Brian A Steer

US Patent:

7504120, Mar 17, 2009

Filed:

Jun 16, 2003

Appl. No.:

10/463720

Inventors:

Brian Steer - San Diego CA, US
Walter Callen - San Diego CA, US
Shaun Healey - Carlsbad CA, US
Geoff Hazlewood - San Diego CA, US
Di Wu - San Diego CA, US
David Blum - San Diego CA, US
Alireza Esteghlalian - La Jolla CA, US

Assignee:

Verenium Corporation - San Diego CA

International Classification:

C12N 9/24
C12N 11/00
C12P 19/14
C12Q 1/34
C12S 3/08
C12S 3/02
C12N 15/56

US Classification:

426 63, 435200, 435174, 435 18, 435274, 435277, 435278, 435267, 435 99, 426656, 510392, 536 232

Abstract:

The invention relates to xylanases and to polynucleotides encoding the xylanases. In addition, methods of designing new xylanases and methods of use thereof are also provided. The xylanases have increased activity and stability at increased pH and temperature.

US Patent:

7547534, Jun 16, 2009

Filed:

Jun 16, 2003

Appl. No.:

10/517939

Inventors:

Brian Steer - San Diego CA, US
Walter Callen - San Diego CA, US
Shaun Healey - Carlsbad CA, US
Geoff Hazlewood - San Diego CA, US
Di Wu - San Diego CA, US
David Blum - San Diego CA, US
Alireza Esteghlalian - La Jolla CA, US

Assignee:

Verenium Corporation - San Diego CA

International Classification:

C12N 9/24
A23L 1/105
C12S 3/04
C12S 3/08

US Classification:

435190, 426 63, 435277, 435278

Abstract:

The invention relates to xylanases and to polynucleotides encoding the xylanases. In addition, methods of designing new xylanases and methods of use thereof are also provided. The xylanases have increased activity and stability at increased pH and temperature.

US Patent:

7960148, Jun 14, 2011

Filed:

Jul 2, 2004

Appl. No.:

10/560957

Inventors:

Brian Steer - San Diego CA, US
Walter Callen - San Diego CA, US
Shaun Healey - Carlsbad CA, US
Derrick Pulliam - Durham NC, US

Assignee:

Verenium Corporation - San Diego CA
Syngenta Participations AG - Basel

International Classification:

C12P 19/18
C12P 7/06
C12N 9/42
A61K 47/00

US Classification:

435 97, 435161, 435209, 424439

Abstract:

The invention relates to polypeptides having glucanase, e. g. , endoglucanase, mannanase, xylanase activity or a combination of these activities, and polynucleotides encoding them. In one aspect, the glucanase activity is an endoglucanase activity (e. g. , endo-1,4-beta-D-glucan 4-glucano hydrolase activity) and comprises hydrolysis of 1,4-beta-D-glycosidic linkages in cellulose, cellulose derivatives (e. g. , carboxy methyl cellulose and hydroxy ethyl cellulose) lichenin, beta-1,4 bonds in mixed beta-1,3 glucans, such as cereal beta-D-glucans or xyloglucans and other plant material containing cellulosic parts. In addition, methods of designing new enzymes and methods of use thereof are also provided. In alternative aspects, the new glucanases e. g. , endoglucanases, mannanases, xylanases have increased activity and stability at increased pH and temperature.

US Patent:

20090221051, Sep 3, 2009

Filed:

May 7, 2009

Appl. No.:

12/402421

Inventors:

Brian STEER - San Diego CA, US
Walter Callen - San Diego CA, US
Shaun Healey - San Diego CA, US
Geoff Hazlewood - San Diego CA, US
Di Wu - San Diego CA, US
David Blum - San Diego CA, US
Alireza Esteghlalian - La Jolla CA, US

International Classification:

C12P 7/10
C12N 15/11
C12N 15/00
C12N 1/21
D21C 3/00

US Classification:

435165, 536 232, 4353201, 43525233, 435277

Abstract:

The invention relates to xylanases and to polynucleotides encoding the xylanases. In addition, methods of designing new xylanases and methods of use thereof are also provided. The xylanases have increased activity and stability at increased pH and temperature.

US Patent:

20100136113, Jun 3, 2010

Filed:

Sep 21, 2007

Appl. No.:

12/442207

Inventors:

Brian Steer - San Diego CA, US
Mark Dycaico - San Diego CA, US
Katie A. Kline - San Diego CA, US
Axel Trefzer - San Diego CA, US
Thomas Todaro - San Diego CA, US
Arne Solbak - San Diego CA, US
Fatima El-Farrah - San Diego CA, US
Alberto Alvarado - San Diego CA, US
Gerhard Frey - San Diego CA, US

Assignee:

VERENIUM CORPORATION - SAN DIEGO CA

International Classification:

A61K 9/00
C07H 21/00
C12N 15/63
C12N 1/21
C12N 5/00
C12N 1/15
C12N 1/19
C12N 5/04
A01K 67/027
A01H 5/10
A01H 5/00
C12N 9/16
A61K 38/46
C12N 11/16
C12N 11/14
C12N 11/08
C07K 16/00
A61P 43/00
C12P 21/00
C12P 7/02
C11C 3/00
C12N 15/00
C12N 15/82
C12N 15/74
C12S 3/00
A23K 1/165
A23K 1/18
A23J 3/14
A23L 1/305

US Classification:

424484, 536 232, 4353201, 4352523, 435325, 43525411, 4352542, 435348, 435419, 43525233, 43525231, 43525235, 43525234, 800 18, 800 14, 800 15, 800 16, 800 17, 800298, 435196, 424 946, 435174, 435176, 435180, 5303891, 5303873, 536 221, 53038826, 435 691, 435155, 435271, 435455, 435468, 435471, 435267, 426 63

Abstract:

This invention relates to phytases, polynucleotides encoding them, uses of the polynucleotides and polypeptides of the invention, as well as the production and isolation of such polynucleotides and polypeptides. In particular, the invention provides polypeptides having phytase activity under high temperature conditions, and phytases that retain activity after exposure to high temperatures. The phytases of the invention can be thermotolerant and/or thermostable at low temperatures, in addition to higher temperatures. The phytases of the invention can be used in foodstuffs to improve the feeding value of phytate rich ingredients. The phytases of the invention can be formulated as foods or feeds or supplements for either to, e.g., aid in the digestion of phytate. The foods or feeds of the invention can be in the form of pellets, liquids, powders and the like. In one aspect, phytases of the invention are stabile against thermal denaturation during pelleting; and this decreases the cost of the phytase product while maintaining in vivo efficacy and detection of activity in feed.

US Patent:

20120021490, Jan 26, 2012

Filed:

Jun 9, 2011

Appl. No.:

13/156538

Inventors:

Brian Steer - San Diego CA, US
Walter Callen - San Diego CA, US
Shaun Healey - Carlsbad CA, US
Derrick Pulliam - Durham NC, US

Assignee:

Syngenta Participations AG - Basel
Verenium Corporation - San Diego CA

International Classification:

C12N 9/42
C12N 15/63
C40B 50/00
C12N 5/10
C12N 1/19
C12N 1/15
C12N 15/56
C12N 1/21

US Classification:

435209, 536 232, 4353201, 4352523, 435325, 435348, 435419, 4352542, 43525411, 506 23

Abstract:

The invention relates to polypeptides having glucanase, e.g., endoglucanase, mannanase, xylanase activity or a combination of these activities, and polynucleotides encoding them. In one aspect, the glucanase activity is an endoglucanase activity (e.g., endo-1,4-beta-D-glucan 4-glucano hydrolase activity) and comprises hydrolysis of 1,4-beta-D-glycosidic linkages in cellulose, cellulose derivatives (e.g., carboxy methyl cellulose and hydroxy ethyl cellulose) lichenin, beta-1,4 bonds in mixed beta-1,3 glucans, such as cereal beta-D-glucans or xyloglucans and other plant material containing cellulosic parts. In addition, methods of designing new enzymes and methods of use thereof are also provided. In alternative aspects, the new glucanases e.g., endoglucanases, mannanases, xylanases have increased activity and stability at increased pH and temperature.

US Patent:

20130337507, Dec 19, 2013

Filed:

Mar 15, 2013

Appl. No.:

13/835743

Inventors:

Brian Steer - San Diego CA, US
Walter Callen - San Diego CA, US
Shaun Healey - San Diego CA, US
Geoff Hazlewood - San Diego CA, US
Di Wu - San Diego CA, US
David Blum - Brentwood TN, US
Alireza Esteghlalian - La Jolla CA, US

Assignee:

Verenium Corporation - San Diego CA
BP Corporation North America Inc. - Houston TX

International Classification:

C12N 9/24

US Classification:

435 99, 435200, 435188, 435174, 435177, 435176, 435180, 435267, 435264, 435132, 8401, 426 64, 426 7, 426 18, 426 52, 426 46, 426 44

Abstract:

The invention relates to xylanases and to polynucleotides encoding the xylanases. In addition, methods of designing new xylanases and methods of use thereof are also provided. The xylanases have increased activity and stability at increased pH and temperature.

US Patent:

20140017750, Jan 16, 2014

Filed:

Sep 20, 2013

Appl. No.:

14/032578

Inventors:

Brian STEER - SAN DIEGO CA, US
Mark DYCAICO - SAN DIEGO CA, US
Katie A. KLINE - SAN DIEGO CA, US
Axel TREFZER - SAN DIEGO CA, US
Thomas TODARO - SAN DIEGO CA, US
Fatima EL-FARRAH - SAN DIEGO CA, US
Alberto ALVARADO - SAN DIEGO CA, US
Gerhard FREY - SAN DIEGO CA, US

Assignee:

VERENIUM CORPORATION - SAN DIEGO CA

International Classification:

C12P 7/10

US Classification:

435165

Abstract:

A method for using a thermostable phytase for eliminating or reducing phytic acid or salts of phytic acid in an alcohol production process is disclosed. The phytase can be added anywhere in the alcohol production process including a feedstock, a hammer mill, a slurry tank, a jet cooker, a liquefaction, a mash cooker, a fermentation, a beer, a distillation system, a whole stillage, a centrifuge, a thin stillage, an evaporator, a condensate, a syrup, a wet grain, a drum dryer, a distillers dried grain, distillers solubles, distillers wet grain, condensed distillers solubles distillers dried grains with solubles a molecular sieves, or any combination thereof. The alcohol production process can be in an ethanol production plant; a spirit or a drinkable alcohol production plant; or a fuel ethanol plant.