Brian Merrill Freed

US Patent:

7253165, Aug 7, 2007

Filed:

May 12, 2004

Appl. No.:

10/844245

Inventors:

Gregory M. Shutske - Pittstown NJ, US
James A. Hendrix - Hillsborough NJ, US
John G. Jurcak - Bethlehem PA, US
Brian S. Freed - Phillipsburg NJ, US
Nicholas J. Hrib - Hillsborough NJ, US
Reda G. Hanna - Allentown PA, US

Assignee:

Aventis Pharmaceuticals Inc. - Bridgewater NJ

International Classification:

C07D 498/02
A61K 31/5377
A61K 31/496

US Classification:

5142325, 51425214, 514256, 514302, 514307, 514379, 514443, 546115, 546139, 548241, 549 49, 544106, 544242, 544359

Abstract:

The compounds are of the class of benzisoxazolyl-, pyridoisoxazolyl- and benzthienyl-phenoxy derivatives, useful as Dantagonists. Said compounds are useful for the treatment of medical conditions mediated by inhibition of Dreceptor. These conditions comprise, for example, Attention Deficit Hyperactivity Disorder, Obsessive-Compulsive Disorder, Psychoses, Substance Abuse, Substance Dependence, Parkinson's Disease, Parkinsonism, Tardive Diskinesia, Gilles de la Tourette Syndrome, Conduct Disorder, and Oppositional Defiant Disorder. A further aspect of the invention is to provide a pharmaceutical composition, intermediates, and a method of making said class of compounds.

US Patent:

7541368, Jun 2, 2009

Filed:

Nov 1, 2005

Appl. No.:

11/264063

Inventors:

David Roger Borcherding - Bangor PA, US
Alexandre Gross - Jersey City NJ, US
Patrick W. Shum - Flemington NJ, US
Nicole Willard - Doylestown PA, US
Brian S. Freed - Phillipsburg NJ, US

Assignee:

Aventis Pharmaceuticals Inc. - Bridgewater NJ

International Classification:

C07D 401/00
C07D 405/00
C07D 409/00
C07D 411/00
C07D 413/00
C07D 417/00
C07D 419/00
A01N 43/42
A01N 43/40
A61K 31/44
A61K 31/445

US Classification:

514304, 514326, 546125, 546208

Abstract:

The present invention provides compounds of Formula (I).

US Patent:

59170573, Jun 29, 1999

Filed:

Feb 27, 1998

Appl. No.:

9/032240

Inventors:

Richard C. Allen - Flemington NJ
Grover C. Helsley - Stockton NJ
R. Richard L. Hamer - Lebanon NJ
Brian S. Freed - Somerset NJ
John I. White - Chapel Hill NC
Lawrence L. Martin - Lebanon NJ

Assignee:

Hoechst Marion Roussel, Inc. - Bridgewater NJ

International Classification:

C07D33374
C07D31300
A61K 3138
A61K 31335

US Classification:

549 48

Abstract:

This invention relates to N-hydroxy-dibenz�b,e!oxepinalkylamines, N-hydroxy-dibenz�b,e!oxepinalkanoic acid amides and related heterocyclic analogues of the formula ##STR1## where X together with the carbon atoms to which it is attached forms a benzene or thiophene ring; W and Z are independently hydrogen, halogen, loweralkyl, or trifluoromethyl; R. sup. 1 is hydrogen, arylloweralkyl, loweralkoxycarbonyl, loweralkylcarbonyl, arylcarbonyl or arylloweralkylcarbonyl; R. sup. 2 is loweralkyl, cycloalkyl, arylloweralkyl, loweralkoxycarbonyl, loweralkylcarbonyl, arylcarbonyl or arylloweralkylcarbonyl; m is 0 or 1 and n is an integer of 0 to 4 or the pharmaceutically acceptable salts thereof. The compounds of this invention are useful as analgesics and topical antiinflammatory agents for the treatment of various dermatoses and agents for the treatment of conditions where accumulation of cyclooxygenase and/or lipoxygenase metabolites is a causative factor.

US Patent:

56840217, Nov 4, 1997

Filed:

Jun 1, 1995

Appl. No.:

8/457259

Inventors:

Gregory M. Shutske - Pittstown NJ
Brian S. Freed - Phillipsburg NJ
John D. Tomer - Perkasie PA
R. Richard L. Hamer - Lebanon NJ

Assignee:

Hoechst Marion Roussel, Inc. - Cincinnati OH

International Classification:

C07D29513
A61K 31445
A61K 31535
A61K 3154

US Classification:

514331

Abstract:

Novel aminoalkyloximes, precursors and processes for the preparation thereof, and methods of treating depression and obsessive compulsive disorders are described.

US Patent:

56961421, Dec 9, 1997

Filed:

Jun 1, 1995

Appl. No.:

8/456969

Inventors:

Gregory M. Shutske - Pittstown NJ
Brian S. Freed - Phillipsburg NJ
John D. Tomer - Perkasie PA
R. Richard L. Hamer - Lebanon NJ

Assignee:

Hoechst Marion Roussel, Inc. - Cincinnati OH

International Classification:

C07D23364
C07D23361
A61K 31415

US Classification:

514399

Abstract:

Novel aminoalkyloximes, precursors and processes for the preparation thereof, and methods of treating depression and obsessive compulsive disorders are described.

US Patent:

56864833, Nov 11, 1997

Filed:

Jun 1, 1995

Appl. No.:

8/457422

Inventors:

Gregory M. Shutske - Pittstown NJ
Brian S. Freed - Phillipsburg NJ
John D. Tomer - Perkasie PA
R. Richard L. Hamer - Lebanon NJ

Assignee:

Hoechst Marion Roussel, Inc. - Cincinnati OH

International Classification:

C07D29513
C07D20708
C07D40304
C07D40312

US Classification:

514428

Abstract:

Novel aminoalkyloximes, precursors and processes for the preparation thereof, and methods of treating depression and obsessive compulsive disorders are described.

US Patent:

56483678, Jul 15, 1997

Filed:

Jun 1, 1995

Appl. No.:

8/457081

Inventors:

Gregory M. Shutske - Pittstown NJ
Brian S. Freed - Phillipsburg NJ
John D. Tomer - Perkasie PA
R. Richard L. Hamer - Lebanon NJ

Assignee:

Hoechst Marion Roussel, Inc. - Cincinnati OH

International Classification:

C07D21132
C07D 4010
C07D40106
A61K 31445

US Classification:

514330

Abstract:

Novel aminoalkyloximes, precursors and processes for the preparation thereof, and methods of treating depression and obsessive compulsive disorders are described.

US Patent:

56864469, Nov 11, 1997

Filed:

Jun 1, 1995

Appl. No.:

8/457681

Inventors:

Gregory M. Shutske - Pittstown NJ
Brian S. Freed - Phillipsburg NJ
John D. Tomer - Perkasie PA
R. Richard L. Hamer - Lebanon NJ

Assignee:

Hoechst Marion Roussel, Inc. - Cincinnati OH

International Classification:

C07D40312
C07D40304
C07D29513
C07D20708

US Classification:

514212

Abstract:

Novel aminoalkyloximes, precursors and processes for the preparation thereof, and methods of treating depression and obsessive compulsive disorders are described.