Braulio O Santiago

US Patent:

63293927, Dec 11, 2001

Filed:

May 15, 1998

Appl. No.:

9/079924

Inventors:

Timothy P. Burkholder - Carmel IN
Larry D. Bratton - Whitmore Lake MI
Elizabeth M. Kudlacz - Groton CT
George P. Maynard - Westbrook CT
John M. Kane - Cincinnati OH
Braulio Santiago - San Juan PR

Assignee:

Aventis Pharmaceuticals, Inc. - Bridgewater NJ

International Classification:

A61K 31445

US Classification:

514322

Abstract:

The present invention relates to novel substituted piperidine derivatives of the formula ##STR1## stereoisomers thereof, and pharmaceutically acceptable salts thereof which are useful as histamine receptor antagonists and tachykinin receptor antagonist. Such antagonists are useful in the treatment of allergic diseases including: seasonal rhinitis, allergic rhinitis, and sinusitis.

US Patent:

6211199, Apr 3, 2001

Filed:

Dec 15, 1997

Appl. No.:

9/513846

Inventors:

John M. Kane - Cincinnati OH
George D. Maynard - Westbrook CT
Timothy P. Burkholder - Carmel IN
Larry D. Bratton - Westminister CO
Christopher R. Dalton - Mundelein IL
Braulio Santiago - San Juan PR
Elizabeth M. Kudlacz - Groton CT

Assignee:

Aventis Pharmaceuticals Inc. - Bridgewater NJ

International Classification:

A61K 314523
C07D40112
C07D40114

US Classification:

514322

Abstract:

The present invention relates to novel substituted piperidine derivatives of formula (1), stereoisomers ##STR1## thereof, and pharmaceutically acceptable salts thereof which are useful as histamine receptor antagonists and tachykinin receptor antagonist. Such antagonists are useful in the treatment of allergic rhinitis, including seasonal rhinitis and sinusitis; inflammatory bowel diseases, including Crohn's disease and ulcerative colitis; asthma; bronchitis; and emesis.

US Patent:

59325712, Aug 3, 1999

Filed:

Mar 6, 1998

Appl. No.:

9/036155

Inventors:

George D. Maynard - Westbrook CT
John M. Kane - Cincinnati OH
Christopher R. Dalton - Mundelein IL
Braulio Santiago - San Juan PR
Elizabeth M. Kudlacz - Groton CT
Larry D. Bratton - Whitmore Lake MI

Assignee:

Hoechst Marion Roussel, Inc. - Bridgewater NJ

International Classification:

A61K 3155
C07D40314

US Classification:

514218

Abstract:

The present invention relates to novel N-methyl-N-(4-(4-(1H-benzimidazol-2-yl)�1,4!diazepan-1-yl)-2-(aryl)butyl)b enzamide derivatives of the formula: ##STR1## stereoisomers thereof, and pharmaceutically acceptable salts thereof which are useful as histamine receptor antagonists and tachykinin receptor antagonists. Such antagonists are useful in the treatment of allergic rhinitis, including seasonal rhinitis and sinusitis; inflammatory bowel diseases, including Crohn's disease and ulcerative colitis; asthma; bronchitis; and emesis.

US Patent:

61944068, Feb 27, 2001

Filed:

Oct 29, 1997

Appl. No.:

9/513847

Inventors:

John M. Kane - Cincinnati OH
George D. Maynard - Westbrook CT
Timothy P. Burkholder - Carmel IN
Larry D. Bratton - Whitmore Lake MI
Christopher R. Dalton - Mundelein IL
Elizabeth M. Kudlacz - Groton CT
Braulio Santiago - San Juan PR

Assignee:

Aventis Pharmaceuticals Inc. - Bridgewater NJ

International Classification:

A61K 31551
C07D43014

US Classification:

514218

Abstract:

The present invention relates to novel 4-(1H-benzimidazol-2-yl)[1,4]diazepane derivatives of formula (1): ##STR1## and stereoisomers thereof, and pharmaceutically acceptable salts thereof which are useful as histamine receptor antagonists and tachykinin receptor antagonist. Such antagonists are useful in the treatment of allergic rhinitis, including seasonal rhinitis and sinusitis; inflammatory bowel diseases, including Crohn's disease and ulcerative colitis; asthma; bronchitis; and emesis.