Bin Huang Shao

US Patent:

7105549, Sep 12, 2006

Filed:

Sep 6, 2002

Appl. No.:

10/235673

Inventors:

Bin Shao - Richboro PA, US
R. Richard Goehring - Pipersville PA, US
Samuel F Victory - Newtown PA, US
Qun Sun - Princeton NJ, US

Assignee:

Euro-Celtique S.A. - Luxembourg

International Classification:

A61K 31/443
A61K 31/4439
A61K 31/451
C07D 213/60
C07D 401/04
C07D 405/04
C07D 413/04

US Classification:

514341, 514343, 514345, 514352, 514354, 514357, 5462721, 5462724, 5462727, 5462754, 546290, 546304, 546313, 546314, 546329, 546339

Abstract:

This invention relates aryl substituted pyridines of Formula I:.

US Patent:

7579367, Aug 25, 2009

Filed:

Sep 11, 2006

Appl. No.:

11/518448

Inventors:

Bin Shao - Richboro PA, US
R. Richard Goehring - Pipersville PA, US
Samuel F. Victory - Oak Ridge NC, US

Assignee:

Purdue Pharma L.P. - Stamford CT

International Classification:

A61K 31/4418
C07D 213/26

US Classification:

514355, 546339

Abstract:

This invention relates aryl substituted pyridines of Formula I:.

US Patent:

7943643, May 17, 2011

Filed:

Aug 24, 2009

Appl. No.:

12/546572

Inventors:

Bin Shao - Richboro PA, US
R. Richard Goehring - Pipersville PA, US
Samuel F. Victory - Newtown PA, US

Assignee:

Purdue Pharma L.P. - Stamford CT

International Classification:

A61K 31/4418
C07D 213/26

US Classification:

514355, 546339

Abstract:

This invention relates aryl substituted pyridines of Formula I:.

US Patent:

8084612, Dec 27, 2011

Filed:

Jan 8, 2009

Appl. No.:

12/350450

Inventors:

Bin Shao - Richboro PA, US
Jiangchao Yao - Monmouth Junction NJ, US

Assignee:

Purdue Pharma L.P. - Stamford CT

International Classification:

C07D 409/12

US Classification:

546202, 548525

Abstract:

The invention relates to compounds of Formulae I(a) to XI.

US Patent:

20030073724, Apr 17, 2003

Filed:

Sep 6, 2002

Appl. No.:

10/235670

Inventors:

Bin Shao - Richboro PA, US
R. Goehring - Pipersville PA, US

International Classification:

A61K031/44
C07D213/63

US Classification:

514/345000, 514/346000, 514/351000, 514/352000, 546/291000, 546/296000, 546/309000

Abstract:

This invention relates to aryl substituted pyridines of Formula I: or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Ar and R-Rare set in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, including diabetic neuropathy, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, and as antiarrhythmics.

US Patent:

20090298878, Dec 3, 2009

Filed:

Jul 12, 2007

Appl. No.:

12/373328

Inventors:

Akira Matsumura - Osaka, JP
Hidenori Mikamiyama - Osaka, JP
Naoki Tsuno - Osaka, JP
Donald J. Kyle - Newton PA, US
Bin Shao - Richboro PA, US
Jiangchao Yao - Monmouth NJ, US

International Classification:

A61K 31/445
C07D 211/98
G01N 23/00
C07D 401/12

US Classification:

514318, 546244, 514315, 436 57, 546194

Abstract:

The invention relates to oxime compounds of Formula (I) and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein X is hydrogen, optionally substituted aryl, optionally substituted heteroaryl or the like; Y is CO, SO, CRRor the like; Z is optionally substituted lower alkyl, optionally substituted aryl or the like; W is optionally substituted lower alkylene or optionally substituted lower alkenylene, Rand Rare each independently hydrogen, lower alkyl or the like; p is 0, 1, or 2 and q is 0, 1 or 2. The invention is also directed to the use compounds of Formula I to treat, prevent or ameliorate a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.

US Patent:

20090306136, Dec 10, 2009

Filed:

Apr 13, 2007

Appl. No.:

12/296788

Inventors:

Akira Matsumura - Osaka, JP
Hidenori Mikamiyama - Osaka, JP
Bin Shao - Richboro PA, US
Naoki Tsuno - Osaka, JP
Jiangchao Yao - Monmouth Junction NJ, US

International Classification:

A61K 31/4468
G01N 33/53
A61K 31/4545
A61K 31/454
C07D 401/06
C07D 211/56
A61P 25/00

US Classification:

514318, 436501, 514316, 514323, 514326, 514329, 546188, 546194, 546200, 546208, 546223

Abstract:

The invention relates to azetidinyl, pyrrolidinyl, piperidinyl, and hexahydroazepinyl compounds of Formula (I): and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein R-R, Z, p and q are defined as set forth in the specification. The invention is also directed to the use compounds of Formula (I) to treat, prevent or ameliorate a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.

US Patent:

20100216726, Aug 26, 2010

Filed:

Feb 24, 2010

Appl. No.:

12/712042

Inventors:

Kouki FUCHINO - Osaka, JP
R. Richard Goehring - Dublin PA, US
Akira Matsumura - Osaka, JP
Bin Shao - Richboro PA, US
Yoshiyuki Taoda - Osaka, JP
Naoki Tsuno - Osaka, JP
John William Frank Whitehead - Newtown PA, US
Jiangchao Yao - Princeton NJ, US

Assignee:

PURDUE PHARMA L.P. - Stamford CT
SHIONOGI & CO., LTD. - Osaka

International Classification:

A61K 38/05
C07D 401/04
A61K 31/498
A61P 3/04
A61P 13/06
A61P 9/12
A61P 25/08
A61P 25/16
A61P 25/22
A61P 25/24
A61P 25/28
A61P 25/30
A61P 1/12
C07D 413/14
A61K 31/5377
C07D 471/04
C07D 491/113
C07D 451/14

US Classification:

514 19, 544354, 514249, 544116, 5142348, 544350, 544230, 546112

Abstract:

The invention relates to Substituted-Quinoxaline-Type Piperidine Compounds, compositions comprising an effective amount of a Substituted-Quinoxaline-Type Piperidine Compound and methods to treat or prevent a condition, such as pain, comprising administering to an animal in need thereof an effective amount of a Substituted-Quinoxaline-Type Piperidine Compound.