Brett M Cook

US Patent:

20160199491, Jul 14, 2016

Filed:

Apr 15, 2015

Appl. No.:

14/545280

Inventors:

- Petaluma CA, US
Brett Michael Cook - Goleta CA, US
Matthew H. Lyttle - Sonoma CA, US

Assignee:

Biosearch Technologies, Inc. - Petaluma CA

International Classification:

A61K 41/00
A61K 31/7076
C07H 19/10
B01J 19/24
A61K 31/708
A61K 31/7072
C12N 15/113
C12P 19/34
C07H 19/20
A61K 31/7068

Abstract:

The present invention generally relates to compounds that include one or more thermally labile protecting groups, compositions including the compounds, methods of making the compounds and compositions and methods of using the compounds and compositions. In one aspect, the present invention is directed to a compound of the structure XO—CH—SM-B-A. The substituent X is H, an acid labile protecting group, a solid support, —P(O—R)NRR, —P(O)(OH)H, —P(O)(OR)H, —P(O)(OH), —P(O)(OH)O—P(O)(OH)OP(O)(OH)or salts thereof. The substituent Ris CNE (i.e., cyanoethyl), alkyl, or heteroalkyl and Rand Rare independently alkyl. The substituent SM is a sugar moiety or analogue thereof that is not a natural furanosyl, B is a base moiety or analogue thereof, and A is a moiety attached to a nitrogen on or in the base moiety of the structure —C(O)OR, wherein Ris tertiary alkyl.