George Pettit - Paradise Valley AZ, US Brian Orr - Del Mar CA, US Sylvie Ducki - Salford, GB
International Classification:
A61K031/665
US Classification:
514/099000
Abstract:
A new and efficient synthesis of the (+)-pancratistatin phosphate prodrug has been accomplished. Selective protection (tetraacetate ) of (+)-pancratistatin () was followed by phosphorylation (to ) with dibenzyl chlorophosphite (prepared in situ from dibenzyl phosphite). Cleavage of the acetate (with sodium methoxide) and benzyl (by hydrogenolysis) protecting groups followed by concomitant reaction with two equivalents of sodium methoxide afforded good yield of disodium (+)-pancratistatin phosphate (). Further increases in yields of the prodrug () were realized by avoiding heat in the final purification steps. Fourteen (-) additional metal and ammonium derived phosphate prodrugs were also synthesized.
Preparation Of Sufentanil Citrate And Sufentanil Base
- Webster Groves MO, US Brian Orr - Webster Groves MO, US Joel McClenaghan - Webster Groves MO, US
International Classification:
C07D 409/06 C07C 51/41
Abstract:
Provided herein are processes for forming sufentanil citrate from sufentanil base. One process comprises forming sufentanil citrate in the presence of a polar non-aqueous solvent. Other processes comprise forming sufentanil citrate in the presence of water.
Preparation Of Sufentanil Citrate And Sufentanil Base
- Webster Groves MO, US Brian Orr - Webster Groves MO, US Joel McClenaghan - Webster Groves MO, US
International Classification:
C07D 409/06 C07C 51/41
Abstract:
Provided herein are processes for forming sufentanil citrate from sufentanil base. One process comprises forming sufentanil citrate in the presence of a polar non-aqueous solvent. Other processes comprise forming sufentanil citrate in the presence of water.
Preparation Of Sufentanil Citrate And Sufentanil Base
- Webster Groves MO, US Brian Orr - Hazelwood MO, US Joel McClenaghan - Hazelwood MO, US
International Classification:
C07D 409/06 C07C 51/41
Abstract:
Provided herein are processes for forming sufentanil citrate from sufentanil base. One process comprises forming sufentanil citrate in the presence of a polar non-aqueous solvent. Other processes comprise forming sufentanil citrate in the presence of water.
Preparation Of Sufentanil Citrate And Sufentanil Base
- Hazelwood MO, US Brian Orr - Hazelwood MO, US Joel McClenaghan - Hazelwood MO, US
International Classification:
C07D 409/06 C07C 55/22
Abstract:
Provided herein are processes for forming sufentanil citrate from sufentanil base. One process comprises forming sufentanil citrate in the presence of a polar non-aqueous solvent. Other processes comprise forming sufentanil citrate in the presence of water.
Preparation Of N-Alkylated Opiates By Reductive Amination
Christopher W. Grote - Webster Groves MO, US Brian Orr - O'Fallon MO, US Tao Jiang - St. Louis MO, US Gary L. Cantrell - Troy IL, US
International Classification:
C07D 489/00 C07D 489/08 C07D 489/02
US Classification:
546 15, 546 39, 546 44
Abstract:
The present invention is directed to the reduction of an N-imine moiety or a hemiaminal moiety of a morphinan in the presence of a ruthenium, rhodium, or iridium asymmetric catalyst and a hydrogen source.
Name / Title
Company / Classification
Phones & Addresses
Brian K. Orr President
ARCH CONSULTING , INC
360 Hampton Ct, Highland, IL 62249 Highland, IL 62249
News
Living Last Supper a perfect start to Easter weekend
Those playing the disciples in the event included Brian Orr as Nathaniel, Doug Winter as James the Less, Andy Acord as Andrew, Lanny Stocke as Peter, Scott Riley as Judas, Daniel Drury as John, Brady Wooten as James, Doug Hays as Thomas, Grant Gee as Philip, Tom Sutton as Matthew, Henry Bob Haley as
Date: Mar 29, 2013
Category: U.S.
Source: Google
Youtube
Brian Orr - Open Air Preaching .wmv
A clip of me open air preaching with The Ambassadors Academy at Hunnin...
Category:
Music
Uploaded:
03 Aug, 2010
Duration:
4m 48s
Brian Orr - Open Air Preaching - 3rd st. Prom...
On this one, the previous guy just ended the session with another pers...
Category:
Music
Uploaded:
04 Aug, 2010
Duration:
9m 54s
Max Bruch Violin Concerto No. 1 Op. 26 in G M...
Brian Orr accompanied by the Dorman High School orchestra plays Max Br...
Category:
Music
Uploaded:
16 Apr, 2010
Duration:
10m 1s
Brian Orr of Skyline High
website www.utahsportsac... Brian Orr getting the bucket and 1 agains...
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Sports
Uploaded:
06 Mar, 2010
Duration:
10s
Brian Orr, Poetry Reading, Buckham Galler
Category:
Entertainment
Uploaded:
23 Feb, 2010
Duration:
3m 37s
Brian Orr Candidates Forum at Panida Theater ...
Your thoughts on Health Care funding; especially the Indigent Fund and...