Brian M Levy

US Patent:

20060257391, Nov 16, 2006

Filed:

May 11, 2005

Appl. No.:

11/126625

Inventors:

Stephen Bartels - New York NY, US
Gregory McIntire - Rochester NY, US
Timothy Comstock - Rochester NY, US
Brian Levy - Rochester NY, US

International Classification:

A61K 38/48

US Classification:

424094640

Abstract:

A non-surgical method for preventing or reducing the rate of the progression of non-proliferative diabetic retinopathy to the proliferative form of diabetic retinopathy comprising intravitreally administering to a patient suffering from non-proliferative diabetic retinopathy an effective amount of serine proteinase enzyme sufficient to create, without surgery, a posterior vitreal detachment to prevent or reduce the progression of proliferative diabetic retinopathy in said patient. Also disclosed is a non-surgical method of treating ocular conditions such as retinal ischemia, retinal inflammation, retinal edema tractional retinal detachment, tractional retinopathy, vitreous hemorrhage and tractional maculopathy by intravitreally administering to a patient suffering from one or more of these conditions with an effective amount of a serine proteinase enzyme to reduce or treat that particular ocular condition. Plasmin, microplasmin and miniplasmin are preferred serine proteinase enzymes and plasmin is the most preferred.

US Patent:

20110020453, Jan 27, 2011

Filed:

Feb 8, 2010

Appl. No.:

12/702064

Inventors:

Steven Blum - New York NY, US
Barrett Katz - New York NY, US
Christopher Wilfong - New York NY, US
Brian Levy - New York NY, US

International Classification:

A61K 9/14
A61K 31/352
A61P 27/06

US Classification:

424489, 514456, 977773, 977788, 977915

Abstract:

Disclosed herein are pharmaceutical formulations comprising particles of formula 1:wherein R, R, R, R, R, R, n and * are each defined in specification. Also disclosed are methods of decreasing intraocular pressure comprising topically applying a benzopyranyl guanidine derivative of formula 1 to an eye.

US Patent:

20110070310, Mar 24, 2011

Filed:

Dec 14, 2010

Appl. No.:

12/967618

Inventors:

Steven Blum - New York NY, US
Barrett Katz - New York NY, US
Christopher Wilfong - New York NY, US
Brian Levy - New York NY, US

Assignee:

MESH THERAPEUTICS, LLC - New York NY

International Classification:

A61K 31/352
A61K 9/14
A61P 27/06

US Classification:

424489, 514456

Abstract:

A topical ophthalmic pharmaceutical formulation may include particles of the compound (2S,3S,4R)—N″-cyano-N-(6-amino-3,4-dihydro-3-hydroxy-2-methyl-2-dimethoxymethyl-2H-benzopyran-4-yl)-N′-benzylguanidine suspended in a solution comprising monobasic sodium phosphate monohydrate, disodium phosphate heptahydrate, edetate disodium, benzalkonium chloride, sodium chloride, polysorbate 80, and water. A method of treating glaucoma may include topically applying to the eye of a patient in need thereof a therapeutically effective amount of this formulation.