Brian Jack Day

US Patent:

6479477, Nov 12, 2002

Filed:

Apr 23, 1999

Appl. No.:

09/296615

Inventors:

James D. Crapo - Englewood CO
Brian J. Day - Englewood CO
Polivina Jolicia F. Gauuan - Albany NY
Michael P. Trova - Schenectady NY

Assignee:

Duke University - Durham NC
Aeolus Pharmaceuticals, Inc. - Research Triangle Park NC

International Classification:

A61K 5104

US Classification:

514183, 514410, 540145

Abstract:

The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods. Compounds of the invention include those of Formula I.

US Patent:

6544975, Apr 8, 2003

Filed:

Jan 25, 2000

Appl. No.:

09/490537

Inventors:

James D. Crapo - Englewood CO
Brian J. Day - Englewood CO
Michael P. Trova - Schenectady NY
Polivina Jolicia F. Gauuan - Albany NY
Douglas B. Kitchen - Schenectady NY
Irwin Fridovich - Durham NC
Ines Batinic-Haberle - Durham NC

Assignee:

National Jewish Medical and Research Center - Denver CO
Aeolus Pharmaceuticals INC - Research Triangle Park NC
Duke University - Durham NC

International Classification:

A61K 31409

US Classification:

514185, 514365, 514383, 514397, 514406, 514410, 540145

Abstract:

The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.

US Patent:

6583132, Jun 24, 2003

Filed:

Nov 30, 1998

Appl. No.:

09/201722

Inventors:

James D. Crapo - Durham NC
Irwin Fridovich - Durham NC
Tim Oury - Durham NC
Brian J. Day - Durham NC
Rodney J. Folz - Durham NC
Bruce A. Freeman - Birmingham AL
Michael P. Trova - Schenectady NY
Ines Batinic-Haberle - Durham NC

Assignee:

Duke University - Durham NC
University of Alabama at Birmingham Research Foundation - Birmingham AL
Aeolus Pharmaceuticals, Inc. - Research Triangle Park NC

International Classification:

A61K 31555

US Classification:

514185

Abstract:

The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating intra- and extracellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.

US Patent:

6900026, May 31, 2005

Filed:

Nov 9, 2001

Appl. No.:

10/039869

Inventors:

Douglas C. Wallace - Atlanta GA, US
Simon Melov - Atlanta GA, US
James D. Crapo - Cherry Hills Village CO, US
Brian J. Day - Englewood CO, US

Assignee:

Duke University - Durham NC
Emory University - Atlanta GA

International Classification:

C12Q001/34

US Classification:

435 18, 424 92

Abstract:

The present application describes methods for the testing of compounds of potential usefulness as therapeutic antioxidants and/or as therapeutic free radical scavengers. The animal model for testing such compounds is the Sod2CJE homozygous Manganese Superoxide Dismutase-deficient mouse. When pups of these mice are treated with certain antioxidants, they survive past about 7 days of age, and later develop characteristic histological changes and characteristic neurobehavioral disorders. Those treated mice can be further treated with test compounds which may or may not cross the blood brain barrier, and the life span and physical and neurobehavioral characteristics of those mice provide information about the potential utility of the test compound as a therapeutic antioxidant. Phenotypes of the treated mice allow conclusions regarding targeted areas of the brain and thus, applications to particular disorders such as Parkinsonism.

US Patent:

6916799, Jul 12, 2005

Filed:

Jun 14, 2001

Appl. No.:

09/880125

Inventors:

Irwin Fridovich - Durham NC, US
Ines Batinic-Haberle - Durham NC, US
James D. Crapo - Englewood CO, US
Brian J. Day - Englewood CO, US

Assignee:

Duke University - Durham NC
National Jewish Medical and Research Center - Denver CO

International Classification:

C07D487/22
A61K031/409
A61K031/555
A61P011/06

US Classification:

514183, 514184, 514185, 540145

Abstract:

The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.

US Patent:

7189707, Mar 13, 2007

Filed:

Jan 23, 2003

Appl. No.:

10/349171

Inventors:

James D. Crapo - Englewood CO, US
Brian J. Day - Englewood CO, US
Michael P. Trova - Schenectady NY, US
Polivina Jolicia F. Gauuan - Albany NY, US
Douglas B. Kitchen - Schenectady NY, US
Irwin Fridovich - Durham NC, US
Ines Batinic-Haberle - Durham NC, US

Assignee:

National Jewish Medical Research Center - Denver CO
Duke University - Durham NC
Aeolus Sciences, Inc. - Laguna Niguel CA

International Classification:

A61K 31/409

US Classification:

514185, 514365, 514383, 514397, 514406, 514410

Abstract:

The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.

US Patent:

7299384, Nov 20, 2007

Filed:

Aug 17, 2004

Appl. No.:

10/920597

Inventors:

Gustavo Rodriguez-Rivera - West Lafayette IN, US
Michael P. Spertus - Chicago IL, US
Charles Fiterman - Deerfield IL, US
Jim Polubinski - Palos Hills IL, US
Brian Day - Hillside IL, US
Daryl Hoyt - Aurora IL, US
Christopher D. Metcalf - Wellesley MA, US

Assignee:

Symantec Operating Corporation - Cupertino CA

International Classification:

G06F 11/28
G06F 12/14

US Classification:

714 52, 711152, 711173, 717124, 717131

Abstract:

A method and mechanism for managing dynamically allocated memory. Portions of memory which are available for allocation have additional information stored in association with each portion which indicates whether the portion has been previously identified as being prematurely freed. In addition, a checksum is stored with each portion of memory. In response to a request for deallocation of a portion of memory, the portion of memory is not deallocated if it is identified as having been prematurely freed. Otherwise, the a checksum is calculated for the portion and it is freed. In response to an allocation request, a candidate portion of memory is identified for allocation and a checksum is calculated for the candidate portion. If the calculated checksum does not match a checksum previously stored for the candidate portion, the portion is identified as having been prematurely freed and is not returned for allocation.

US Patent:

7470677, Dec 30, 2008

Filed:

Jun 9, 2003

Appl. No.:

10/457071

Inventors:

James D. Crapo - Durham NC, US
Irwin Fridovich - Durham NC, US
Tim Oury - Durham NC, US
Brian J. Day - Durham NC, US
Rodney J. Folz - Durham NC, US
Bruce A. Freeman - Birmingham AL, US
Michael P. Trova - Schenectady NY, US
Ines Batinic-Haberle - Durham NC, US

Assignee:

Aeolus Pharmaceuticals, Inc. - Laguna Niguel CA

International Classification:

A61K 31/555
A61K 33/34
A61K 33/32
A61K 31/28
C07D 487/22
A01N 55/02
A01N 59/20
A01N 59/16

US Classification:

514185, 424630, 424639, 424646, 514492, 540145, 540201

Abstract:

The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating intra- and extracellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.