A method of increasing hematopoietic stem cell production is disclosed. The method includes administering a TPO mimetic compound to a subject. Pharmaceutical compositions including a TPO mimetic compound and a pharmaceutically acceptable carrier are also disclosed.
Methods Of Increasing Platelet And Hematopoietic Stem Cell Production
Brian R. MacDonald - Bryn Mawr PA, US Kenneth Kaushansky - Del Mar CA, US
Assignee:
Janssen Pharmaceutica, NV - Beerse
International Classification:
A61K 38/02
US Classification:
514 78, 424 851, 4241981, 514 79, 530300
Abstract:
A method of increasing hematopoietic stem cell production is disclosed. The method includes administering a TPO mimetic compound to a subject. Pharmaceutical compositions including a TPO mimetic compound and a pharmaceutically acceptable carrier are also disclosed.
Method Of Treating Immune Cell Mediated Systemic Diseases
Peter Bugelski - Drexel Hill PA, US Charles Davis - Devon PA, US Brian MacDonald - Valley Forge PA, US
Assignee:
SmithKline Beecham Corporation
International Classification:
A61K038/16 A61K039/395
US Classification:
514/008000, 424/131100
Abstract:
An improved method of treating immune cell mediated systemic diseases, particularly T and B cell mediated diseases, is provided by increasing the systemic exposure, or bioavailibility, of a therapeutic protein. Such therapeutic protein is selected from the group consisting of a monoclonal antibody, a soluble receptor and a soluble ligand which binds to an antigen expressed on the surface of an immunce cell.
Disclosed is a method of treatment of psoriasis which comprises administering to a patient in need thereof by the oral route a pharmaceutical composition comprising rosiglitazone, or a pharmaceutically acceptable salt or solvate thereof, together with a pharmaceutically acceptable carrier, wherein the method comprises administering 2 to 8 mg rosiglitazone per day.
Paul Morley - Ottawa, CA Martin Stogniew - Blue Bell PA, US Brian MacDonald - Newtown Square PA, US
International Classification:
A61K 38/29 A61P 19/10
US Classification:
514012000
Abstract:
The present invention is directed to novel methods of treating a subject with a bone deficit disorder. The methods generally include administering to a subject in need thereof a pharmaceutically acceptable formulation comprising a parathyroid hormone (PTH) peptide analogue in a daily dose sufficient to result in an effective pharmacokinetic profile and maintained adenylate cyclase activity, while simultaneously reducing undesirable side effects.
Paul Morley - Ottawa, CA Martin Stogniew - Blue Bell PA, US Brian MacDonald - Newtown Square PA, US Gene Scott Merutka - Phoenixville PA, US Nagesh Palepu - Southampton PA, US
International Classification:
A61K 38/16 A61P 19/00 A61P 19/10
US Classification:
514 11, 514 12
Abstract:
The present invention is directed to novel methods of treating a subject with a bone deficit disorder. The methods generally include administering to a subject in need thereof a pharmaceutically acceptable formulation comprising a parathyroid hormone (PTH) peptide analogue in a daily dose sufficient to result in an effective pharmacokinetic profile and maintained adenylate cyclase activity, while simultaneously reducing undesirable side effects.
Foot & Ankle AssociatesFoot & Ankle Associates Of Maine 81 Medical Ctr Dr STE 2100, Brunswick, ME 04011 (207)7254008 (phone), (207)7255749 (fax)
Foot & Ankle AssociatesFoot & Ankle Associates Of Maine 66 Chapman St, Damariscotta, ME 04543 (207)5633233 (phone), (207)5633201 (fax)
Procedures:
Arthrocentesis Hallux Valgus Repair
Conditions:
Hallux Valgus Plantar Fascitis Tinea Pedis
Languages:
English
Description:
Dr. Macdonald works in Damariscotta, ME and 1 other location and specializes in Podiatric Medicine. Dr. Macdonald is affiliated with Central Maine Medical Center, Lincoln Health Miles Memorial Hospital, Maine General Medical Center, Mid Coast Hospital and Saint Marys Regional Medical Center.
Name / Title
Company / Classification
Phones & Addresses
Mr. Brian MacDonald Owner
Hunt Royal Plumbing & Heating Plumbers
6 - 391 Marwood Dr, Oshawa, ON L1H 7P8 (416)7510252
Brian MacDonald President
L A Radioworks Schools-Business & Vocational
105 400 Smithe, Vancouver, BC V6B 5E4 (604)6696635,
Brian Macdonald Manager
Bennett - Macdonald Corporation Accountants
5808 190a St, Edmonton, AB T6M 2G5 (780)4875971, (780)4813570
Brian MacDonald Owner
Brian's Home Health Care Home Health Services
70 Thames Street North, Ingersoll, ON N5C 3C7 (519)4855555
Mr. Brian Macdonald Manager
Firestone BC Tire & Auto Centre Auto Repair & Service
1 English St, Brampton, ON L6X 1L3 (905)4592610
Brian Macdonald Vice President Clinical Development
Theraquest Biosciences, Inc. Drugs, Drug Proprietaries, and Druggists' Sun...
Blue Bell, PA 19422
Brian Macdonald PRESIDENT
SEWER MAN, INC TO CONDUCT DRAIN AND SEWER CLEANING SERVICES.
San Jose, CAManager of Professional Services at EK Health Serv... Manager of Professional Serivce, directing Utilization Review and Workplace Safety/Ergonomics Services departments for EKHealth, headquartered in San Jose CA. ... Manager of Professional Serivce, directing Utilization Review and Workplace Safety/Ergonomics Services departments for EKHealth, headquartered in San Jose CA. Doctor of Chiropractic, Certified Ergonomist, Qualified Medical Evaluator - CA Worker's Comp. Expert consultant in Occupational Safety and...
Morden High School Morden Palestinian Territory, Occupie 1978-1982, Midland Collegiate Miami High School Miami Palestinian Territory, Occupie 1980-1983
Nazareth, PA Syracuse, NY Philadelphia, PA Playa del Rey, CA
Work:
ConsumerTrack Inc - Web Developer (2010)
Education:
Syracuse University - Information Systems
Brian Macdonald
Work:
Family Anatomy - Host (2008)
Education:
University of Ottawa - Psychology
Tagline:
Psychologist and founder of Family Anatomy
Brian Macdonald
Work:
Department of Veteran's Affairs - Telehealth Clinical Technician
Education:
Boston University CDIA - 3D Animation, Boston University Corporate Education Center - Web Design & Development
Brian Macdonald
Lived:
Miami, FL
Work:
CareCloud - Director of Sales Training
Education:
University of Florida
Brian Macdonald
Education:
Kaplan University - MS Homeland Security and Emergency Management, Rutgers University - BS Criminal Justice, Brookdale Community College - AA Criminal Justice
Brian Macdonald
Education:
University of Washington - Computer Science
Relationship:
Married
About:
Leading the Program Management team for Bing at Microsoft.
Brian Macdonald
Education:
Saint michael's college - M.Ed., Education, University of Texas at Austin - Radio, television & film
Tagline:
Jeez - more social in person.
Brian Macdonald
Education:
Dalhousie University - MPA, Dalhousie University - B.A, French & Sociology