Brian P O'Rourke

US Patent:

20020091144, Jul 11, 2002

Filed:

Oct 15, 2001

Appl. No.:

09/977558

Inventors:

Eduardo Marban - Lutherville MD, US
Brian O'Rourke - Sparks MD, US
Masaharu Akao - Baltimore MD, US

Assignee:

Johns Hopkins University

International Classification:

A61K031/44
A61K031/549

US Classification:

514/350000, 514/223200, 514/349000

Abstract:

New methods are provided for treating against apoptotic cell death, including apoptotic cardiac and neuronal cells. Therapies of the invention include administration of a mitochondrial oxidizer compound to a subject in need thereof, such as a subject suffering from or susceptible to stroke, heart attack, brain or spinal cord trauma, or chronic conditions that can resulting apoptotic cell death such as a neurodegenerative disease.

US Patent:

20030018745, Jan 23, 2003

Filed:

Jun 20, 2002

Appl. No.:

10/176469

Inventors:

Jim McGowan - Dix Hills NY, US
Mark Dresner - Dix Hills NY, US
Brian O'Rourke - New York NY, US

International Classification:

G06F015/16
H04N007/173
G06F017/00

US Classification:

709/217000, 707/104100, 725/125000

Abstract:

A system and method for creating and distributing virtual channels of digital video content. Initially, a first entity is enabled to acquire digital video content from one or more sources and store the digital video content into a database storage device. Next, the first entity is enabled to select digital video content and group the selected digital video content to form virtual specialty channels, each virtual specialty channel having content customized for a particular viewer base. The created virtual specialty channels are stored in the database storage device which is accessible by a second entity over a public communications network. The second entity comprises infrastructure for delivering virtual specialty channels to individual viewers over a broadband communications channel. The second entity receives a webcast of the virtual specialty channels, and the second entity distributes one or more virtual specialty channels to individual viewers over a broadband communications channel, where they are received by viewer television devices. Viewer interactivity is enhanced as interactive links may be embedded in the video content by the first and second entities with the links displayed on the television. The links are selectable by viewers, and when selected, a viewer is enabled to interact with third entities via their associated television set-top box and over the public communications network.

US Patent:

20130068313, Mar 21, 2013

Filed:

Sep 21, 2011

Appl. No.:

13/238155

Inventors:

Fred Albert George - Easton CT, US
Brian J. O'Rourke - Watertown CT, US
Lee D. Scott - New Fairfield CT, US

Assignee:

Accutrol, LLC - Monroe CT

International Classification:

F16K 31/02

US Classification:

137 14, 1374875

Abstract:

A flow valve with an integral pressure-independent fluid flow controller for controlling the flow of fluid and corresponding methods for controlling fluid flow are provided. The flow valve comprises a valve body, one or more valve blades arranged on the valve body for controlling fluid flow in a duct section, an actuator for modulating the one or more valve blades, a flow sensor or sensors for sensing fluid flow, a tuning calculation module adapted for determining or monitoring a pressure drop across the valve body and for calculating tuning constants based on the pressure drop, and a controller for controlling the actuator based on a difference between a fluid flow setpoint and the sensed fluid flow in accordance with the tuning constants. The pressure drop may be determined from an algorithm based on blade position and sensed fluid flow, or may be directly measured.

US Patent:

61839485, Feb 6, 2001

Filed:

Apr 15, 1998

Appl. No.:

9/060774

Inventors:

Eduardo Marban - Lutherville MD
Brian O'Rourke - Sparks MD

Assignee:

Johns Hopkins University - Baltimore MD

International Classification:

C12N 500

US Classification:

435 4

Abstract:

The present invention relates to methods for identifying a compound capable of modulating mitochondrial function, comprising contacting a eukaryotic cell with one or more candidate compounds, and detecting a change in the mitochondrial redox state of the cell. The methods further relates to such methods wherein endogenous fluorescence of the cell mitochondria is indicative of a change of redox state.

US Patent:

20210340541, Nov 4, 2021

Filed:

Jul 15, 2021

Appl. No.:

17/377351

Inventors:

- BRONX NY, US
Brian O'ROURKE - Rockville Centre NY, US

Assignee:

ALBERT EINSTEIN COLLEGE OF MEDICINE - BRONX NY

International Classification:

C12N 15/113
C07K 14/47

Abstract:

Methods and compositions are provided for inhibiting or treating metastasis based on discoveries regarding Kif19 and Cep192. Methods and compositions are provided for enhancing wound healing, treating fibrosis, reducing scarring and treating nerve pain.

US Patent:

20200338111, Oct 29, 2020

Filed:

Oct 16, 2018

Appl. No.:

16/758323

Inventors:

- Santa Cruz CA, US
Brian O'ROURKE - Rockville Centre NY, US

Assignee:

MICROCURES, INC. - Santa Cruz CA

International Classification:

A61K 31/7105
A61B 18/20
A61N 5/06
A61K 8/60
A61K 9/00
A61K 47/36
A61K 47/32
A61P 17/02
A61Q 19/08
C12N 15/113

Abstract:

Methods of enhancing skin health recovery from a skin procedure comprising laser application to the skin using a siRNA or shRNA directed against a human Fidgetin like-2 nucleic acid.

US Patent:

20200289394, Sep 17, 2020

Filed:

Oct 23, 2018

Appl. No.:

16/768398

Inventors:

- Santa Cruz CA, US
Brian O'ROURKE - Rockville Centre NY, US

Assignee:

MICROCURES, INC. - Santa Cruz CA

International Classification:

A61K 8/60
A61K 31/712
A61K 8/46
A61K 8/73

Abstract:

The disclosure provides methods of enhancing hair growth and hair follicle restoration using a siRNA or shRNA directed against a human Fidgetin like-2 nucleic acid. Specifically, the disclosure provides compositions comprising siRNA or shRNA against a human Fidgetin like-2 nucleic acid, and the methods of using the compositions. Further disclosed are siRNA sequences against a human Fidgetin like-2 nucleic acid and the formulations of the compositions.

US Patent:

20200277602, Sep 3, 2020

Filed:

Jan 9, 2020

Appl. No.:

16/738758

Inventors:

- Bronx NY, US
Brian O'ROURKE - Rockville Centre NY, US

Assignee:

ALBERT EINSTEIN COLLEGE OF MEDICINE - Bronx NY

International Classification:

C12N 15/113
C07K 14/47

Abstract:

Methods and compositions are provided for inhibiting or treating metastasis based on discoveries regarding Kif19 and Cep192. Methods and compositions are provided for enhancing wound healing, treating fibrosis, reducing scarring and treating nerve pain.