Brian C Reed

US Patent:

20140003120, Jan 2, 2014

Filed:

Jun 28, 2012

Appl. No.:

13/535802

Inventors:

Chihhung Liao - Fremont CA, US
Phu Nguyen - Dublin CA, US
Vimal R. Patel - Rochester MN, US
George F. Paulik - Rochester MN, US
Peder J. Paulson - Rochester MN, US
Brian J. Reed - Rochester MN, US
Salvatore N. Storino - Rochester MN, US

Assignee:

INTERNATIONAL BUSINESS MACHINES CORPORATION - Armonk NY

International Classification:

G11C 17/16
G06F 17/50

US Classification:

365 96, 716100

Abstract:

An eFuse circuit may include a wordline, a first eFuse, a first logic gate, a first blowFET, and a first bitline discharge device. The first eFuse may have a first end coupled to the wordline and a second end. The first eFuse may have a first resistance when unblown and a second resistance when blown. The first logic gate may be coupled to the first end of the first eFuse. The first logic gate may be capable of driving enough current to blow the first eFuse. The first blowFET may have a source coupled to a first supply voltage, a gate coupled to a program signal, and a drain coupled to the second end of the first eFuse. The first bitline discharge device may have a gate coupled to the second end of the first eFuse, a source coupled to the first supply voltage, and a drain coupled to a first bitline.

US Patent:

20200385801, Dec 10, 2020

Filed:

Jun 8, 2020

Appl. No.:

16/895885

Inventors:

- Carlsbad CA, US
Jessica Lynn REED - Newark CA, US
Jason GIOIA - Belmont CA, US
Devin DRESSMAN - Pittsburgh PA, US
Nicholas HAPSHE - Salem MA, US
Brian REED - Woodbridge CT, US
John Andrew SHERIDAN - Marblehead MA, US

International Classification:

C12Q 1/6874
B01L 3/00
G01N 33/50
G01N 33/543
C12Q 1/6837

Abstract:

Methods, compositions, systems, apparatus, and kits are provided for depositing samples onto surfaces. The samples can include one or more particles, and the surface can include one or more reaction chambers. In some embodiments, the depositing can include the use of companion particles in combination with sample particles.

US Patent:

20200232017, Jul 23, 2020

Filed:

Jan 23, 2020

Appl. No.:

16/751138

Inventors:

- Guilford CT, US
Jeremy Lackey - Foster City CA, US
Brian Reed - Madison CT, US
Xinghua Shi - Madison CT, US
Haidong Huang - Madison CT, US
David Dodd - Guilford CT, US

International Classification:

C12Q 1/6818
C12Q 1/6869
G01N 21/64

Abstract:

Compositions useful for the detection of single molecules in a sample are provided. In some aspects, the disclosure provides a nucleotide connected to a nucleic acid comprising a FRET label comprising at least three luminescent molecules. In some embodiments, the nucleic acids described herein comprise one or more structural features that provide enhanced fluorescence intensity. In some aspects, methods of sequencing using the labeled nucleotides of the disclosure are provided.

US Patent:

20190382835, Dec 19, 2019

Filed:

Dec 31, 2018

Appl. No.:

16/237424

Inventors:

- Carlsbad CA, US
Jessica Lynn REED - Newark CA, US
Jason GIOIA - Belmont CA, US
Devin DRESSMAN - Pittsburgh PA, US
Nicholas HAPSHE - Salem MA, US
Brian REED - Woodbridge CT, US
John Andrew SHERIDAN - Marblehead MA, US

International Classification:

C12Q 1/6874
C12Q 1/6837
G01N 33/543
G01N 33/50
B01L 3/00

Abstract:

Methods, compositions, systems, apparatus, and kits are provided for depositing samples onto surfaces. The samples can include one or more particles, and the surface can include one or more reaction chambers. In some embodiments, the depositing can include the use of companion particles in combination with sample particles.

US Patent:

20190338343, Nov 7, 2019

Filed:

Jul 17, 2019

Appl. No.:

16/514814

Inventors:

- Carlsbad CA, US
Chieh-Yuan LI - Hayward CA, US
Brian REED - Woodbridge CT, US
Craig OBERGFELL - San Diego CA, US
Devin DRESSMAN - Pittsburgh PA, US
Abraham ROSENBAUM - Passaic NJ, US
Scott BENSON - Alameda CA, US
Andi BROKA - Carlsbad CA, US

International Classification:

C12Q 1/6806
C12Q 1/6844

Abstract:

In some embodiments, the disclosure relates generally to compositions, comprising a single reaction mixture containing a plurality of different populations of discrete supports, and a plurality of different populations of target nucleic acids. The single reaction mixture can contain a first population of beads; a second population of beads; a first population of target nucleic acids, where at least two different target nucleic acids in the first population of target nucleic acids can bind to a bead in the first population of beads; and a second population of target nucleic acids, where at least two different target nucleic acids in the second population of target nucleic acids can bind to a bead in the second population of beads. The single reaction mixture can be employed to monoclonally amplify the first target nucleic acids on the first beads, and monoclonally amplify the second target nucleic acids on the second beads.

US Patent:

20170275688, Sep 28, 2017

Filed:

Jan 3, 2017

Appl. No.:

15/397370

Inventors:

- Carlsbad CA, US
Jessica Lynn REED - Newark CA, US
Jason GIOIA - Belmont CA, US
Devin DRESSMAN - Pittsburgh PA, US
Nicholas HAPSHE - Salem MA, US
Brian REED - Woodbridge CT, US
John Andrew SHERIDAN - Marblehead MA, US

International Classification:

C12Q 1/68
B01L 3/00
G01N 33/50
G01N 33/543

Abstract:

Methods, compositions, systems, apparatus, and kits are provided for depositing samples onto surfaces. The samples can include one or more particles, and the surface can include one or more reaction chambers. In some embodiments, the depositing can include the use of companion particles in combination with sample particles.

US Patent:

20150361481, Dec 17, 2015

Filed:

Jun 11, 2015

Appl. No.:

14/736509

Inventors:

- Carlsbad CA, US
Chieh-Yuan LI - El Cerrito CA, US
Brian REED - Woodbridge CT, US
Craig OBERGFELL - San Diego CA, US
Devin DRESSMAN - Pittsburgh PA, US
Abraham ROSENBAUM - Waterbury CT, US
Scott BENSON - Alameda CA, US
Andi BROKA - Carlsbad CA, US

International Classification:

C12Q 1/68

Abstract:

In some embodiments, the disclosure relates generally to compositions, comprising a single reaction mixture containing a plurality of different populations of discrete supports, and a plurality of different populations of target nucleic acids. The single reaction mixture can contain a first population of beads; a second population of beads; a first population of target nucleic acids, where at least two different target nucleic acids in the first population of target nucleic acids can bind to a bead in the first population of beads; and a second population of target nucleic acids, where at least two different target nucleic acids in the second population of target nucleic acids can bind to a bead in the second population of beads. The single reaction mixture can be employed to monoclonally amplify the first target nucleic acids on the first beads, and monoclonally amplify the second target nucleic acids on the second beads.

US Patent:

20150031558, Jan 29, 2015

Filed:

Oct 15, 2014

Appl. No.:

14/515403

Inventors:

- Carlsbad CA, US
Jessica Lynn REED - Newark CA, US
Jason GIOIA - Belmont CA, US
Devin DRESSMAN - Swampscott MA, US
Nicholas HAPSHE - Salem MA, US
Brian REED - Woodbridge CT, US
John Andrew SHERIDAN - Marblehead MA, US

International Classification:

C12Q 1/68

US Classification:

506 2, 506 9, 506 30

Abstract:

Methods, compositions, systems, apparatus, and kits are provided for depositing samples onto surfaces. The samples can include one or more particles, and the surface can include one or more reaction chambers. In some embodiments, the depositing can include the use of companion particles in combination with sample particles.