Bing Hwei Wang

US Patent:

6608196, Aug 19, 2003

Filed:

May 3, 2002

Appl. No.:

10/138032

Inventors:

Bing Wang - Cupertino CA
Satyanarayana Janagani - Santa Clara CA
Wyeth B. Callaway - Austin TX
Jonathan L. Sessler - Austin TX

Assignee:

Galileo Pharmaceuticals, Inc. - Santa Clara CA

International Classification:

C07D41300

US Classification:

544130, 544162, 544171, 544365, 544399, 546208, 546226, 546242, 546246, 548569, 560 17, 560168, 562440, 564162, 564163, 564194

Abstract:

Provided are processes for synthesizing structurally diverse pyruvate-derived compounds using a parallel approach on a solid phase support. Examples of such a solid phase support include resins which have also been used in solid phase peptide synthesis.

US Patent:

6653346, Nov 25, 2003

Filed:

Feb 6, 2003

Appl. No.:

10/361141

Inventors:

Bing Wang - Cupertino CA
Jian Chen - Sunnyvale CA

Assignee:

Galileo Pharmaceuticals, Inc. - Santa Clara CA

International Classification:

A61K 3134

US Classification:

514469, 514468, 549469, 549468, 549460

Abstract:

Cytoprotective compounds, many of which are benzofuran derivatives are useful in the treatment of certain ischemic or inflammatory conditions, including but not limited to stroke, myocardial infarction, congestive heart failure, and skin disorders characterized by inflammation or oxidative damage. They are also useful in the manufacture of pharmaceutical and cosmetic formulations for the treatment of such conditions.

US Patent:

6667330, Dec 23, 2003

Filed:

Jan 28, 2003

Appl. No.:

10/354474

Inventors:

Bing Wang - Cupertino CA
Wei Zhang - Santa Clara CA
Jiangao Song - Cupertino CA
Ughetta del Balzo - Morgan Hill CA
Lesley Brown - East Palo Alto CA
Gail Walkinshaw - San Jose CA

Assignee:

Galileo Pharmaceuticals, Inc. - Santa Clara CA

International Classification:

A61K 31425

US Classification:

514367, 514383, 514473, 514256, 548156, 5482624, 549313, 544296

Abstract:

Furanone derivatives and the pharmaceutically acceptable salts thereof have cytoprotective activity and protective activity for neuroinflammation, and neurodegenerative disorders; they are useful in the treatment of stroke, cerebral ischemia, myocardial infarction, myocardial ischemia, chronic heart failure, inflammation and other oxidative stress-related conditions, as well as Alzheimers disease and senile dementia; they are also useful in the manufacture of pharmaceutical formulations for the treatment of such conditions.

US Patent:

6900218, May 31, 2005

Filed:

May 3, 2002

Appl. No.:

10/138938

Inventors:

Bing Wang - Cupertino CA, US
Guy Miller - San Jose CA, US
Satyanarayana Janagani - Santa Clara CA, US

Assignee:

Galileo Pharmaceuticals, Inc. - Santa Clara CA

International Classification:

C07D235/12
C07D239/74
C07D277/60
A61K031/428
A61K031/517

US Classification:

5142661, 514359, 514367, 514394, 544283, 544106, 548121, 548146, 548180, 5483101, 548165, 548182, 5483164

Abstract:

Certain known and novel pyruvate derivatives are particularly active in restoring or preserving metabolic integrity in oxidatively competent cells that have been subjected to oxygen deprivation. These pyruvate-derived compounds include, but are not limited to oximes, amides, pyruvate analogues, modified pyruvate analogues, esters of pyruvate (e. g. , polyol-pyruvate esters, pyruvate thioesters, glycerol-pyruvate esters and dihydroxyacetone-pyruvate esters). Such pyruvate derivatives (including single tautomers, single stereoisomers and mixtures of tautomers and/or stereoisomers, and the pharmaceutically acceptable salts thereof) are useful in the manufacture of pharmaceutical compositions for treating a number of conditions characterized by oxidative stress.

US Patent:

6912486, Jun 28, 2005

Filed:

Jun 17, 2003

Appl. No.:

10/464359

Inventors:

Bing Wang - San Jose CA, US

Assignee:

Nokia Inc. - Irving TX

International Classification:

G06F019/00

US Classification:

702188, 707205

Abstract:

The present invention provides a system and method for monitoring network appliances using formatted data files. A system for monitoring a network appliance by recording operational data in formatted data files includes a data management module and a data presentation module. The data management module is configured to determine selected operational data associated with the network appliance and to record the selected operational data in formatted data files. The selected operational data are a subset of data regarding transactions performed by the network appliance. The data management module is also configured to record the selected operational data with minimum processing. The data presentation module is configured to present statistical data. The statistical data is determined from the selected operational data in the formatted data files. The data presentation module is also configured to provide the statistical data in real-time.

US Patent:

6916850, Jul 12, 2005

Filed:

May 3, 2002

Appl. No.:

10/138937

Inventors:

Bing Wang - Cupertino CA, US
Guy Miller - San Jose CA, US
Wei Zhang - Santa Clara CA, US

Assignee:

Galileo Pharmaceuticals, Inc. - Santa Clara CA

International Classification:

C07C317/04
C07C321/14
A61K031/10
A61P009/10

US Classification:

514550, 560150, 560152, 560153, 562556

Abstract:

Certain known and novel pyruvate derivatives are particularly active in restoring or preserving metabolic integrity in oxidatively competent cells that have been subjected to oxygen deprivation. These pyruvate-derived compounds include, but are not limited to oximes, amides, pyruvate analogues, modified pyruvate analogues, esters of pyruvate (e. g. , polyol-pyruvate esters, pyruvate thioesters, glycerol-pyruvate esters and dihydroxyacetone-pyruvate esters). Such pyruvate derivatives (including single tautomers, single stereoisomers and mixtures of tautomers and/or stereoisomers, and the pharmaceutically acceptable salts thereof) are useful in the manufacture of pharmaceutical compositions for treating a number of conditions characterized by oxidative stress.

US Patent:

7034054, Apr 25, 2006

Filed:

Dec 14, 2001

Appl. No.:

10/020450

Inventors:

Guy Miller - San Jose CA, US
Lesley A. Brown - Reno NV, US
Ughetta Del Balzo - San Jose CA, US
Stephen Flaim - San Diego CA, US
Sekhar Boddupalli - San Jose CA, US
Bing Wang - Cupertino CA, US

Assignee:

Galileo Pharmaceuticals, Inc. - Santa Clara CA

International Classification:

A61K 31/355

US Classification:

514458

Abstract:

The present invention provides method for the treatment of a symptom of neuronal damage associated with cerebral ischemia comprising administering gamma-, beta-, or delta-tocopherol enriched tocopherol compositions.

US Patent:

7078541, Jul 18, 2006

Filed:

Sep 17, 2003

Appl. No.:

10/667280

Inventors:

Sekhar Boddupalli - San Jose CA, US
Gail Walkinshaw - San Jose CA, US
Bing Wang - Cupertino CA, US

Assignee:

Galileo Pharmaceuticals, Inc. - Santa Clara CA

International Classification:

C07D 307/78
A61K 31/36

US Classification:

549468, 549469, 549471, 514465

Abstract:

Certain benzofuran derivatives are useful in the treatment of certain ischemic or inflammatory conditions, as well as neuroinflammation, neurodegeneration or degenerative diseases in which mitochondrial dysfunction leads to tissue degeneration. They are also useful in the manufacture of pharmaceutical formulations for the treatment of such conditions.