Bo Henrik Arve from 17725 Wilding Place Dr, Wildwood, MO 63005, age 67, Phone: (919)6076218

Resumes

Executive Director

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Location:

Chesterfield, MO

Industry:

Biotechnology

Work:

Pfizer since 2009
Executive Director
Wyeth Nov 1999 - 2009
Sr. Director, Process Development
Bayer 1997 - 1999
Principal Research Scientist
Chiron Corp 1990 - 1997
Principal Research Scientist
Pharmacia BioTech 1987 - 1990
Chromatography Specialist

Education:

University of Missouri-Rolla 1983 - 1986
Ph.D, Chemical Engineering KTH Royal Institute of Technology 1979 - 1983
BS, Chemical Engineering

Us Patents

Formulation, Solubilization, Purification, And Refolding Of Tissue Factor Pathway Inhibitor
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US Patent:

7022672, Apr 4, 2006
Filed:

Nov 30, 2001
Appl. No.:

09/996588
Inventors:

Glenn J. Dorin - San Rafael CA, US
Bo H. Arve - Cary NC, US
Gregory L. Pattison - Oakland CA, US
Robert F. Halenbeck - San Rafael CA, US
Kirk Johnson - Moraga CA, US
Bao-Lu Chen - San Ramon CA, US
Maninder S. Hoba - Danville CA, US
Hassan Madani - Seattle WA, US
Michael Tsang - San Francisco CA, US
Mark E. Gustafson - St. Charles MI, US
Gary S. Bild - Chesterfield MI, US
Gary V. Johnson - St. Charles MI, US
Assignee:

Chiron Corporation - Emeryville CA
G. D. Searle, LLC - St. Louis MO
International Classification:

A61K 38/00
C07K 14/00
US Classification:

514 12, 514 2, 514 8, 514 21, 514970, 514973, 530350, 530395
Abstract:

A method of modifying protein solubility employs polyionic polymers. These facilitate the solubilization, formulation, purification and refolding of proteins especially incorrectly folded proteins and aggregated proteins. Compositions are described that are suitable for formulating TFPI. The compositions allow preparation of pharmaceutically acceptable compositions of TFPI at concentrations above 0. 2 mg/mL and above 10 mg/mL.

Formulation, Solubilization, Purification, And Refolding Of Tissue Factor Pathway Inhibitor
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US Patent:

7226757, Jun 5, 2007
Filed:

Jan 24, 2006
Appl. No.:

11/337518
Inventors:

Glenn J. Dorin - San Rafeal CA, US
Bo H. Arve - Cary NC, US
Gregory L. Pattison - Oakland CA, US
Robert F. Halenbeck - San Rafeal CA, US
Kirk Johnson - Moraga CA, US
Bao-Lu Chen - San Ramon CA, US
Maninder S. Hora - Danville CA, US
Hassan Madani - Seattle WA, US
Michael Tsang - San Francisco CA, US
Mark E. Gustafson - St. Charles MI, US
Gary S. Bild - Chesterfield MI, US
Gary V. Johnson - St. Charles MI, US
Assignee:

G.D. Searle LLC - New York NY
Novartis Vaccines and Diagnostics, Inc. - Emeryville CA
International Classification:

C12P 21/02
C07K 1/18
C07K 1/20
US Classification:

435 691, 530416, 530412
Abstract:

Compositions are described that are suitable for formulating TFPI. Solubilizers and stabilizers facilitate the preparation of pharmaceutically acceptable compositions of TFPI at various concentrations.

Formulation, Solubilization, Purification, And Refolding Of Tissue Factor Pathway Inhibitor
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US Patent:

20080281084, Nov 13, 2008
Filed:

Apr 5, 2007
Appl. No.:

11/697188
Inventors:

Glenn J. Dorin - San Rafael CA, US
Bo H. Arve - Cary NC, US
Gregory L. Pattison - Oakland CA, US
Robert F. Halenbeck - San Rafael CA, US
Kirk Johnson - Moraga CA, US
Bao-Lu Chen - San Ramon CA, US
Maninder S. Hora - Danville CA, US
Hassan Madani - Seattle WA, US
Michael Tsang - San Francisco CA, US
Mark E. Gustafson - St. Charles MI, US
Gary S. Bild - Chesterfield MI, US
Gary V. Johnson - St. Charles MI, US
Assignee:

Novartis Vaccines and Diagnostics, Inc. - Emeryville CA
G. D. Searle LLC - New York NY
International Classification:

C07K 14/47
US Classification:

530395
Abstract:

Compositions are described that are suitable for formulating TFPI. Solubilizers and stabilizers facilitate the preparation of pharmaceutically acceptable compositions of TFPI at various concentrations.

Method Of Solubilizing, Purifying, And Refolding Protein
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US Patent:

63233266, Nov 27, 2001
Filed:

Jun 11, 1999
Appl. No.:

8/973211
Inventors:

Glenn J. Dorin - San Rafael CA
Bo H. Arve - Cary NC
Gregory L. Pattison - Oakland CA
Robert F Halenbeck - San Rafael CA
Kirk Johnson - Moraga CA
Bao-Lu Chen - San Ramon CA
Maninder S. Hoba - Danville CA
Hassan Madani - Seattle WA
Michael Tsang - San Francisco CA
Mark E. Gustafson - St. Charles MO
Gary S. Bild - Chesterfield MO
Gary V. Johnson - Charles MO
Assignee:

Chiron Corporation - Emeryville CA
G. D. Searle & Co. - Skokie IL
International Classification:

A23J 100
US Classification:

530412
Abstract:

A method of modifying protein solubility employs polyionic polymers. These facilitate the solubilization, formulation, purification and refolding of proteins especially incorrectly folded proteins and aggregated proteins. Compositions are described that are suitable for formulating TFPI. The compositions allow preparation of pharmaceutically acceptable compositions of TFPI at concentrations above 0. 2 mg/mL and above 10 mg/mL.

Method Of Solubilizing, Purifying, And Refolding Protein
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US Patent:

63198967, Nov 20, 2001
Filed:

Nov 18, 1999
Appl. No.:

9/443098
Inventors:

Glenn J. Dorin - San Rafael CA
Bo H. Arve - Cary NC
Gregory L. Pattison - Oakland CA
Robert F. Halenbeck - San Rafael CA
Kirk Johnson - Moraga CA
Bao-Lu Chen - San Ramon CA
Maninder S. Hora - Danville CA
Hassan Madani - Seattle WA
Michael Tsang - San Francisco CA
Mark E. Gustafson - St. Charles MO
Gary S. Bild - Chesterfield MO
Gary V. Johnson - Charles MO
Assignee:

Chiron Corporation - Emeryville CA
G.D. Searle & Co. - Skokie IL
International Classification:

A61K 3816
A01N 3718
US Classification:

514 8
Abstract:

A method of modifying protein solubility employs polyionic polymers. These facilitate the solubilization, formulation, purification and refolding of proteins especially incorrectly folded proteins and aggregated proteins. Compositions are described that are suitable for formulating TFPI. The compositions allow preparation of pharmaceutically acceptable compositions of TFPI at concentrations above 0. 2 mg/mL and above 10 mg/mL.