Brian E Egan

US Patent:

20040058356, Mar 25, 2004

Filed:

Apr 30, 2003

Appl. No.:

10/426734

Inventors:

Mary Warren - Solana Beach CA, US
Christopher Adams - San Diego CA, US
Paul Labhart - San Diego CA, US
Brian Egan - San Diego CA, US
Marc Ballivet - Geneva, CH

International Classification:

C12Q001/68

US Classification:

435/006000

Abstract:

The present invention provides methods for profiling, in a global manner, the activity of gene regulatory elements in cells, including eukaryotic and prokaryotic cells. The methods involve analysis of regulatory element complexes formed under cell-free conditions or within cells (sometimes called “in vivo”). In accordance with the invention, cells can be in any state of metabolism, resting, growing, normal, mutant, diseased or differentiating. The gene regulatory element activity profiles generated for the cells in different cell populations are compared to determine differences in gene regulatory activity and overall gene expression between or among different types or states of cells.

US Patent:

20220356465, Nov 10, 2022

Filed:

Mar 25, 2022

Appl. No.:

17/705005

Inventors:

- Carlsbad CA, US
Brian Stanley EGAN - Carlsbad CA, US
Joseph FERNANDEZ - Carlsbad CA, US

International Classification:

C12N 15/10
C12Q 1/6806
C12Q 1/6804
C07H 21/00

Abstract:

Disclosed herein are compositions, methods and kits useful for epigenetic analysis based on the use of transposons that are targeted to specific regions of chromatin based on DNA-DNA interactions, protein-protein interactions, RNA-RNA interactions, and nucleic acid-protein interactions.

US Patent:

20200299678, Sep 24, 2020

Filed:

Jun 4, 2020

Appl. No.:

16/946073

Inventors:

- Carlsbad CA, US
Brian Stanley EGAN - Carlsbad CA, US
Joseph FERNANDEZ - Carlsbad CA, US

Assignee:

Active Motif, Inc. - Carlsbad CA

International Classification:

C12N 15/10
C12Q 1/6806
C12Q 1/6804
C07H 21/00

Abstract:

Disclosed herein are compositions, methods and kits useful for epigenetic analysis based on the use of transposons that are targeted to specific regions of chromatin based on DNA-DNA interactions, protein-protein interactions, RNA-RNA interactions, and nucleic acid-protein interactions.

US Patent:

20180010121, Jan 11, 2018

Filed:

May 22, 2014

Appl. No.:

14/892911

Inventors:

- Carlsbad CA, US
Brian Stanley Egan - Carlsbad CA, US
Joseph Fernandez - Carlsbad CA, US

Assignee:

Active Motif, Inc. - Carlsbad CA

International Classification:

C12N 15/10
C07H 21/00
C12Q 1/68

Abstract:

Disclosed herein are compositions, methods and kits useful for epigenetic analysis based on the use of transposons that are targeted to specific regions of chromatin based on DNA-DNA interactions, protein-protein interactions, RNA-RNA interactions, and nucleic acid-protein interactions.