Bing H Wang

US Patent:

7829063, Nov 9, 2010

Filed:

Apr 7, 2008

Appl. No.:

12/099135

Inventors:

Hartmuth C. Kolb - Playa Del Rey CA, US
Joseph C. Walsh - Pacific Palisades CA, US
Dhanalakshmi Kasi - Los Angeles CA, US
Vani P. Mocharla - Los Angeles CA, US
Bing Wang - San Jose CA, US
Umesh B. Gangadharmath - Los Angeles CA, US
Brian A. Duclos - Kalamazoo MI, US
Kai Chen - Los Angeles CA, US
Wei Zhang - Los Angeles CA, US
Gang Chen - Los Angeles CA, US
Henry Clifton Padgett - Hermosa Beach CA, US
Farhad Karimi - Canton MA, US
Peter J. H. Scott - Marina-del-Ray CA, US
Zhiyong Gao - Los Angeles CA, US
Qianwa Liang - Hacienda Heights CA, US
Thomas Lee Collier - Perkasie PA, US
Tieming Zhao - Los Angeles CA, US
Chunfang Xia - Los Angeles CA, US

Assignee:

Siemens Medical Solutions USA, Inc. - Malvern PA

International Classification:

A61K 51/00
C07D 343/00

US Classification:

424 111, 549 32

Abstract:

The present application discloses methods for identifying inhibitors with high binding-affinity for the carbonic anhydrase-IX (CA-IX) enzyme using click chemistry and uses the candidates thereof as positron emission tomography (PET) imaging agents.

US Patent:

8354092, Jan 15, 2013

Filed:

Aug 25, 2010

Appl. No.:

12/862955

Inventors:

Hartmuth C. Kolb - Playa Del Rey CA, US
Joseph C. Walsh - Pacific Palisades CA, US
Dhanalakshmi Kasi - Los Angeles CA, US
Vani P. Mocharla - Los Angeles CA, US
Bing Wang - San Jose CA, US
Umesh B. Gangadharmath - Los Angeles CA, US
Brian A. Duclos - Kalamazoo MI, US
Kai Chen - Rockville MD, US
Wei Zhang - Norwood MA, US
Gang Chen - Los Angeles CA, US
Henry Clifton Padgett - Hermosa Beach CA, US
Farhad Karimi - Mansfield MA, US
Peter J. H. Scott - Ypsilanti MI, US
Zhiyong Gao - Wynnewood PA, US
Qianwa Liang - Hacienda Heights CA, US
Thomas Lee Collier - Perkasie PA, US
Tieming Zhao - Los Angeles CA, US
Chunfang Xia - Los Angeles CA, US

Assignee:

Siemens Medical Solutions USA, Inc. - Malvern PA

International Classification:

A61K 51/00
C07D 249/00
C07D 343/00

US Classification:

424 153, 514359, 514449, 514461, 530330, 548255, 549429

Abstract:

The present application discloses methods for identifying inhibitors with high binding-affinity for the carbonic anhydrase-IX (CA-IX) enzyme using click chemistry and uses the candidates thereof as positron emission tomography (PET) imaging agents.

US Patent:

20080213175, Sep 4, 2008

Filed:

Sep 17, 2007

Appl. No.:

11/901704

Inventors:

Hartmuth C. Kolb - Playa Del Rey CA, US
Kai Chen - Los Angeles CA, US
Joseph C. Walsh - Pacific Palisades CA, US
Umesh Gangadharmath - Los Angeles CA, US
Dhanalakshmi Kasi - Los Angeles CA, US
Bing Wang - San Jose CA, US
Brian Duclos - Los Angeles CA, US
Qianwa Liang - Hacienda Heights CA, US
Henry Clifton Padgett - Hermosa Beach CA, US
Farhad Karimi - Canton MA, US

International Classification:

A61K 51/08
C07K 5/12
A61K 38/12
A61K 38/14

US Classification:

424 169, 530317, 514 11, 514 10, 514 8

Abstract:

The present application is directed to radiolabeled cyclic peptidomimetics, pharmaceutical compositions comprising radiolabeled cyclic peptidomimetics, and methods of using the radiolabeled cyclic peptidomimetics. Such peptidomimetics can be used in imaging studies, such as Positron Emitting Tomography (PET) or Single Photon Emission Computed Tomography (SPECT).

US Patent:

20140276674, Sep 18, 2014

Filed:

Mar 5, 2014

Appl. No.:

14/198394

Inventors:

- Santa Ana CA, US
Peter Patrick De Guzman - Orange CA, US
Victor Kardos - Irvine CA, US
Hong Fu - Pleasanton CA, US
Robert G. Heitel - Laguna Beach CA, US
John M. Tamkin - San Marino CA, US
Mikhail Levin - Santa ana CA, US
Bing Wang - Corona CA, US

International Classification:

A61F 9/008

US Classification:

606 4

Abstract:

A system and method for performing ophthalmic surgery using an ultra-short pulsed laser is provided. The system includes a laser engine configured to provide an ultra-short pulsed laser beam, optics configured to direct the laser beam to an undocked eye of a patient, an eye tracker configured to measure five degrees of freedom of movement of the undocked eye, an optical coherence tomography module configured to measure depth of the undocked eye, and a controller configured to control laser beam position on the undocked eye toward a desired laser pattern based on depth and the five degrees of freedom of movement of the undocked eye. Adaptive optics are also provided. Also disclosed are a scleral ring including fiducial markings and a compliant contact lens and fluid fillable contact lens configured to facilitate ultra-short pulsed laser surgery while reducing or eliminating eye docking requirements.