US
Jianming Yu - Plainsboro NJ, US
Xiaoming Zhou - Plainsboro NJ, US

Assignee:

Purdue Pharma L.P. - Stamford CT

International Classification:

C07D 213/30
C07D 213/81
C07D 213/58
C07D 213/643
C07D 401/12
C07D 401/04
C07D 401/14

US Classification:

5142278, 5142372, 51425218, 51425313, 514256, 514277, 514318, 514332, 514333, 514335, 514339, 514341, 514352, 514354, 514357, 544 582, 544131, 544295, 544333, 544365, 546194, 546256, 546257, 546261, 5462727, 5462744, 5462781, 546309, 546323, 546337, 546339, 546344

Abstract:

The invention relates to substituted pyridine compounds of Formula (I) and the pharmaceutically acceptable salts, prodrugs, and solvates thereof, wherein R, A, A, E, G, Z, and Zare defined as set forth in the specification. The invention is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of sodium channels. Compounds of the present invention are especially useful for treating pain.

US Patent:

20140005212, Jan 2, 2014

Filed:

Dec 21, 2011

Appl. No.:

13/996082

Inventors:

Chiyou Ni - Belle Mead NJ, US
Minnie Park - West Windsor NJ, US
Bin Shao - Richboro PA, US
Laykea Tafesse - Robbinsville NJ, US
Jiangchao Yao - Princeton NJ, US
Mark Youngman - North Wales PA, US
Xiaoming Zhou - Plainsboro NJ, US

Assignee:

Purdue Pharma L.P. - Stamford CT

International Classification:

C07D 213/75
C07D 413/12
C07D 401/12
C07D 401/14
C07D 213/81
C07D 213/76

US Classification:

514272, 546309, 514352, 546262, 514332, 546312, 5462744, 514341, 546194, 514318, 5462721, 514340, 544321, 435 721

Abstract:

The invention relates to substituted pyridine compounds of Formula I: (I) and the pharmaceutically acceptable salts, prodrugs, and solvates thereof, wherein R, R, R, R, R, A, A, and X are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of sodium channels. Compounds of the present invention are especially useful for treating pain.

US Patent:

20170210713, Jul 27, 2017

Filed:

Apr 6, 2017

Appl. No.:

15/481150

Inventors:

- Stamford CT, US
Chiyou Ni - Belle Mead NJ, US
Jae Hyun Park - Princeton NJ, US
Minnie Park - Princeton Junction NJ, US
Bin Shao - Richboro PA, US
Laykea Tafesse - Robbinsville NJ, US
Jiangchao Yao - Princeton NJ, US
Mark A. Youngman - North Wales PA, US

International Classification:

C07D 239/42
C07D 403/12
C07D 401/04
C07D 413/04
C07D 401/12
C07D 471/08
C07D 401/14
C07D 405/14
C07D 487/08
C07D 403/14
C07D 413/14
C07D 403/04
C07D 405/12

Abstract:

The present disclosure provides substituted pyrimidine carboxamides of Formula (I) and the pharmaceutically acceptable salts and solvates thereof wherein A, X, A, W, W, W, E, Z, and Rare defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of sodium channels. Compounds of the present disclosure are especially useful for treating pain.