Bradley D Johnson

US Patent:

6465513, Oct 15, 2002

Filed:

Jan 21, 2000

Appl. No.:

09/489157

Inventors:

Francine S. Grant - Milpitas CA
Bradley S. Johnson - San Francisco CA
Michael A. Pleiss - Sunnyvale CA
Eugene D. Thorsett - Half Moon Bay CA

Assignee:

Elan Pharmaceuticals, Inc. - South San Francisco CA

International Classification:

A01N 3700

US Classification:

514529, 514 18, 514 19, 514260, 562507

Abstract:

Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e. g. , human, such as asthma, Alzheimers disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.

US Patent:

7115768, Oct 3, 2006

Filed:

Sep 16, 2002

Appl. No.:

10/243731

Inventors:

Francine S. Grant - Milpitas CA, US
Bradley S. Johnson - San Francisco CA, US
Michael A. Pleiss - Sunnyvale CA, US
Eugene D. Thorsett - Half Moon Bay CA, US

Assignee:

Elan Pharmaceuticals, Inc. - South San Francisco CA

International Classification:

C07C 69/00

US Classification:

560129, 546133, 514529, 514507

Abstract:

Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e. g. , human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.

US Patent:

7474965, Jan 6, 2009

Filed:

Apr 5, 2005

Appl. No.:

11/099326

Inventors:

Bradley Johnson - Berkeley CA, US
Rehan M. Khan - Berkeley CA, US
Noam Sobel - Berkeley CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

G06F 19/00

US Classification:

702 22, 702 24, 702 27, 73 2504, 73 2901, 73 2327

Abstract:

A system and method for identifying molecules. Molecules are identified from a gaseous matter having the molecules and flowing at two different flow rates. A system and method for identifying a substance. A particle which is indicative of a substance is identified from matter having the particle and flowing at two different flow rates. After the particle is identified, the substance is identified.

US Patent:

7948041, May 24, 2011

Filed:

Oct 25, 2007

Appl. No.:

11/924328

Inventors:

Craig Bryant - Alameda CA, US
Jean-Christophe P. Gabriel - Quaix en Chartreuse, FR
Bradley N. Johnson - Berkeley CA, US
Oleksandr Kuzmych - Emeryville CA, US
William Mickelson - San Francisco CA, US
John Loren Passmore - Berkeley CA, US
Christian Valcke - Orinda CA, US

Assignee:

Nanomix, Inc. - Emeryville CA

International Classification:

H01L 27/14

US Classification:

257414, 257E31119, 257E3306

Abstract:

Sensors and detection systems suitable for measuring analytes, such as biomolecule, organic and inorganic species, including environmentally and medically relevant volatiles and gases, such as NO, NO2, CO2, NH3, H2, CO and the like, are provided. Certain embodiments of nanostructured sensor systems are configured for measurement of medically important gases in breath. Applications include the measurement of endogenous nitric oxide (NO) in breath, such as for the monitoring or diagnosis of asthma and other pulmonary conditions.

US Patent:

8152991, Apr 10, 2012

Filed:

Dec 8, 2006

Appl. No.:

11/636360

Inventors:

Mikhail Briman - Emeryville CA, US
Craig Bryant - Alameda CA, US
Jean-Christophe P. Gabriel - Pinole CA, US
Shirpal C. Gandhi - Los Angeles CA, US
Bradley N Johnson - Berkeley CA, US
Willem-Jan Ouborg - Moraga CA, US
John Loren Passmore - Berkeley CA, US
Alexander Star - Pittsburgh PA, US
Christian Valcke - Orinda CA, US

Assignee:

Nanomix, Inc. - Emeryville CA

International Classification:

G01N 27/26

US Classification:

205775, 205778, 205781, 205782, 2057825, 205783, 2057855, 205786, 205787, 205792, 2057945

Abstract:

Embodiments of nanoelectronic sensors are described, including sensors for detecting analytes such ammonia. An environmental control system employing nanoelectronic sensors is described. A personnel safety system configured as a disposable badge employing nanoelectronic sensors is described. A method of dynamic sampling and exposure of a sensor providing a number of operational advantages is described.

US Patent:

20090056419, Mar 5, 2009

Filed:

Aug 18, 2008

Appl. No.:

12/193353

Inventors:

Bradley N. JOHNSON - Berkeley CA, US
Craig BRYANT - Alameda CA, US
William MICKELSON - San Francisco CA, US

Assignee:

Nanomix, Inc. - Emeryville CA

International Classification:

G01N 33/00
B01J 19/00
B01J 8/06

US Classification:

73 3105, 422198, 422211

Abstract:

Provided herein are catalytic converters that have improved characteristics. According to various embodiments, the converters include high surface area catalyst supports conformally coated with nanoparticulate thin films of a catalyst (e.g., Pt, Pd and Rh). The films are continuous, preventing absorption of species within the converter on the catalyst support. The converters provide higher oxidation efficiency than conventional catalytic converters, in certain embodiments approaching the stoichiometric ratio for the reaction. The converters also provide minimal loss of chemical species within the converter. Also provided are novel methods of fabricating catalytic converters that involve atomic layer deposition of Pt or other catalyst on the support, as well as methods and devices for sensing NO in samples that involve catalytic conversion of NO to NO2.

US Patent:

20100268106, Oct 21, 2010

Filed:

Apr 15, 2010

Appl. No.:

12/761290

Inventors:

Bradley N. Johnson - Berkeley CA, US
Kanchan Joshi - Emeryville CA, US
Ray Radtkey - Oakland CA, US

Assignee:

Nanomix, Inc. - Emeryville CA

International Classification:

A61B 5/097

US Classification:

600532

Abstract:

The present invention provides a direct sampler and detector for analytes found in exhaled breath condensate. Analytes in the breath condensate are detected instantaneously as they condense prior to reaching the sensor surface or condense directly on the sensor surface. Because the analysis or assay is performed immediately after patient exhalation, analyte stability is significantly improved providing accurate, reliable, consistent, and clinically applicable results. In certain embodiments, combined breath condensate/breath samplers and detectors are provided, enabling multiplexed analysis of condensed and vapor-phase analytes provided in a single sampling session. Breath is collected and directed to one or more subsystems. Within each subsystem, the breath portion is either condensed or prevented from condensing. The technique also allows real-time continuous monitoring, thus allowing immediate feedback to both medical professionals and additional hardware such as ventilators, anesthesia machines, drug infusion systems and cardiac pacemakers.

US Patent:

20120006102, Jan 12, 2012

Filed:

Apr 11, 2011

Appl. No.:

13/084465

Inventors:

Craig Bryant - Alameda CA, US
Jean-Christophe P. Gabriel - Isere, FR
Bradley N. Johnson - Berkeley CA, US
Oleksandr Kuzmych - Emeryville CA, US
William Mickelson - San Francisco CA, US
John Loren Passmore - Berkeley CA, US
Christian Valcke - Orinda CA, US

Assignee:

NANOMIX, INC. - Emeryville CA

International Classification:

G01N 33/00
B82Y 15/00

US Classification:

73 6143, 977712

Abstract:

Sensors and detection systems suitable for measuring analytes, such as biomolecule, organic and inorganic species, including environmentally and medically relevant volatiles and gases, such as NO, NO2, CO2, NH3, H2, CO and the like, are provided. Certain embodiments of nanostructured sensor systems are configured for measurement of medically important gases in breath. Applications include the measurement of endogenous nitric oxide (NO) in breath, such as for the monitoring or diagnosis of asthma and other pulmonary conditions.