Brian E Castle

US Patent:

20060019303, Jan 26, 2006

Filed:

Jul 22, 2005

Appl. No.:

11/187572

Inventors:

Brian Castle - Monroe CT, US
Jianfei Yang - Sandy Hook CT, US
Xiang Li - New Milford CT, US
Jun Li - Danbury CT, US

Assignee:

Boehringer Ingelheim Pharmaceuticals, Inc. - Ridgefield CT

International Classification:

C12Q 1/68

US Classification:

435006000

Abstract:

A method of identifying genes involved in the stimulation of primary T cells comprising the steps of: a) contacting experimental cells with a stimulating agent; b) preparing RNA from said experimental cells at one or more stimulation phases; c) measuring the level of gene expression in the cells; d) comparing the levels of gene expression of said experimental cells to the level of gene expression in control cells that have not been exposed to an stimulation agent; e) identifying genes that are up regulated or down regulated in said experimental cells relative to said control cells.

US Patent:

62970526, Oct 2, 2001

Filed:

Apr 24, 1997

Appl. No.:

8/858197

Inventors:

Marilyn Kehry - Danbury CT
Brian Castle - New Fairfield CT

Assignee:

Boehringer Ingelheim Pharmaceuticals, Inc. - Ridgefield CT

International Classification:

C12N 500
C12N 502
C07K 1452

US Classification:

435377

Abstract:

The present invention provides methods of proliferating B cells as a means of obtaining large numbers of B cells. The present invention further provides methods of differentiating a proliferating B cell population to antibody producing cells.

US Patent:

58175164, Oct 6, 1998

Filed:

Apr 28, 1995

Appl. No.:

8/431055

Inventors:

Marilyn Kehry - Danbury CT
Brian Castle - New Fairfield CT

Assignee:

Boehringer Ingelheim Pharmaceuticals, Inc. - Ridgefield CT

International Classification:

C12N 502
C12N 508

US Classification:

435377

Abstract:

The present invention provides methods of proliferating B cells as a means of obtaining large numbers of B cells. The present invention further provides methods of differentiating a proliferating B cell population to antibody producing cells.