Brian M Feldman

US Patent:

7144700, Dec 5, 2006

Filed:

Jul 21, 2000

Appl. No.:

09/620780

Inventors:

Glenn McGall - Mountain View CA, US
Daniel E. Falvey - Takoma Park MD, US
Jacqueline A. Fidanza - Mountain View CA, US
Brian M. Feldman - Pittsford NY, US

Assignee:

Affymetrix, Inc. - Santa Clara CA

International Classification:

C12Q 1/68
C12M 1/34
C07H 21/00
G01N 33/543

US Classification:

435 6, 435 4, 4352831, 4352878, 435DIG 40, 435DIG 42, 435DIG 49, 436518, 436524, 436527, 436106, 436145, 536 253, 536 2531, 536 2532, 536 2533, 536 2534

Abstract:

Methods, employing a polycyclic hydrocarbon or a polycyclic heteroaromatic compound as sensitizers, are provided to increase the efficiency of removing, by irradiation, photolabile protecting groups that mask reactive sites on synthesis intermediaries. Preferred groups of photolabile protecting moieties include: ((α-methyl-2-nitropiperonyl)-oxy)carbonyl (MeNPOC), ((Phenacyl)-oxy)carbonyl (PAOC), O-(9-phenylxanthen-9-yl) (PIXYL), and ((2-methylene-9,10-anthraquinone)-oxy)carbonyl (MAQOC). In conjunction with using the sensitizers and protecting groups described above, a method of forming, from component molecules, a plurality of compounds on a support, each compound occupying a separate predefined region of the support is provided. These resulting solid-phase arrays are useful, for example, to assay for the presence of biochemical products in biological samples.

US Patent:

43548431, Oct 19, 1982

Filed:

May 4, 1979

Appl. No.:

6/036183

Inventors:

Brian Feldman - New York NY

International Classification:

G09B 1900

US Classification:

434236

Abstract:

A light display in which the individual lights are positioned in relation to an x and y axis, and in which further any one selected light is operated in tandem, either automatically or manually by an instructor resulting in the illumination thereof, and then by the patient, usually a child, resulting in the turning off of the light. The operational control over the selected light, as just generally noted, is achieved using correspondingly x and y axis-positioned buttons, thus requiring the patient to determine the corresponding position of the position-related light and button involved, with the result that the patient receives spacial orientation instruction.