Brian David Holmes

US Patent:

6613009, Sep 2, 2003

Filed:

Aug 19, 1997

Appl. No.:

08/914405

Inventors:

Marlene Adele Bainbridge - Littleton CO
Brian M. Holmes - Evergreen CO

Assignee:

Gambro, Inc. - Lakewood CA

International Classification:

A61M 3700

US Classification:

604 601, 604 401, 604 604, 604 602, 210782, 494 35, 494 45

Abstract:

An extracorporeal blood processing system is disclosed which includes a variety of novel components and which may be operated in accordance with a variety of novel methodologies. For instance, the system includes a graphical operator interface which directs the operator through various aspects of the apheresis procedure. Moreover, the system also includes a variety of features relating to loading a blood processing vessel into a blood processing channel and removing the same after completion of the procedure. Furthermore, the system also includes a variety of features relating to utilizing a blood priming of at least portions of the apheresis system in preparation for the procedure. In addition, the system includes a variety of features enhancing the performance of the apheresis system, including the interrelationship between the blood processing vessel and the blood processing vessel and the utilization of high packing factors for the procedure.

US Patent:

6902539, Jun 7, 2005

Filed:

Apr 3, 2003

Appl. No.:

10/407591

Inventors:

Marlene Adele Bainbridge - Golden CO, US
Brian M. Holmes - Lakewood CO, US

Assignee:

GamBro Inc - Lakewood CO

International Classification:

A61M037/00
B04B003/00
B04B009/10
C02F001/00
B01D045/12

US Classification:

604 601, 604 602, 604 611, 210782, 210740, 494 7, 494 37

Abstract:

An extracorporeal blood processing system is disclosed which includes a variety of novel components and which may be operated in accordance with a variety of novel methodologies. For instance, the system includes a graphical operator interface which directs the operator through various aspects of the apheresis procedure. Moreover, the system also includes a variety of features relating to loading a blood processing vessel into a blood processing channel and removing the same after completion of the procedure. Furthermore, the system also includes a variety of features relating to utilizing a blood priming of at least portions of the apheresis system in preparation for the procedure. In addition, the system includes a variety of features enhancing the performance of the apheresis system, including the interrelationship between the blood processing vessel and the blood processing vessel and the utilization of high packing factors for the procedure.

US Patent:

7166217, Jan 23, 2007

Filed:

Aug 25, 2003

Appl. No.:

10/648559

Inventors:

Brian M. Holmes - Lakewood CO, US
J-P Hagström - Hägersten, SE
Per-Olov Lundberg - Karlskoga, SE
Geert Van Waeg - Brussels, BE
Peter Nordgren - Stockholm, SE

Assignee:

Gambro Inc - Lakewood CO

International Classification:

B04B 1/00
A61M 1/36

US Classification:

2102571, 210252, 2103601, 210782, 604 401, 604 601, 604 615, 494 18, 494 45, 422 72, 422101, 422102

Abstract:

A system for separating a composite fluid into component parts thereof, including: a centrifuge having a rotor with a separation space and at least two valve members disposed thereon and a container set having a separation container adapted to be disposed in the separation space of the rotor and first and second collection containers connected to the separation container by a first and a second tubes. The tubes are adapted to be disposed in operative relationship with the valve members so that flow through the tubes may be controlled thereby. Three components of the composite fluid may be separated therefrom by the present system and two components may be moved to the collection containers. The container set may further include a third collection container connected to the separation container by a tube, and a third component may thus be moved to this third container.

US Patent:

7279107, Oct 9, 2007

Filed:

Apr 16, 2003

Appl. No.:

10/414475

Inventors:

Niclas Högberg - Karlskoga, SE
Emanuel Hällgren - Karlskoga, SE
Peter Pihlstedt - Stockholm, SE
Brian M. Holmes - Lakewood CO, US
Lars Persson - Askersund, SE
Lars Strandberg - Gävle, SE
Geert Van Waeg - Brussels, BE
Frank Corbin, III - Littleton CO, US

Assignee:

Gambro, Inc. - Lakewood CO

International Classification:

B01D 21/26
B04B 11/00

US Classification:

210745, 210741, 210792, 210806, 210 97, 210103, 210143, 2102571, 210258, 210295, 210304, 2103601, 2103801, 2104161, 494 2, 494 36, 494 37, 494 45, 604406, 604408, 604410

Abstract:

A system and method are used in connection with processing of blood components. The processing of blood components may involve centrifugal separation and/or filtering of the blood components. In some examples, at least some blood components are centrifugally separated in a chamber and then filtered via a filter rotating along with a centrifuge rotor, wherein the filter is located closer than the chamber to an axis of rotation of the rotor. The filter may include a porous filtration medium configured to filter leukocytes, platelets, and/or red blood cells. Some examples include a pressure sensor sensing pressure of pumped blood components. The sensed pressure may be used in connection with controlling the pumping of the blood products and/or in connection with determining the location of an interface associated with the blood products. Other uses of the sensed pressure are also possible.

US Patent:

7347932, Mar 25, 2008

Filed:

Feb 20, 2004

Appl. No.:

10/783831

Inventors:

Brian M. Holmes - Lakewood CO, US
Peter Pihlstedt - Stockholm, SE
Geert Van Waeg - Brussels, BE

Assignee:

Gambro BCT, Inc. - Lakewood CO

International Classification:

B04B 1/00
B04B 13/00
A61M 1/36

US Classification:

210104, 210739, 210782, 210143, 2103601, 2103801, 422 72, 494 18, 494 45, 604 601, 604 615

Abstract:

A method for separating a volume of a composite liquid into at least a first component and a second component is performed in a centrifuge cooperating with a separation bag containing the volume of composite liquid. The separation bag is connected to at least a first component bag and a second component bag. The separation bag is spun so as to centrifuge the volume of composite liquid and cause the sedimentation of the at least first and second components. When the at least first and second components have sedimented, the first component is transferred at at least one first transfer flow rate into the first component bag. When the first component has been transferred into the first component bag, the second component is transferred into the intermediate component bag at at least one second transfer flow rate that is different from the at least one first transfer flow rate.

US Patent:

7396451, Jul 8, 2008

Filed:

Dec 15, 2006

Appl. No.:

11/611682

Inventors:

Brian M. Holmes - Lakewood CO, US
Johan-Petter Hagström - Hägersten, SE
Per-Olov Lundberg - Karlskoga, SE
Geert Van Waeg - Brussels, BE
Peter Nordgren - Stockholm, SE

Assignee:

Gambo BCI, Inc. - Lakewood CO

International Classification:

B01D 21/26
B04B 11/00
B04B 13/00

US Classification:

210103, 210739, 210741, 210745, 210782, 210787, 210806, 210 97, 210143, 2102571, 210258, 210259, 210295, 210304, 2103601, 2103801, 2104161, 494 2, 494 36, 494 37, 494 45, 604406, 604408, 604410

Abstract:

A system for separating a composite fluid into component parts thereof, including: a centrifuge having a rotor with a separation space and at least two valve members disposed thereon and a container set having a separation container adapted to be disposed in the separation space of the rotor and first and second collection containers connected to the separation container by a first and a second tubes. The tubes are adapted to be disposed in operative relationship with the valve members so that flow through the tubes may be controlled thereby. Three components of the composite fluid may be separated therefrom by the present system and two components may be moved to the collection containers. The container set may further include a third collection container connected to the separation container by a tube, and a third component may thus be moved to this third container.

US Patent:

7413665, Aug 19, 2008

Filed:

Dec 15, 2006

Appl. No.:

11/611567

Inventors:

Brian M. Holmes - Lakewood CO, US
Johan-Petter Hagström - Hägersten, SE
Per-Olov Lundberg - Karlskoga, SE
Geert Van Waeg - Brussels, BE
Peter Nordgren - Stockholm, SE

Assignee:

Gambro BCT, Inc. - Lakewood CO

International Classification:

B01D 21/26
B04B 11/00
B04B 13/00

US Classification:

210741, 210739, 210745, 210782, 210787, 210806, 210 97, 210103, 210143, 2102571, 210258, 210259, 210295, 210304, 2103601, 2103801, 2104161, 494 2, 494 36, 494 37, 494 45, 604406, 604408, 604410

Abstract:

A system for separating a composite fluid into component parts thereof, including: a centrifuge having a rotor with a separation space and at least two valve members disposed thereon and a container set having a separation container adapted to be disposed in the separation space of the rotor and first and second collection containers connected to the separation container by a first and a second tubes. The tubes are adapted to be disposed in operative relationship with the valve members so that flow through the tubes may be controlled thereby. Three components of the composite fluid may be separated therefrom by the present system and two components may be moved to the collection containers. The container set may further include a third collection container connected to the separation container by a tube, and a third component may thus be moved to this third container.

US Patent:

7497944, Mar 3, 2009

Filed:

Mar 27, 2007

Appl. No.:

11/727550

Inventors:

Niclas Högberg - Karlskoga, SE
Emanuel Hällgren - Karlskoga, SE
Peter Pihlstedt - Stockholm, SE
Brian M. Holmes - Lakewood CO, US
Lars Persson - Askersund, SE
Lars Strandberg - Gävle, SE
Geert Van Waeg - Brussels, BE
Frank Corbin, III - Littleton CO, US

Assignee:

CaridianBCT, Inc. - Lakewood CO

International Classification:

B01D 21/30
B04B 5/02
B04B 5/04

US Classification:

210103, 210741, 210745, 210143, 210258, 210295, 210304, 2103601, 2103801, 2104161, 494 2, 494 36, 494 37, 494 45, 604406, 604408, 604410

Abstract:

A system and method are used in connection with processing of blood components. The processing of blood components may involve centrifugal separation and/or filtering of the blood components. In some examples, at least some blood components are centrifugally separated in a chamber and then filtered via a filter rotating along with a centrifuge rotor, wherein the filter is located closer than the chamber to an axis of rotation of the rotor. The filter may include a porous filtration medium configured to filter leukocytes, platelets, and/or red blood cells. Some examples include a pressure sensor sensing pressure of pumped blood components. The sensed pressure may be used in connection with controlling the pumping of the blood products and/or in connection with determining the location of an interface associated with the blood products. Other uses of the sensed pressure are also possible.