Brian J Mccabe

US Patent:

55042740, Apr 2, 1996

Filed:

Sep 20, 1994

Appl. No.:

8/309295

Inventors:

Brian L. McCabe - Orange CT
Edward L. Kirchner - Stratford CT

Assignee:

United Technologies Corporation - Hartford CT

International Classification:

H01B 734

US Classification:

174 36

Abstract:

A lightweight braided metallic shielding is applied to wiring harnesses to protect against lightning strikes and electromagnetic interference (EMI). The braided shielding has an open braid construction which may be as much as 40% lighter in weight and which provides better electromagnetic shielding than conventional braided shielding. The decrease in weight is achieved by utilizing a braid carrier application angle, as measured from the axis of the wire harness, which is as small as about eighteen degrees, so as to produce a braided shield that has as few as four picks per inch. The ensuing braided shield is very flexible and results in a degree of wire harness coverage which may be as low as about 60%, but which exhibits low electrical resistance which contributes significantly to lightning protection and EMI shielding.

US Patent:

20160370256, Dec 22, 2016

Filed:

Sep 2, 2016

Appl. No.:

15/255447

Inventors:

- Farmington CT, US
Brian L. McCabe - Orange CT, US
Joseph V. Mantese - Ellington CT, US
Kurt J. Sobanski - Glastonbury CT, US

International Classification:

G01M 15/14
H04B 1/02

Abstract:

A system of a machine includes a network of a plurality of sensing/control/identification devices distributed throughout the machine, each of the sensing/control/identification devices associated with at least one sub-system component of the machine and operable to communicate through a plurality of electromagnetic signals. The system also includes shielding surrounding at least one of the sensing/control/identification devices to contain the electromagnetic signals proximate to the at least one sub-system component. The system further includes an electromagnetic sensing system to read the plurality of electromagnetic signals for detection of at least one condition of the sub-system component of the machine. The system yet further includes a remote processing unit operable to communicate with the network of the sensing/control/identification devices through the electromagnetic signals.

US Patent:

20150064234, Mar 5, 2015

Filed:

Mar 26, 2013

Appl. No.:

14/388421

Inventors:

Brian D. Mccabe - New York NY, US

Assignee:

THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK - NEW YORK NY

International Classification:

A61K 31/4409
A61K 9/127

US Classification:

424450, 514352, 514357, 514605, 51425407, 514643, 514318, 514274, 514278

Abstract:

It has been discovered that pharmacological inhibition of K+ channels (using the FDA-approved broad-spectrum K+ channel antagonist 4-AP) positively benefitted smn mutant phenotypes, a result that is consistent with the defective excitability of motor circuits by their interneuron or sensory neuron inputs being a critical consequence of SMN depletion. Based on these observations, certain embodiments of the invention are directed to methods of treatment of SMA by administering therapeutically effective amounts of one or more potassium channel antagonists, including 4-aminopyridine, 4-(dimethylamino)pyridine, 4-(methylamino)pyridine, and 4-(aminomethyl)pyridine. Other embodiments are directed to new pharmaceutical formulations comprising two or more potassium channel antagonists.