The invention relates to compounds of formula (I):where A is an optionally substituted heteroaryl, useful for treating disorders mediated by acyl coA-diacylglycerol acyl transferase 1 (DGAT1), e.g. metabolic disorders. The invention also provides methods of treating such disorders, and compounds and compositions etc. for their treatment.
- Cambridge MA, US Cassandra CELATKA - Hull MA, US Seng CHENG - Natick MA, US Mary A. CROMWELL - Groton MA, US Andrew GOOD - Wallingford CT, US Bradford HIRTH - Framingham MA, US Katherine JANCSICS - Wilmington MA, US John P. LEONARD - Manchester NH, US Lingyun LI - Waltham MA, US James LILLIE - Wellesley MA, US Hanlan LIU - Lexington MA, US Elina MAKINO - Winchester MA, US John MARSHALL - Hopedale MA, US Paul MASON - Natick MA, US Markus METZ - Waltham MA, US Fazeela MORSHED - Waltham MA, US Thomas O'SHEA - Wellesley MA, US Ronald SCHEULE - Hopkinton MA, US Renato SKERLJ - West Newton MA, US Bing WANG - Newton MA, US Yibin XIANG - Dracut MA, US Zhong ZHAO - Wayland MA, US
The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.
- Cambridge MA, US Cassandra CELATKA - Hull MA, US Seng CHENG - Natick MA, US Mary A. CROMWELL - Groton MA, US Andrew GOOD - Wallingford CT, US Bradford HIRTH - Framingham MA, US Katherine JANCSICS - Wilmington MA, US John P. LEONARD - Manchester NH, US Lingyun LI - Waltham MA, US James LILLIE - Wellesley MA, US Hanlan LIU - Lexington MA, US Elina MAKINO - Winchester MA, US John MARSHALL - Hopedale MA, US Paul MASON - Natick MA, US Markus METZ - Waltham MA, US Fazeela MORSHED - Waltham MA, US Thomas O'SHEA - Wellesley MA, US Ronald SCHEULE - Hopkinton MA, US Renato SKERLJ - West Newton MA, US Bing WANG - Newton MA, US Yibin XIANG - Dracut MA, US Zhong ZHAO - Wayland MA, US
The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.
- Cambridge MA, US Cassandra CELATKA - Hull MA, US Seng CHENG - Natick MA, US Mary A. CROMWELL - Groton MA, US Andrew GOOD - Wallingford CT, US Bradford HIRTH - Framingham MA, US Katherine JANCSICS - Wilmington MA, US John P. LEONARD - Manchester NH, US Lingyun LI - Waltham MA, US James LILLIE - Wellesley MA, US Hanlan LIU - Lexington MA, US Elina MAKINO - Winchester MA, US John MARSHALL - Hopedale MA, US Paul MASON - Natick MA, US Markus METZ - Waltham MA, US Fazeela MORSHED - Waltham MA, US Thomas O'SHEA - Wellesley MA, US Ronald SCHEULE - Hopkinton MA, US Renato SKERLJ - West Newton MA, US Bing WANG - Newton MA, US Yibin XIANG - Dracut MA, US Zhong ZHAO - Wayland MA, US
The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.
Pathology Lab, NIH Perinatology Research Branch / Wayne State University
Dec 2007 to 2000 Research AssociateDepartment of Ob/Gyn, College of Medicine and Public Health, The Ohio State University Columbus, OH Jan 2005 to Dec 2007 Research AssociateDepartment of Ob/GynDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School Boston, MA Dec 2003 to Jan 2005 Postdoctoral fellowDepartment of Medicine, University of California, San Francisco (UCSF). San Francisco, CA Nov 2002 to Dec 2003 Postdoctoral fellowDivision of Oncology, Changzheng Hospital, Second Military Medical University.
Jul 1996 to Nov 2002 Attending PhysicianDivision of Cardiovascular Medicine, Changzheng Hospital, Second Military Medical University.
Aug 1990 to Aug 1993 Resident
Education:
Second Military Medical University Jan 1993 to Jan 1996 Ph.D. in Molecular CardiologySecond Military Medical University Jan 1984 to Jan 1990 M.D. in Medicine
Skills:
Cancer research especially anti-angiogenesis
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Bing Wang
Work:
George Washington University - Research Scientist (2012) University of Maryland - Research Associate (2011-2012)
Education:
Iowa State University
Bing Wang
Education:
State University of New York at Stony Brook - AMS, Zhejiang University - Mathematics and Applied Mathematics
Bing Wang
Education:
New York University - Dentistry, University of Toronto - Life Science
Bing Wang
Education:
THU - EE
Bing Wang
Education:
Stony Brook University - COMPUTER SCIENCE
Bing Wang
Work:
Fairchild Semiconductor International, Inc. - Test Engineer