Brian Orr - Ofallon MO, US Miranda Steele - St. Louis MO, US
Assignee:
Mallinckrodt LLC - Hazelwood MO
International Classification:
C07D 489/12 C07D 489/02
US Classification:
546 39, 546 44
Abstract:
The invention provides processes for the production of opiate alkaloids. In particular, the present invention provides processes for the formation of opiate alkaloids that minimizes the formation of impurities.
Preparation Of Sufentanil Citrate And Sufentanil Base
- Webster Groves MO, US Brian Orr - Webster Groves MO, US Joel McClenaghan - Webster Groves MO, US
International Classification:
C07D 409/06 C07C 51/41
Abstract:
Provided herein are processes for forming sufentanil citrate from sufentanil base. One process comprises forming sufentanil citrate in the presence of a polar non-aqueous solvent. Other processes comprise forming sufentanil citrate in the presence of water.
Preparation Of Sufentanil Citrate And Sufentanil Base
- Webster Groves MO, US Brian Orr - Webster Groves MO, US Joel McClenaghan - Webster Groves MO, US
International Classification:
C07D 409/06 C07C 51/41
Abstract:
Provided herein are processes for forming sufentanil citrate from sufentanil base. One process comprises forming sufentanil citrate in the presence of a polar non-aqueous solvent. Other processes comprise forming sufentanil citrate in the presence of water.
Preparation Of Sufentanil Citrate And Sufentanil Base
- Webster Groves MO, US Brian Orr - Hazelwood MO, US Joel McClenaghan - Hazelwood MO, US
International Classification:
C07D 409/06 C07C 51/41
Abstract:
Provided herein are processes for forming sufentanil citrate from sufentanil base. One process comprises forming sufentanil citrate in the presence of a polar non-aqueous solvent. Other processes comprise forming sufentanil citrate in the presence of water.
Preparation Of Sufentanil Citrate And Sufentanil Base
- Hazelwood MO, US Brian Orr - Hazelwood MO, US Joel McClenaghan - Hazelwood MO, US
International Classification:
C07D 409/06 C07C 55/22
Abstract:
Provided herein are processes for forming sufentanil citrate from sufentanil base. One process comprises forming sufentanil citrate in the presence of a polar non-aqueous solvent. Other processes comprise forming sufentanil citrate in the presence of water.
Process For The Preparation Of Sufentanil Base And Related Compounds
Brian ORR - O'Fallon MO, US George H. KLEMM - Webster Groves MO, US Keith G. TOMAZI - Florissant MO, US
Assignee:
Mallinckrodt LLC - Hazelwood MO
International Classification:
C07D 409/06 C07D 211/58
US Classification:
546213, 546244
Abstract:
The present disclosure generally related to an improved process for the preparation of various piperidine derivatives. More particularly, the present disclosure related to an improved process for preparing sufentanil base (1) and related compounds, which advantageously utilizes more cost effective and/or less hazardous reagents, including a dispersion comprising between about 50% and about 70% by weight (based on the total weight of the dispersion) of an alkali metal hydride, such as sodium hydride, as well as eliminates the need for expensive and/or time consuming purification techniques.
Methods For Producing Hydrocodone, Hydromorphone Or A Derivative Thereof
Brian Orr - O'fallon MO, US William E. Dummitt - St. Louis MO, US
Assignee:
Mallinckrodt inc. - Hazelwood MO
International Classification:
C07D 489/00
US Classification:
546 45, 546 44
Abstract:
The present disclosure generally relates to methods for producing opioid derivatives. More particularly, the present disclosure relates to the preparation of hydromorphone, hydrocodone, or a derivative thereof, by means of a non-catalytic hydrogenation reaction of thebaine, oripavine or a derivative thereof, respectively, using a hydrazide reagent, followed by hydrolysis of the hydrogenated intermediate at a low temperature and for a short period of time. Additionally, the present disclosure relates to a composition comprising the desired hydromorphone, hydrocodone, or a derivative thereof, in combination with a 6-beta compound that is structurally related thereto.
Preparation Of N-Alkylated Opiates By Reductive Amination
Christopher W. Grote - Webster Groves MO, US Brian Orr - O'Fallon MO, US Tao Jiang - St. Louis MO, US Gary L. Cantrell - Troy IL, US
International Classification:
C07D 489/00 C07D 489/08 C07D 489/02
US Classification:
546 15, 546 39, 546 44
Abstract:
The present invention is directed to the reduction of an N-imine moiety or a hemiaminal moiety of a morphinan in the presence of a ruthenium, rhodium, or iridium asymmetric catalyst and a hydrogen source.
Resumes
Research And Development Scientist, Process Chemistry
Mallinckrodt Pharmaceuticals - Greater St. Louis Area since Jul 2013
Senior Principal Chemist
Covidien - Greater St. Louis Area since Feb 2012
Senior Principal Chemist
Covidien May 2005 - Mar 2012
Senior Research Associate
La Jolla Bioengineering Institute Oct 2004 - Apr 2005
Scientist
Cardinal Health Jun 2001 - Oct 2004
Scientist II
Education:
University of Strathclyde 1989 - 1992
PhD, Organic Chemistry
University of Strathclyde 1985 - 1989
BSc (Hons), Pure Chemistry with Specialization In Biological and Medicinal Chemistry
Coltness High School 1979 - 1985
Skills:
Gmp Organic Synthesis Pharmaceutical Industry R&D Formulation Drug Development Validation Sop Organic Chemistry Hplc Analytical Chemistry Fda Protein Chemistry Chemistry Biotechnology Technology Transfer Chromatography Design of Experiments Process Simulation Glp Uv/Vis Pharmaceutics Wet Chemistry Gc Ms Lc Ms Drug Discovery Drug Delivery Research and Development Mass Spectrometry V&V Lims Purification Nmr Capa Peptides Ftir Usp Tlc Standard Operating Procedure Process Safety Biopharmaceuticals 21 Cfr Part 11 Clinical Development Gas Chromatography Ir Uv Dissolution U.s. Food and Drug Administration Method Development
Interests:
Chemical Design For Six Sigma (Cdfss)
Awards:
Technical Achievement Award Winner Mallinckrodt Pharmaceuticals For a new API Process. Team Patent Award Winner Mallinckrodt Pharmaceuticals For an Issued Patent on a new API Process.
Lockheed Martin Aeronautics since Jul 2008
Development subteam lead (Prod Ops)
Lockheed Martin Aeronautics 2010 - 2011
Sr. Developer
Deloitte Consulting 2010 - 2011
Sr. Developer
REMEC 2008 - 2008
Development Lead
Raytheon Feb 2006 - Jul 2008
Development subteam lead (Manufacturing)
Education:
Illinois State University 1982 - 1984
BS, Applied Computer Science
Skills:
Integration Program Management Enterprise Resource Planning Requirements Analysis Sap Products
Woodforest National Bank since Dec 2010
Branch Manager
M&I Bank - Greater St. Louis Area Jan 2005 - Jan 2009
Account Exec
Education:
Southern Illinois University, Edwardsville 1987 - 1993
Bachelor of Science, Business Administration
Skills:
Microsoft Office Business Development Lead Generation Human Resources Sales Management Leadership Sales Sales Process Credit Sales Operations Training Customer Service Management Customer Retention Start Ups Security Program Management Loans Forecasting Coaching Market Analysis Team Building
Those playing the disciples in the event included Brian Orr as Nathaniel, Doug Winter as James the Less, Andy Acord as Andrew, Lanny Stocke as Peter, Scott Riley as Judas, Daniel Drury as John, Brady Wooten as James, Doug Hays as Thomas, Grant Gee as Philip, Tom Sutton as Matthew, Henry Bob Haley as
Date: Mar 29, 2013
Category: U.S.
Source: Google
Youtube
Brian Orr - Open Air Preaching .wmv
A clip of me open air preaching with The Ambassadors Academy at Hunnin...
Category:
Music
Uploaded:
03 Aug, 2010
Duration:
4m 48s
Brian Orr - Open Air Preaching - 3rd st. Prom...
On this one, the previous guy just ended the session with another pers...
Category:
Music
Uploaded:
04 Aug, 2010
Duration:
9m 54s
Max Bruch Violin Concerto No. 1 Op. 26 in G M...
Brian Orr accompanied by the Dorman High School orchestra plays Max Br...
Category:
Music
Uploaded:
16 Apr, 2010
Duration:
10m 1s
Brian Orr of Skyline High
website www.utahsportsac... Brian Orr getting the bucket and 1 agains...
Category:
Sports
Uploaded:
06 Mar, 2010
Duration:
10s
Brian Orr, Poetry Reading, Buckham Galler
Category:
Entertainment
Uploaded:
23 Feb, 2010
Duration:
3m 37s
Brian Orr Candidates Forum at Panida Theater ...
Your thoughts on Health Care funding; especially the Indigent Fund and...