Brian R Day

US Patent:

6479477, Nov 12, 2002

Filed:

Apr 23, 1999

Appl. No.:

09/296615

Inventors:

James D. Crapo - Englewood CO
Brian J. Day - Englewood CO
Polivina Jolicia F. Gauuan - Albany NY
Michael P. Trova - Schenectady NY

Assignee:

Duke University - Durham NC
Aeolus Pharmaceuticals, Inc. - Research Triangle Park NC

International Classification:

A61K 5104

US Classification:

514183, 514410, 540145

Abstract:

The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods. Compounds of the invention include those of Formula I.

US Patent:

6544975, Apr 8, 2003

Filed:

Jan 25, 2000

Appl. No.:

09/490537

Inventors:

James D. Crapo - Englewood CO
Brian J. Day - Englewood CO
Michael P. Trova - Schenectady NY
Polivina Jolicia F. Gauuan - Albany NY
Douglas B. Kitchen - Schenectady NY
Irwin Fridovich - Durham NC
Ines Batinic-Haberle - Durham NC

Assignee:

National Jewish Medical and Research Center - Denver CO
Aeolus Pharmaceuticals INC - Research Triangle Park NC
Duke University - Durham NC

International Classification:

A61K 31409

US Classification:

514185, 514365, 514383, 514397, 514406, 514410, 540145

Abstract:

The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.

US Patent:

7189707, Mar 13, 2007

Filed:

Jan 23, 2003

Appl. No.:

10/349171

Inventors:

James D. Crapo - Englewood CO, US
Brian J. Day - Englewood CO, US
Michael P. Trova - Schenectady NY, US
Polivina Jolicia F. Gauuan - Albany NY, US
Douglas B. Kitchen - Schenectady NY, US
Irwin Fridovich - Durham NC, US
Ines Batinic-Haberle - Durham NC, US

Assignee:

National Jewish Medical Research Center - Denver CO
Duke University - Durham NC
Aeolus Sciences, Inc. - Laguna Niguel CA

International Classification:

A61K 31/409

US Classification:

514185, 514365, 514383, 514397, 514406, 514410

Abstract:

The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.

US Patent:

7498047, Mar 3, 2009

Filed:

Aug 24, 2005

Appl. No.:

11/211369

Inventors:

Brian J. Day - Englewood CO, US
Richard T. Sawyer - Rockville MD, US
Lee S. Newman - Denver CO, US

Assignee:

National Jewish Medical and Research Center - Denver CO

International Classification:

A61K 35/42

US Classification:

424557, 435 77

Abstract:

Methods for therapy of cystic fibrosis and other conditions are provided. The methods comprise one or more agents capable of increasing thiol-containing compound transport via a transporter system (i. e. ABC transporters such as MDR-1 or MRP-2) in cells. Other embodiments include the use of agents to modulate transport of thiol-containing compounds within the cell. Therapeutic methods involve the administration of such agents to a patient afflicted with cystic fibrosis and/or another condition responsive to stimulation of thiol-containing compound transport.

US Patent:

7790762, Sep 7, 2010

Filed:

Nov 15, 2005

Appl. No.:

11/280959

Inventors:

Brian J. Day - Englewood CO, US
Remy Kachadourian - Denver CO, US

Assignee:

National Jewish Health - Denver CO

International Classification:

A61K 31/4164
C07D 233/60

US Classification:

514396, 5483415

Abstract:

Methods for therapy of cystic fibrosis and other conditions such as cancer are provided. The methods comprise one or more agents capable of increasing thiol-containing compound transport via a transporter system (i. e. ABC transporters such as MDR-1 or MRP-2) in cells. Other embodiments include the use of agents to modulate transport of thiol-containing compounds within the cell. Therapeutic methods involve the administration of such agents to a patient afflicted with cystic fibrosis, cancer and/or another condition responsive to stimulation of thiol-containing compound transport.

US Patent:

7820644, Oct 26, 2010

Filed:

Jun 16, 2006

Appl. No.:

11/424662

Inventors:

James D. Crapo - Englewood CO, US
Brian J. Day - Englewood CO, US
Michael P. Trova - Schenectady NY, US
Polivina Jolicia F. Gauuan - Albany NY, US
Douglas B. Kitchen - Schenectady NY, US
Irwin Fridovich - Durham NC, US
Ines Batinic-Haberle - Durham NC, US

Assignee:

Aelous Pharmaceuticals, Inc. - Mission Viejo CA

International Classification:

A01N 55/02
A01N 43/36
A61K 31/40
C07B 47/00
C07B 487/22

US Classification:

514185, 514410, 540145

Abstract:

The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.

US Patent:

8217026, Jul 10, 2012

Filed:

Sep 17, 2010

Appl. No.:

12/885198

Inventors:

James D. Crapo - Englewood CO, US
Brian J. Day - Englewood CO, US
Michael P. Trova - Schenectady NY, US
Douglas B. Kitchen - Schenectady NY, US
Irwin Fridovich - Durham NC, US
Ines Batinic-Haberle - Durham NC, US

Assignee:

Aeolus Sciences, Inc. - Mission Viejo CA
National Jewish Health - Durham NC
Duke University - Denver CO

International Classification:

A01N 55/02
A01N 43/36
A61K 31/40
C07B 47/00
C07B 487/22

US Classification:

514185, 514410, 540145

Abstract:

The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.

US Patent:

8470808, Jun 25, 2013

Filed:

Nov 8, 2010

Appl. No.:

12/941933

Inventors:

Jon D. Piganelli - Pittsburgh PA, US
Kathryn Haskins - Denver CO, US
Sonia C. Flores - Denver CO, US
James D. Crapo - Denver CO, US
Brian J. Day - Denver CO, US
Ronald G. Gill - Denver CO, US
Richard Gammans - Mission Viejo CA, US
Manisha Patel - Denver CO, US

International Classification:

A61K 31/555
A61K 31/40

US Classification:

514185, 514410, 514866

Abstract:

The present invention relates, in one embodiment, to a method of preventing or treating diabetes using low molecular weight antioxidants. In a further embodiment, the invention relates to a method of protecting and/or enhancing viability of cells/tissues/organs during isolation (harvesting), preservation, expansion and/or transplantation. In yet another embodiment, the present invention relates to a method of inducing immune tolerance. The invention also relates to compounds and compositions suitable for use in such methods.