Brent Lee Atkinson

US Patent:

6482594, Nov 19, 2002

Filed:

Jun 14, 2001

Appl. No.:

09/882246

Inventors:

Larry Gold - Boulder CO
Michael Willis - Louisville CO
Tad Koch - Boulder CO
Steven Ringquist - Lyons CO
Kirk Jensen - Boulder CO
Brent Atkinson - Boulder CO

Assignee:

SomaLogic, Inc. - Boulder CO

International Classification:

C12Q 168

US Classification:

435 6, 435 912, 536 231, 536 2433, 536 254

Abstract:

Methods to obtain nucleic acid ligands that photocrosslink to target molecules associated with a disease state are provided. The methods presented are variations on the photoSELEX methods for obtaining nucleic acid ligands. In one method, a candidate mixture of photocrosslinkable nucleic acids is contacted with a biological substance obtained from a source associated with a disease state suspected of containing a target molecule to form nucleic acid-target molecule complexes, the complexes are irradiated to form crosslinked complexes, the photocrosslinked complexes are partitioned from the remainder of the candidate mixture; and the nucleic acid ligands that photocrosslink to molecule are retained. These nucleic acids are then contacted with a second biological substance of the same type as the first, but obtained from a source not associated with a disease state. This removes nucleic acids with affinity to molecules that are not associated with the disease state.

US Patent:

6511958, Jan 28, 2003

Filed:

Feb 16, 2000

Appl. No.:

09/505209

Inventors:

Brent Atkinson - Lakewood CO
James J. Benedict - Arvada CO

Assignee:

Sulzer Biologics, Inc. - Austin TX

International Classification:

A01N 3718

US Classification:

514 2, 514 21, 424422, 424423, 424484, 424549, 530350, 530840

Abstract:

Disclosed is a cartilage repair product that induces both cell ingrowth into a bioresorbable material and cell differentiation into cartilage tissue. Such a product is useful for regenerating and/or repairing both vascular and avascular cartilage lesions, particularly articular cartilage lesions, and even more particularly mensical tissue lesions, including tears as well as segmental defects. Also disclosed is a method of regenerating and repairing cartilage lesions using such a product.

US Patent:

6514514, Feb 4, 2003

Filed:

Feb 16, 1999

Appl. No.:

09/250370

Inventors:

Brent Atkinson - Lakewood CO
James J. Benedict - Arvada CO

Assignee:

Sùlzer Biologics Inc. - Austin TX

International Classification:

A61E 1300

US Classification:

424423, 424422, 424424, 424425, 424426, 424484, 424572, 514 2, 530350

Abstract:

Disclosed is a cartilage repair product that induces both cell ingrowth into a bioresorbable material and cell differentiation into cartilage tissue. Such a product is useful for regenerating and/or repairing both vascular and avascular cartilage lesions, particularly articular cartilage lesions, and even more particularly mensical tissue lesions, including tears as well as segmental defects. Also disclosed is a method of regenerating and repairing cartilage lesions using such a product.

US Patent:

6582471, Jun 24, 2003

Filed:

Sep 13, 2000

Appl. No.:

09/485594

Inventors:

Pedro Bittmann - Zürich, CH
Brent Atkinson - Lakewood CO
James J. Benedict - Golden CO
John Ranieri - Austin TX
Marsha L. Whitney - Austin TX
Donald Chickering - Framingham MA

Assignee:

Sulzer Innotec AG - Winterthur

International Classification:

A61F 236

US Classification:

623 2363, 623 2351

Abstract:

The composition as described serves for in vivo cartilage repair. It basically consists of a naturally derived osteoinductive and/or chondroinductive mixture of factors (e. g. derived from bone) or of a synthetic mimic of such a mixture combined with a nanosphere delivery system. A preferred mixture of factors is the combination of factors isolated from bone, known as BP and described by Poser and Benedict (WO 95/13767). The nanosphere delivery system consists of nanospheres defined as polymer particles of less than 1000 nm in diameter (whereby the majority of particles preferably ranges between 200-400 nm) in which nanospheres the combination of factors is encapsulated. The nanospheres are loaded with the mixture of factors in a weight ratio of 0. 001 to 17% (w/w), preferably of 1 to 4% (w/w) and have a release profile with an initial burst of 10 to 20% of the total load over the first 24 hours and a long time release of at least 0. 1 per day during at least seven following days.

US Patent:

RE41286, Apr 27, 2010

Filed:

Jan 28, 2005

Appl. No.:

11/046674

Inventors:

Brent Atkinson - Lakewood CO, US
James J. Benedict - Arvada CO, US

Assignee:

Zimmer Orthobiologics, Inc. - Austin TX

International Classification:

A01N 37/18
A61K 38/00
A61K 9/14
A61K 35/32
A61F 13/00
A61F 2/00
C07K 1/00
C07K 14/00
C07K 17/00

US Classification:

514 2, 424422, 424423, 424484, 424549, 514 21, 530350

Abstract:

Disclosed is a cartilage repair product that induces both cell ingrowth into a bioresorbable material and cell differentiation into cartilage tissue. Such a product is useful for regenerating and/or repairing both vascular and avascular cartilage lesions, particularly articular cartilage lesions, and even more particularly mensical tissue lesions, including tears as well as segmental defects. Also disclosed is a method of regenerating and repairing cartilage lesions using such a product.

US Patent:

7842300, Nov 30, 2010

Filed:

Jul 28, 2003

Appl. No.:

10/628692

Inventors:

Brent L. Atkinson - Lakewood CO, US
Tracey S. Hanks - Denver CO, US

Assignee:

DENTSPLY International, Inc. - York PA

International Classification:

A61L 24/00
A61L 27/46
A61L 27/56
A61L 27/58

US Classification:

424400, 424426, 424489

Abstract:

A bone repair material is described that is of putty-like consistency, particularly useful for repairing dental bony defects such as those caused by bone loss resulting from moderate or severe periodontitis, augmenting of bony defects of the alveolar ridge, filling tooth extraction sites, or sinus elevation grafting. The repair material includes a porous, resorbable particulate that is bone-derived or derived from bone-like hydroxyapatite or synthetic hydroxyapatite; and, a resorbable carrier, such as high molecular weight polysaccharides, such as hyaluronic acid. A high concentration of particulate in the putty enhances bone repair and requires a high concentration of carrier to retain the putty at the defect site. For a particulate density of about 1. 2 g/cc such as PEPGEN P-15 Bone Graft, a preferred formulation comprises about 55% percent by weight of the putty suspended in a hyaluronic acid gel of about 1.

US Patent:

7981862, Jul 19, 2011

Filed:

Jun 22, 2007

Appl. No.:

11/767391

Inventors:

Paul O. Zamora - Gaithersburg MD, US
Brent Lee Atkinson - Frederick MD, US

Assignee:

BioSurface Engineering Technologies, Inc. - Rockville MD

International Classification:

A61K 38/18
C07K 14/475
C07K 14/51
C07K 14/00
C07K 5/00

US Classification:

514 76, 514 88, 530300, 530402

Abstract:

A composition comprising a synthetic growth factor analogue comprising a non-growth factor heparin binding region, a linker and a sequence that binds specifically to a cell surface receptor and an osteoconductive material where the synthetic growth factor analogue is attached to and can be released from the osteoconductive material and is an amplifier/co-activator of osteoinduction.

US Patent:

20030236574, Dec 25, 2003

Filed:

Mar 11, 2003

Appl. No.:

10/386946

Inventors:

Pedro Bittman - Zurich, CH
Brent Atkinson - Lakewood CO, US
James Benedict - Golden CO, US
John Ranieri - Austin TX, US
Marsha Whitney - Austin TX, US
Donald Chickering - Framingham MA, US

Assignee:

Sulzer Innotec AG

International Classification:

A61F002/28

US Classification:

623/023630, 523/115000

Abstract:

The composition as described serves for in vivo cartilage repair. It basically consists of a naturally derived osteoinductive and/or chondroinductive mixture of factors (e.g. derived from bone) or of a synthetic mimic of such a mixture combined with a nanosphere delivery system. A preferred mixture of factors is the combination of factors isolated from bone, known as BP and described by Poser and Benedict (WO 95/13767). The nanosphere delivery system consists of nanospheres defined as polymer particles of less than 1000 nm in diameter (whereby the majority of particles preferably ranges between 200-400 nm) in which nanospheres the combination of factors is encapsulated. The nano-spheres are loaded with the mixture of factors in a weight ratio of 0.001 to 17% (w/w), preferably of 1 to 4% (w/w) and have a release profile with an initial burst of 10 to 20% of the total load over the first 24 hours and a long time release of at least 0.1 per day during at least seven following days. The nanospheres are composed of e.g. ((D,L)-lactic acid/glycolic acid)-copolymer (PLGA). The loaded nanospheres are e.g. made by phase inversion. The composition is advantageously utilized as a device comprising any biodegradable matrix in which the nanospheres loaded with the factor combination is contained.