Brian W Christman

US Patent:

6743823, Jun 1, 2004

Filed:

Jun 1, 2000

Appl. No.:

09/585077

Inventors:

Marshall L. Summar - Brentwood TN
Brian W. Christman - Nashville TN

Assignee:

Vanderbilt University - Nashville TN

International Classification:

A61K 31195

US Classification:

514565, 536 232, 536 235, 435 6, 435194

Abstract:

Isolated polynucleotide molecules and peptides encoded by these molecules are used in the analysis of human carbamyl phosphate synthetase I phenotypes, as well as in diagnostic and therapeutic applications, relating to a human carbamyl phosphate synthetase I polymorphism. By analyzing genomic DNA or amplified genomic DNA, or amplified cDNA derived from mRNA, it is possible to type a human carbamyl phosphate synthetase I with regard to the human carbamyl phosphate synthetase I polymorphism, for example, in the context of diagnosing and treating hepatic veno-occlusive disease (HVOD) associated with bone marrow transplants.

US Patent:

8188147, May 29, 2012

Filed:

May 16, 2008

Appl. No.:

12/122117

Inventors:

Marshall L. Summar - Brentwood TN, US
Brian W. Christman - Nashville TN, US
Frederick E. Barr - Nashville TN, US

Assignee:

Vanderbilt University - Nashville TN

International Classification:

A61K 31/195

US Classification:

514565

Abstract:

Isolated polynucleotide molecules and peptides encoded by these molecules are used in the analysis of human carbamyl phosphate synthetase I phenotypes, as well as in diagnostic and therapeutic applications, relating to a human carbamyl phosphate synthetase I polymorphism. By analyzing genomic DNA or amplified genomic DNA, or amplified cDNA derived from mRNA, it is possible to type a human carbamyl phosphate synthetase I with regard to the human carbamyl phosphate synthetase I polymorphism, for example, in the context of diagnosing and treating hepatic veno-occlusive disease (HVOD) associated with bone marrow transplants.

US Patent:

8536225, Sep 17, 2013

Filed:

Apr 25, 2012

Appl. No.:

13/456014

Inventors:

Marshall L. Summar - Brentwood TN, US
Brian W. Christman - Nashville TN, US
Frederick E. Barr - Nashville TN, US

Assignee:

Vanderbilt University - Nashville TN

International Classification:

A61K 31/195

US Classification:

514565

Abstract:

Isolated polynucleotide molecules and peptides encoded by these molecules are used in the analysis of human carbamyl phosphate synthetase I phenotypes, as well as in diagnostic and therapeutic applications, relating to a human carbamyl phosphate synthetase I polymorphism. By analyzing genomic DNA or amplified genomic DNA, or amplified cDNA derived from mRNA, it is possible to type a human carbamyl phosphate synthetase I with regard to the human carbamyl phosphate synthetase I polymorphism, for example, in the context of diagnosing and treating hepatic veno-occlusive disease (HVOD) associated with bone marrow transplants.

US Patent:

20040235953, Nov 25, 2004

Filed:

Feb 24, 2004

Appl. No.:

10/785374

Inventors:

Marshall Summar - Brentwood TN, US
Brian Christman - Nashville TN, US
Frederick Barr - Nashville TN, US

Assignee:

Vanderbilt University

International Classification:

A61K031/198

US Classification:

514/565000

Abstract:

Isolated polynucleotide molecules and peptides encoded by these molecules are used in the analysis of human carbamyl phosphate synthetase I phenotypes, as well as in diagnostic and therapeutic applications, relating to a human carbamyl phosphate synthetase I polymorphism. By analyzing genomic DNA or amplified genomic DNA, or amplified cDNA derived from mRNA, it is possible to type a human carbamyl phosphate synthetase I with regard to the human carbamyl phosphate synthetase I polymorphism, for example, in the context of diagnosing and treating hepatic veno-occlusive disease (HVOD) associated with bone marrow transplants.

US Patent:

6346382, Feb 12, 2002

Filed:

Jun 1, 1999

Appl. No.:

09/323472

Inventors:

Marshall L. Summar - Brentwood TN
Brian W. Christman - Nashville TN

Assignee:

Vanderbilt University - Nashville TN

International Classification:

C12Q 168

US Classification:

435 6, 435 912, 435 915, 536 232, 536 235, 536 2431, 536 2433, 536 2532

Abstract:

Isolated polynucleotide molecules and peptides encoded by these molecules are used in the analysis of human carbamyl phosphate synthetase I phenotypes, as well as in diagnostic and therapeutic applications, relating to a human carbamyl phosphate synthetase I polymorphism. By analyzing genomic DNA or amplified genomic DNA, or amplified cDNA derived from mRNA, it is possible to type a human carbamyl phosphate synthetase I with regard to the human carbamyl phosphate synthetase I polymorphism, for example, in the context of diagnosing and treating hepatic veno-occlusive disease (HVOD) associated with bone marrow transplants.

US Patent:

20170119715, May 4, 2017

Filed:

Nov 4, 2016

Appl. No.:

15/343998

Inventors:

- Nashville TN, US
Brian W. Christman - Nashville TN, US
Frederick E. Barr - Nashville TN, US

International Classification:

A61K 31/198

Abstract:

Isolated polynucleotide molecules and peptides encoded by these molecules are used in the analysis of human carbamyl phosphate synthetase I phenotypes, as well as in diagnostic and therapeutic applications, relating to a human carbamyl phosphate synthetase I polymorphism. By analyzing genomic DNA or amplified genomic DNA, or amplified cDNA derived from mRNA, it is possible to type a human carbamyl phosphate synthetase I with regard to the human carbamyl phosphate synthetase I polymorphism, for example, in the context of diagnosing and treating hepatic veno-occlusive disease (HVOD) associated with bone marrow transplants.

US Patent:

20160317484, Nov 3, 2016

Filed:

Jun 10, 2016

Appl. No.:

15/178834

Inventors:

- Nashville TN, US
Brian W. CHRISTMAN - Nashville TN, US
Frederick E. BARR - Nashville TN, US

International Classification:

A61K 31/198
C12Q 1/68
C12N 9/00

Abstract:

Isolated polynucleotide molecules and peptides encoded by these molecules are used in the analysis of human carbamyl phosphate synthetase I phenotypes, as well as in diagnostic and therapeutic applications, relating to a human carbamyl phosphate synthetase I polymorphism. By analyzing genomic DNA or amplified genomic DNA, or amplified cDNA derived from mRNA, it is possible to type a human carbamyl phosphate synthetase I with regard to the human carbamyl phosphate synthetase I polymorphism, for example, in the context of diagnosing and treating hepatic veno-occlusive disease (HVOD) associated with bone marrow transplants.