Bin B Shao

US Patent:

6867210, Mar 15, 2005

Filed:

Mar 12, 2001

Appl. No.:

09/803659

Inventors:

Derk J. Hogenkamp - Carlsbad CA, US
Phong Nguyen - Placentia CA, US
Bin Shao - Richboro PA, US

Assignee:

Euro-Celtique S.A. - Luxembourg

International Classification:

C07D239/46
C07D239/48
A61K031/505
A61K031/506
A61P025/08

US Classification:

514256, 544298, 544315, 544316, 544317, 544319, 544204, 544213, 544217, 544218, 544336, 544408, 514241, 5142521, 514277, 546290, 546296, 546297

Abstract:

This invention relates aryl substituted pyridines, pyrimidines, pyrazines and triazines of Formula I: or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein A, A, A, R-R, X and Y are set in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.

US Patent:

7105549, Sep 12, 2006

Filed:

Sep 6, 2002

Appl. No.:

10/235673

Inventors:

Bin Shao - Richboro PA, US
R. Richard Goehring - Pipersville PA, US
Samuel F Victory - Newtown PA, US
Qun Sun - Princeton NJ, US

Assignee:

Euro-Celtique S.A. - Luxembourg

International Classification:

A61K 31/443
A61K 31/4439
A61K 31/451
C07D 213/60
C07D 401/04
C07D 405/04
C07D 413/04

US Classification:

514341, 514343, 514345, 514352, 514354, 514357, 5462721, 5462724, 5462727, 5462754, 546290, 546304, 546313, 546314, 546329, 546339

Abstract:

This invention relates aryl substituted pyridines of Formula I:.

US Patent:

7456198, Nov 25, 2008

Filed:

Dec 6, 2000

Appl. No.:

09/730934

Inventors:

Donald Kyle - Newtown PA, US
R. Richard Goehring - Pipersville PA, US
Bin Shao - Richboro PA, US

Assignee:

Purdue Pharma L.P. - Stamford CT

International Classification:

A61K 31/44
C07D 211/32

US Classification:

514322, 546199

Abstract:

Disclosed are compounds of the formula (I).

US Patent:

7579367, Aug 25, 2009

Filed:

Sep 11, 2006

Appl. No.:

11/518448

Inventors:

Bin Shao - Richboro PA, US
R. Richard Goehring - Pipersville PA, US
Samuel F. Victory - Oak Ridge NC, US

Assignee:

Purdue Pharma L.P. - Stamford CT

International Classification:

A61K 31/4418
C07D 213/26

US Classification:

514355, 546339

Abstract:

This invention relates aryl substituted pyridines of Formula I:.

US Patent:

7678809, Mar 16, 2010

Filed:

Jul 28, 2006

Appl. No.:

11/494826

Inventors:

Donald Kyle - Newtown PA, US
Richard R. Goehring - Pipersville PA, US
Bin Shao - Richboro PA, US

Assignee:

Purdue Pharma L.P. - Stamford CT

International Classification:

A61K 31/44

US Classification:

514300

Abstract:

Disclosed are compounds of the formula (I).

US Patent:

7943643, May 17, 2011

Filed:

Aug 24, 2009

Appl. No.:

12/546572

Inventors:

Bin Shao - Richboro PA, US
R. Richard Goehring - Pipersville PA, US
Samuel F. Victory - Newtown PA, US

Assignee:

Purdue Pharma L.P. - Stamford CT

International Classification:

A61K 31/4418
C07D 213/26

US Classification:

514355, 546339

Abstract:

This invention relates aryl substituted pyridines of Formula I:.

US Patent:

8084612, Dec 27, 2011

Filed:

Jan 8, 2009

Appl. No.:

12/350450

Inventors:

Bin Shao - Richboro PA, US
Jiangchao Yao - Monmouth Junction NJ, US

Assignee:

Purdue Pharma L.P. - Stamford CT

International Classification:

C07D 409/12

US Classification:

546202, 548525

Abstract:

The invention relates to compounds of Formulae I(a) to XI.

US Patent:

8247442, Aug 21, 2012

Filed:

Mar 29, 2007

Appl. No.:

12/225743

Inventors:

Zhengming Chen - Belle Mead NJ, US
Khondaker Islam - Groton CT, US
Bin Shao - Richboro PA, US
Jiangchao Yao - Monmouth Junction NJ, US
Donald J. Kyle - Newtown PA, US

Assignee:

Purdue Pharma L.P. - Stamford CT

International Classification:

A61K 31/40
C07D 207/14

US Classification:

514426, 548557

Abstract:

The invention relates to azetidinyl, pyrrolidinyl, piperidinyl, and hexahydroazepinyl compounds of Formula I and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein R-Rand Z are defined as set forth in the specification. The invention is also directed to the use compounds of Formula I to treat, prevent or ameliorate a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.