Brian K Green

US Patent:

20210205519, Jul 8, 2021

Filed:

Mar 25, 2021

Appl. No.:

17/212866

Inventors:

- Lawrence MA, US
Dennis M. TREU - Castle Rock CO, US
Goetz FRIEDERICHS - Beverly MA, US
Brian C. GREEN - Westford MA, US
Christopher S. MCDOWELL - Murray UT, US
James M. BRUGGER - Newburyport MA, US

Assignee:

NxStage Medical, Inc. - Lawrence MA

International Classification:

A61M 1/16
A61M 1/28
A61M 1/14
A61M 1/34
C02F 1/44

Abstract:

A fluid treatment plant has a filter module including at least a first filter and a second filter connected in series and connectable to a supply of fluid. A pump is fluidly connected to the filter module and a controller with a fluid quality sensor is connected to detect a quality of the fluid between the first filter and the second filter. A filter module detector is connected to the controller configured to uniquely detect a filter module connected to the pump, and the controller is controls the pump responsively to a signal from the fluid quality sensor and the module detector. The controller is configured to continue pumping based on output of the quality sensor and/or based on output from the filter module detector.

US Patent:

20200181179, Jun 11, 2020

Filed:

Jul 17, 2018

Appl. No.:

16/631963

Inventors:

- Lutherville MD, US
Matthew Richard Oberholzer - Wilmington DE, US
Brian Michael Green - Lutherville MD, US
Samir Kulkarni - East Lyme CT, US
Jennifer Nelson - Kokomo IN, US
Patricia Andres - West Lafayette IN, US

Assignee:

AGRIMETIS, LLC - Lutherville MD

International Classification:

C07F 9/535

Abstract:

Compositions and methods for isolating L-glufosinate from a composition comprising L-glufosinate and glutamate are provided. The method comprises converting the glutamate to pyroglutamate followed by the isolation of L-glufosinate from the pyroglutamate and other components of the composition to obtain substantially purified L-glufosinate. The composition comprising L-glufosinate and glutamate is subjected to an elevated temperature for a sufficient time to allow for the conversion of glutamate to pyroglutamate, followed by the isolation of L-glufosinate from the pyroglutamate and other components of the composition to obtain substantially purified L-glufosinate. The glutamate alternatively may be converted to pyroglutamate by enzymatic conversion. The purified L-glufosinate is present in a final composition at a concentration of 90% or greater of the sum of L-glufosinate, glutamate, and pyroglutamate. In some embodiments, a portion of the glutamate in the starting composition may be separated from the L-glufosinate using a crystallization step. Solid forms of L-glufosinate materials, including crystalline L-glufosinate ammonium, are also described.

US Patent:

20190275226, Sep 12, 2019

Filed:

May 28, 2019

Appl. No.:

16/423214

Inventors:

- Lawrence MA, US
Dennis M. TREU - Castle Rock CO, US
Goetz FRIEDERICHS - Boston MA, US
Brian C. GREEN - Westford MA, US
Christopher S. MCDOWELL - Murray UT, US
James M. BRUGGER - Newburyport MA, US

Assignee:

NxStage Medical, Inc. - Lawrence MA

International Classification:

A61M 1/16
A61M 1/14
A61M 1/28
A61M 1/34
C02F 1/44

Abstract:

A fluid preparation system has a sealed sterilized fluid circuit with a sealed sterilized container with a conductivity sensor in communication with an interior of said container. Further, at least one sealed connector is adapted for adding fluid to said container, and at least one sealed connector is adapted for removing fluid from said container. The conductivity sensor is contained in a test line in communication with said interior and is adapted to be connected to a source of suction thereby to draw a sample of contents of said container. Furthermore, the test line may have a check valve to prevent ingress of contaminants into said container, and the sealed connector is adapted for adding fluid to said container and may have an inline sterile filter. Furthermore, the system may have a controller that controls pumping actuators.

US Patent:

20170266360, Sep 21, 2017

Filed:

Jun 6, 2017

Appl. No.:

15/615655

Inventors:

- Lawrence MA, US
Dennis M. TREU - Castle Rock CO, US
Goetz FRIEDERICHS - Boston MA, US
Brian C. GREEN - Westford MA, US
Christopher S. MCDOWELL - Holladay UT, US
James M. BRUGGER - Newburyport MA, US

Assignee:

NXSTAGE MEDICAL, INC. - Lawrence MA

International Classification:

A61M 1/16
A61M 1/28

Abstract:

A fluid preparation system has a sealed sterilized fluid circuit with a sealed sterilized container with a conductivity sensor in communication with an interior of said container. Further, at least one sealed connector is adapted for adding fluid to said container, and at least one sealed connector is adapted for removing fluid from said container. The conductivity sensor is contained in a test line in communication with said interior and is adapted to be connected to a source of suction thereby to draw a sample of contents of said container. Furthermore, the test line may have a check valve to prevent ingress of contaminants into said container, and the sealed connector is adapted for adding fluid to said container and may have an inline sterile filter. Furthermore, the system may have a controller that controls pumping actuators.